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1患者肠道微生物群失调与肠上皮屏障功能障碍显示文摘最近的证据表明,在动物模型中,肠道病理学和微生物组与高血压之间存在联系。然而,这种关联在人类中是否存在尚不清楚。因此,该研究的目的是检验高血压患者具有明显特异的肠道微生物组以及肠上皮屏障功能标记物和微生物组组成可以预测收缩压变化的假设。研究者通过鸟枪法宏基因组学分析粪便样本显示微生物分类和功能变化,结果显示高血压患者和对照受试者之间丁酸盐产生存在差异。Kim S Goel R Kumar A Qi Y Lobaton G Hosaka K Mohammed M Handberg EM Richards EM Pepine CJ Raizada MK 刘青 叶鹏 2018中华高血压杂志2018,26,9:45
2美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) 2012中华神经科杂志2012,45,5:22
3The role of voxel aspect ratio in determining apparent vascular phase behavior in susceptibility weighted imaging显示文摘Xu Y Haacke EM 2006Magn Reson lmaging2006,24,2:1
4The use of short-course zidovudine to prevent perinatal transmission of human immunodeficiency virus in rural Kenya显示文摘Songok EM Fujiyama Y Tukei PM 2003Am J Trop Med Hyg2003,69,1:1
5Susceptibaility weigh- ted imaging (SWI) 显示文摘Haacke EM Xu Y Cheng YC 2004Magn Reson Mecl2004,52,:1
6A technique for atraumatic extrac- tion of teeth before immediate implant placement 显示文摘Yalcin S Aktas I Emes Y 2009Implant Dent2009,18,6:1
7susceptibility weighted ima-ging(SWl) 显示文摘Haacke EM Xu Y Chen YC ei al 2004Magnetic Resonan cein Medicine2004,52,3:1
8Correlation of putative iron content as represented by changes R2 * and phase with age in deep gray matter of healthy adults显示文摘Haacke EM Miao Y Liu M 2010J Magn Reson Imaging2010,32,:1
9Early c-Fos induction after cerebral ischemia:A possible neuroprotective role显示文摘Cho S Park EM Kim Y 2001J CerebBlood Flow Metab2001,21,5:1
10Language hemispheric dominance in patients with congenital lesions of eloquent brain显示文摘VIKINGSTAD EM CAO Y THOMAS AJ 2000Neurosurgery2000,47,:1
11Cost analysis of singleton versus twin pregnancies after in vitro fertilization显示文摘Lukassen HG Sch6nbeck Y Adang EM 2004Fertil Steril2004,81,5:1
12Susceptibility weighted imaging(SWI)显示文摘Haacke EM Xu Y Cheng YC 2004Magn Reson Med2004,52,3:1
13Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6显示文摘Martinez de la Torte Y Buracchi C Borroni EM 2007Proc Natl Acad Sci USA2007,104,7:1
14Anticoagulation therapy for stroke prevention in atrial fibrillation: how well do randomized trial translate into clinical practice?显示文摘GO AS HYLEK EM CHANG Y 2003JAMA2003,290,20:1
15PTEN mutations in gliomas and glioneuronal tumors 显示文摘Duerr EM Rollbrocker B Hayashi Y 1998Oncogene1998,16,17:1
16A pilot study of subjects recovered from hemiparetic stroke 显示文摘Cao Y D'Olhaberriague L Vikingstad EM 1997Stroke1997,28,:1
17Immunophenotypic analysis of the Kaposi sarcoma herpesvirus (KSHV, HHV-8)-infected B cells in HIV + multicentric Castleman disease (MCD) 显示文摘Chadburn A Hyjek EM Tam W Liu Y 2008Histopathology2008,53,5:1
18Overweight and obese in gestational diabetes:The impact on pregnancy outcome显示文摘Langer O Yogev Y Xenakis EM 2005Am J Obstet Gynecol2005,192,6:1
19Cortical language activation in stroke patients recovering from aphasia with functional MRI显示文摘 Vikingstad EM George KP 1999Stroke1999,30,:1
20The association between preeclampsia and the severity of gestational diabetes: the impact of glycemic control 显示文摘Yogev Y Xenakis EM Langer O 2004Am J Obstet Gynecol2004,191,5:1
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