| 1 | Adenovirus-mediated gene delivery:Potential applications for gene and cell-based therapies in the new era of personalized medicine显示文摘With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology,it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted therapies.Despite numerous setbacks,efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human diseases.It is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene therapies.There has been a long-lasting interest in using viral vectors,especially adenoviral vectors,to deliver therapeutic genes for the past two decades.Among all currently available viral vectors,adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types.The applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial development.In fact,among over 2000 gene therapy clinical trials approved worldwide since 1989,a significant portion of the trials have utilized adenoviral vectors.This review aims to provide a comprehensive overview on the characteristics of adenoviral vectors,including adenoviral biology,approaches to engineering adenoviral vectors,and their applications in clinical and preclinical studies with an emphasis in the areas of cancer treatment,vaccination and regenerative medicine.Current challenges and future directions regarding the use of adenoviral vectors are also discussed.It is expected that the continued improvements in adenoviral vectors should provide great opportunities for cell and gene therapies to live up to its enormous potential in personalized medicine. | Cody S.Lee Elliot S.Bishop Ruyi Zhang Xinyi Yu Evan M.Farina Shujuan Yan Chen Zhao Zongyue Zeng Yi Shu Xingye Wu Jiayan Lei Yasha Li Wenwen Zhang Chao Yang Ke Wu Ying Wu Sherwin Ho Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Russell R.Reid Tong-Chuan He | 2017 | Genes & Diseases2017，4，2： | 19 |
| 2 | Bronchoscopic management of persistent air leaks显示文摘Air leaks can occur as a complication of thoracic surgery,bronchoscopic procedures,or from barotrauma due to mechanical ventilation.Persistent air leaks defined as air leaks that last longer than 5–7 days are often associated with prolonged hospital stay,higher rates of intensive care unit admission,and a significant source of morbidity and mortality.Surgical repair of persistent air leaks via thoracotomy or videoassisted thorascopic surgery generally has excellent success.However,for patients with severe hypoxemia,poor functional status,or significant comorbidities,surgical repair may not be feasible.The use of bronchoscopic interventions such as the delivery of coils,covered airway stents,endobronchial valves,biological sealants,and other devices to safely and effectively manage persistent air leaks has been widely reported in recent years.Bronchoscopic intervention of persistent air leak has a reported success rate of closure ranging from 30–80%depending on the underlying disease,location,and size of the pleural fistula.It is an excellent option for patients with persistent air leak who are critically ill and are poor surgical candidates.Advantages of using endobronchial devices include quick recovery time,relatively low risk,reduction in hospital stay,and the potential for immediate symptom relief.Here,we review the data regarding the use of bronchoscopic techniques in the management of persistent air leak. | Elliot Ho Joslyn Vo Ajay Wagh Douglas Kyle Hogarth | 2021 | 中华胸部外科电子杂志2021，8，2： | 0 |
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