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| 1 | Liver transplantation in patients with incidental hepatocellular carcinoma/cholangiocarcinoma and intrahepatic cholangiocarcinoma: a single-center experience显示文摘BACKGROUND: Reports of liver transplantation(LT) in patients with mixed hepatocellular carcinoma/cholangiocarcinoma(HCC/CC) and intrahepatic cholangiocarcinoma(ICC) are modest and have been mostly retrospective after pathological categorization in the setting of presumed HCC. Some studies suggest that patients undergoing LT with small and unifocal ICC or mixed HCC/CC can achieve about 40%-60% 5-year post-transplant survival. The study aimed to report our experience in patients undergoing LT with explant pathology revealing HCC/CC and ICC.METHODS: From a prospectively maintained database, we performed cohort analysis. We identified 13 patients who underwent LT with explant pathology revealing HCC/CC or ICC. RESULTS: The observed recurrence rate post-LT was 31%(4/13) and overall survival was 85%, 51%, and 51% at 1, 3 and 5 years, respectively. Disease-free survival was 68%, 51%, and 41% at 1, 3 and 5 years, respectively. In our cohort, four patients would have qualified for exception points based on updated HCC Organ Procurement and Transplantation Network imaging guidelines. CONCLUSIONS: Lesions which lack complete imaging characteristics of HCC may warrant pre-LT biopsy to fully elucidate their pathology. Identified patients with early HCC/CC or ICC may benefit from LT if unresectable. Additionally, incorporating adjunctive perioperative therapies such as in the case of patients undergoing LT with hilar cholangiocarcinoma may improve outcomes but this warrants further investigation. | Mohammed Elshamy Naftali Presser Abdulrahman Y Hammad Daniel J Firl Christopher Coppa John Fung Federico N Aucejo | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，3： | 6 |
| 2 | Protection of auditory neurons from aminoglycoside toxicity by neurotrophin-3 显示文摘 | Emfors P Duan M L Elshamy W M | 1996 | Nat Med1996，2，： | 1 |
| 3 | Hepatocellular carcinoma beyond Milan criteria: Management and transplant selection criteria显示文摘Liver transplantation(LT) for hepatocellular carcinoma(HCC) has been established as a standard treatment in selected patients for the last two and a half decades. After initially dismal outcomes, the Milan criteria(MC)(single HCC ≤ 5 cm or up to 3 HCCs ≤ 3 cm) have been adopted worldwide to select HCC patients for LT, however cumulative experience has shown that MC can be too strict. This has led to the development of numerous expanded criteria worldwide. Morphometric expansions on MC as well as various criteria which incorporate biomarkers as surrogates of tumor biology have been described. HCC that presents beyond MC initially can be downstaged with locoregional therapy(LRT). Post-LRT monitoring aims to identify candidates with favorable tumor behavior. Similarly, tumor marker levels as response to LRT has been utilized as surrogate of tumor biology. Molecular signatures of HCC have also been correlated to outcomes; these have yet to be incorporated into HCC-LT selection criteria formally. The ongoing discrepancy between organ demand and supply makes patient selection the most challenging element of organ allocation. Further validation of extended HCCLT criteria models and pre-LT treatment strategies are required. | Mohammed Elshamy Federico Aucejo KV Narayanan Menon Bijan Eghtesad | 2016 | World Journal of Hepatology2016，8，21： | 1 |
