4篇
您的检索式：作者名="Emmanuel TE"
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| 1 | Evolution of laparoscopy in colorectal surgery:An evidencebased review显示文摘Open surgery for colorectal disease has progressed significantly over the past century from humble beginnings to form the mainstay of treatment for colorectal cancer and a number of benign conditions.Following the introduction of laparoscopic abdominal surgery,the next stage in the evolution of the specialty began in the 1990s with the first laparoscopic colonic resection.Following some early concerns regarding its safety and oncological efficacy during the latter part of that decade,laparoscopic colorectal surgery rapidly came into mainstream use in the early part of the current century with evidence supporting its use being made available from large scale randomised controlled trials.This article provides an evidence-based summary of this evolutionary process as it relates to both benign and malignant colorectal disease,as well as discussion of the next phase of new technologies such as robotic surgery. | Alexander Emmanuel Blackmore Mark Te Ching Wong Choong Leong Tang | 2014 | World Journal of Gastroenterology2014，20，17： | 12 |
| 2 | Comparison of the operation time and complications between conventional and robotic-assisted Laparoscopic pyeloplasty显示文摘 | Gare GE Emmanuel TE Navarro VP | 2011 | Actas Urol Esp2011，35，9： | 1 |
| 3 | Early verbal fluency decline after STN implantation: Is it a cognitive microlesion effect?显示文摘 | Romain Lefaucheur Stéphane Derrey Olivier Martinaud David Wallon Nathalie Chastan Emmanuel Gérardin Didier Hannequin David Maltête | 2012 | Journal of the Neurological Sciences (-)2012，，1： | 1 |
| 4 | Exploring the utility of organo-polyoxometalate hybrids to inhibit SOX transcription factors显示文摘Background:SOX transcription factors constitute an attractive target class for intervention with small molecules as they play a prominent role in the field of regenerative biomedicine and cancer biology.However,rationally engineering specific inhibitors that interfere with transcription factor DNA interfaces continues to be a monumental challenge in the field of transcription factor chemical biology.Polyoxometalates(POMs)are inorganic compounds that were previously shown to target the high-mobility group(HMG)of SOX proteins at nanomolar concentrations.In continuation of this work,we carried out an assessment of the selectivity of a panel of newly synthesized organo-polyoxometalate hybrids in targeting different transcription factor families to enable the usage of polyoxometalates as specific SOX transcription factor drugs.Results:The residual DNA-binding activities of 15 different transcription factors were measured after treatment with a panel of diverse polyoxometalates.Polyoxometalates belonging to the Dawson structural class were found to be more potent inhibitors than the Keggin class.Further,organically modified Dawson polyoxometalates were found to be the most potent in inhibiting transcription factor DNA binding activity.The size of the polyoxometalates and its derivitization were found to be the key determinants of their potency.Conclusion:Polyoxometalates are highly potent,nanomolar range inhibitors of the DNA binding activity of the Sox-HMG family.However,binding assays involving a limited subset of structurally diverse polyoxometalates revealed a low selectivity profile against different transcription factor families.Further progress in achieving selectivity and deciphering structure-activity relationship of POMs require the identification of POM binding sites on transcription factors using elaborate approaches like X-ray crystallography and multidimensional NMR.In summary,our report reaffirms that transcription factors are challenging molecular architectures and that future polyoxometalate chemistry must consider further modification strategies,to address the substantial challenges involved in achieving target selectivity. | Kamesh Narasimhan Kevin Micoine Emmanuel Lacôte Serge Thorimbert Edwin Cheung Bernold Hasenknopf Ralf Jauch | 2014 | Cell Regeneration2014，3，1： | 0 |
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