|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Co-encapsulation of curcumin and doxorubicin in albumin nanoparticles blocks the adaptive treatment tolerance of cancer cells显示文摘The adaptive treatment tolerance (ATT) of cancer cells is the main encumbrance to cancer chemotherapy. A potential solution to this problem is to treat cancer cells with multiple drugs using nanoparticles (NPs). In this study, we tested the co-administration of curcumin (Cur) and doxorubicin (Dox) to MCF-7 resistant breast cancer cells to block the ATTand elicit efficient cell killing. Drugs were co-administered to cells both sequentially and simultaneously. Sequential drug co-administration was carried out by pre-treating the cells with albumin nanoparticles (ANPs) loaded w让h Cur (Cur@ANPs) followed by treatment with Dox-loaded ANPs (Dox@ANPs). Simultaneous drug co-administration was carried out by treating the cells with ANPs loaded with both the drugs (Cur/Dox@ANPs). We found that the simultaneous drug co-administration led to a greater intra-cellular accumulation of Dox and cell killing with respect to the sequential drug co-administration. However;the simultaneous drug co-administration led to a lower intracellular accumulation of Cur with respect to the sequential drug co-administration. We showed that this result was due to the aggregation and entrapment of Cur in the lysosomes as soon as it was released from Cur@ANPs, a phenomenon called lysosomotropism. In contrast, the simultaneous release of Dox and Cur from Cur/Dox@ANPs into the lysosomes led to lysosomal pH elevation, which, in turn, avoided Cur aggregation, led to lysosome swelling and drug release in the cytosol, and finally provoked efficient cell killing. Our study shed the light on the molecular processes driving the therapeutic effects of anti-cancer drugs co-administered to cancer cells in different manners. | Seyed Mohammad Motevalli Ahmed Shaker Eltahan Lu Liu Andrea Magrini Nicola Rosato Weisheng Guo Massimo Bottini Xing-Jie Liang | 2019 | Biophysics Reports2019，5，1： | 3 |
| 2 | Serum Inter-Alpha-Trypsin Inhibitor Heavy Chain 4 (ITIH4) in Children with Chronic Hepatitis C: Relation to Liver Fibrosis and Viremia显示文摘 | Mostafa M. Sira Behairy E. Behairy Azza M. Abd-Elaziz Sameh A. Abd Elnaby Ehab E. Eltahan Piero Luigi Almasio | 2014 | Hepatitis Research and Treatment2014，，： | 2 |
| 3 | Use of a geo- graphic information system in site-specific groundwater modeling显示文摘 | EL-Kadi A I Oloufa A A Eltahan A A | 1994 | Groundwater1994，32，： | 1 |
| 4 | A randomised controlled trial of coblation,diode laser and cold dissection inpaediatric tonsillectomy显示文摘 | ELBADAWEY M R HEGAZY H M ELTAHAN A E | 2015 | J Laryngol Otol2015，129，： | 1 |
| 5 | Use of a Geographic Information System in Site Specific Ground-water Modeling显示文摘 | EL-Kadi A L Oloufa A A Eltahan A A | 1994 | Groundwater1994，32，4： | 1 |
| 6 | Use of a Geographic Information System in Site-Specific Groundwater Modeling显示文摘 | EL-Kadi Oloufa Eltahan Malik | 1994 | Groundwater1994，32，4： | 1 |
| 7 | Use of a geographic information system in site-specific groundwater modeling显示文摘 | EL-Kadi A I Oloufa A A Eltahan A A | 1994 | Groundwater1994，32，4： | 1 |
| 8 | Use of Geographic Information System in Site-specific Groundwater Modeling显示文摘 | Kadi E L Oloufa Eltahan | 1994 | Groundwater1994，32，4： | 1 |
| 9 | Use of a Geographic Information System in Site-Specific Groundwater Modeling显示文摘 | EL-Kadi A I Oloufa A A Eltahan A A Malik H U | 1994 | Groundwater1994，32，4： | 1 |
| 10 | Use of a geographic informaton system in site-specific groundwater modeling显示文摘 | EL-Kadi Oloufa Eltahan and Malik | 1994 | Groundwater1994，32，4： | 1 |
| 11 | Use Of a geographic information system in site - specific ground watermodeling显示文摘 | EL- Kadi Oloufa Eltahan and Malik | 1994 | Groundwater1994，32，4： | 1 |
| 12 | NVP-BEZ235/Chlorin-e6 co-loaded nanoparticles ablate breast cancer by biochemical and photodynamic synergistic effects显示文摘为三元组否定的乳癌(TNBC ) 寻求有利治疗吸引了强烈研究兴趣。然而,为 TNBC 的有效痊愈在肿瘤学仍然是未解决的挑战。第一次,此处,我们描述与 NVP-BEZ235 和 Chlorin-e6 装载的聚合 nanoparticles 的使用,作为 NVP/Ce6@NPs 表示了,在生物化学、光力学的治疗之间完成由利用 synergistic 克服 TNBC 的适应治疗忍耐。在激光照耀之上, NVP/Ce6@NPs 产生了反应的氧种类(ROS ) 并且高效地通过 DNA 损坏导致了肿瘤房间的 apoptosis。而且,释放 NVP-BEZ235 能阻止 Chk1 导致 phosphorylation 的 DNA 损坏修理,因此提高肿瘤房间的敏感到 ROS。忍受一个 MDA- MB-231 肿瘤的老鼠上的动物研究验证了 NVP/Ce6@NPs 与 monotherapies 的相比有更大的治疗学的功效,与 89.3% 的抑制比率。西方的弄污和房间生存能力分析由 NVP/Ce6@NPs 证实了两 MDA-MB-231 房间增长和 Chk1 phosphorylation 的抑制。这些调查结果提供生物化学 / 光力学的治疗的 synergistic 效果的合理理解并且铺平道路让有效治疗学的途径的发展与 TNBC 斗争。 | Ahmed Shaker Eltahan Lu Liu Chukwunweike Ikechukwu Okeke Min Huang Lu Han Jing Chen Xue Xue Massimo Bottini Weisheng Guo Xing-Jie Liang | 2018 | Nano Research2018，11，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员