| 4 | Protection of auditory neurons from aminoglycoside toxicity by neurotrophin- 3显示文摘 | Emfors P Duan ML ElShamy WM | 1996 | Nat Med1996，2，4： | 1 |
| 5 | Uterine septum dissection using mini-hysteroscopy with a bipotrode 5 Fr bipolar electrode versus monopolar resectoscopy with a unipolar knife: a randomized- controlled study 显示文摘 | Youssef HM Elshamy M Shokeir T | 2014 | Evidence Based Women''s Health Journal2014，4，3： | 1 |
| 6 | Differential regulation of mRNAs for GDNF and its receptors Ret and GDNFRalpha after sciatic nerve lesion in the mouse显示文摘 | Naveilhan P Elshamy WM Emfors P | 1997 | Eur J Neurosci1997，9，： | 1 |
| 7 | Gene therapy using adenovirus carrying the herpes simplex-thymi-dine kinase gene to treat in vivo models for human malignant mesothelioma and lung cancer显示文摘 | Hwang HC Smythe WR Elshami AA | 1995 | AmJ Respir Cell Bioi1995，13，： | 1 |
| 8 | Gene therapy using adenovirus carrying the herpes simplex-thymidine kinase gene to treat in vivo models of human malignant mesothelioma and lung cancer 显示文摘 | Hwang HC Smythe WR Elshami AA | 1995 | Am J Respir Cell Mol Biol1995，13，1： | 1 |
| 9 | Network modeling links breast cancer susceptibility and centrosome dysfunction显示文摘 | Pujana MA Han JD Starita LM Stevens KN Tewari M Ahn JS Rennert G Moreno V Kirchhoff T Gold B Assmann V Elshamy WM Rual JF Levine D Rozek LS Gelman RS Gunsalus KC Greenberg RA Sobhian B Bertin N Venkatesan K Ayivi-Guedehoussou N So1é X Hernández P Lázaro C | | 0，，11： | 1 |
| 10 | Plastic bronchitis 显示文摘 | Park JV Elshami AA Kang DS | 1996 | EurRespirJ1996，9，3： | 1 |
| 11 | Requirement of neurotrophin3 for the survival of proliferating trigeminal ganglion progenitor cells 显示文摘 | elshamy WM Emfors P | 1996 | Development1996，122，8： | 1 |
| 12 | Protection of auditory neurons from aminoglycoside toxicity by neurotrophin-3显示文摘 | Ernfors P Duan ML Elshamy WM | 1996 | Nat Med1996，2，： | 1 |
| 13 | Gap junctions play a role in the ' bystander effect' of the herpes simplex virus thymidine kinase/ganciclovir system in vitro显示文摘 | ELSHAMI A A SAAVEDRA A ZHANG H | 1996 | GeneTher1996，3，1： | 1 |
| 14 | CD4 T lymphocyte Count and the radiographic presentation of pulmonary tubereulo sis:a study of the relationship between the sefactors in patients with human immunodeficieney virus infection显示文摘 | Beumont M Elshami A | 1995 | Chest1995，107，1： | 1 |
| 15 | Retinoids augment the bystander effect in vitro and in vivo in herpes simplex virus thymicline kinase/ganciclovir-mediated gene therapy显示文摘 | Park JY Elshami AA Amin K | 1997 | Gene Therapy1997，4，9： | 1 |
| 16 | Gap junctions play a role in the 'bystander effect' of the herps simplex virus thymidine kinas ganciclovir system in vivo显示文摘 | Elshami AA Saavedra A Zhang H | 1996 | Gene Ther1996，3，1： | 1 |
| 17 | Differential sensitivity of thoracic maignant tumors to adenovirus-mediated drug sensitization gene therapy 显示文摘 | Hwang HC Elshami AA | 1995 | J Thorac Cardiovasc Surg1995，109，4： | 1 |
| 18 | Retinoids augment the bystander effect in vitro and in vivo in herpes simplex virus thymidine kinase/ganciclovir-mediated gene therapy显示文摘 | Park JY Elshami AA Amin K | 1997 | Gene Ther1997，4，： | 1 |
| 19 | Retinoids augme-nt the bystander effect in vitroand in vivo in herpes si-mplex virus thymidine kinase/ganciclovir-mediated genetherapy显示文摘 | Park JY Elshami AA Amin K | 1997 | Gene Therapy1997，4909，： | 1 |
| 20 | Retinoids augment the bystander effect in vitro and in vivo in herpes simples virus thymidine kinase/ ganciclovir-mediated gene therapy显示文摘 | Park JY Elshami AA Amin K | 1997 | Gene Ther1997，4，9： | 1 |
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