2篇
您的检索式：作者名="Emmanuel Boateng"
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| 1 | Forensic Identification of Missing Persons using DNA from Surviving Relatives and Femur Bone Retrieved from Salty Environment显示文摘Human identification using forensic DNA profiling has made enormous advancement over the past two‑and‑half decades.Forensic DNA profiling provides enormous genetic data from a variety of biological materials and individualsto help solve many important criminal and civil cases that confront society.Under certain environmental conditions,the total deterioration of soft-tissue leaves skeletal remains as the only available sample for DNA testing to identify missing persons,victims of natural disasters,or exonerate suspect(s)in a criminal case.We report the findings of a case involving the human remains of a missing person submitted to the Forensic Science Laboratory of the Ghana Police Service for forensic DNA profiling in comparison to an alleged living relative of the deceased.DNA from the femur bone and buccal swabs of alleged relative of the deceased were extracted,quantified,and short tandem repeat(STR)profiled using Qiagen’s Investigator kit,Applied Biosystem’s Quantifiler trio,and GlobalFiler kits.Full STR profiles were generated for both the femur bone from the salty environment and the buccal swabs from the alleged relative.The femur bone was genetically identified to be that of the missing person.The remains were thus handed over to the relatives for final funeral rites and burial to bring closure to the long search for the missing person. | Kofi Adjapong Afrifah Alexander Badu‑Boateng Samuel Antwi‑Akomeah Eva Emefa Motey Emmanuel Boampong Peter Twumasi Paul Poku Sampene Augustine Donkor | 2020 | Journal of Forensic Science and Medicine2020，6，1： | 0 |
| 2 | Dissecting novel mechanisms of hepatitis B virus related hepatocellular carcinoma using meta-analysis of public data显示文摘BACKGROUND Hepatitis B virus(HBV) is a cause of hepatocellular carcinoma(HCC). Interestingly, this process is not necessarily mediated through cirrhosis and may in fact involve oncogenic processes. Prior studies have suggested specific oncogenic gene expression pathways were affected by viral regulatory proteins. Thus, identifying these genes and associated pathways could highlight predictive factors for HCC transformation and has implications in early diagnosis and treatment.AIM To elucidate HBV oncogenesis in HCC and identify potential therapeutic targets.METHODS We employed our Search, Tag, Analyze, Resource platform to conduct a meta-analysis of public data from National Center for Biotechnology Information’s Gene Expression Omnibus. We performed meta-analysis consisting of 155 tumor samples compared against 185 adjacent nontumor samples and analyzed results with ingenuity pathway analysis.RESULTS Our analysis revealed liver X receptors/retinoid X receptor(RXR) activation and farnesoid X receptor/RXR activation as top canonical pathways amongst others. Top upstream regulators identified included the Ras family gene rab-like protein 6(RABL6). The role of RABL6 in oncogenesis is beginning to unfold but its specific role in HBV-related HCC remains undefined. Our causal analysis suggests RABL6 mediates pathogenesis of HBV-related HCC through promotion of genes related to cell division, epigenetic regulation, and Akt signaling. We conducted survival analysis that demonstrated increased mortality with higher RABL6 expression. Additionally, homeobox A10(HOXA10) was a top upstream regulator and was strongly upregulated in our analysis. HOXA10 has recently been demonstrated to contribute to HCC pathogenesis in vitro. Our causal analysis suggests an in vivo role through downregulation of tumor suppressors and other mechanisms.CONCLUSION This meta-analysis describes possible roles of RABL6 and HOXA10 in the pathogenesis of HBV-related HCC. RABL6 and HOXA10 represent potential therapeutic targets and warrant further investigation. | Jihad Aljabban Michael Rohr Saad Syed Eli Cohen Naima Hashi Sharjeel Syed Kamal Khorfan Hisham Aljabban Vincent Borkowski Michael Segal Mohamed Mukhtar Mohammed Mohammed Emmanuel Boateng Mary Nemer Maryam Panahiazar Dexter Hadley Sajid Jalil Khalid Mumtaz | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 0 |
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