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| 1 | Application of liquid chromatography with mass spectrometry combined with photodiode array detection and tandem mass spectrometry for monitoring pesticides in surface waters显示文摘 | Roger Jeannot Hassan Sabik Emmanuel Sauvard | 2000 | Journal of chromatography A2000，879，1： | 1 |
| 2 | Clinical, Morphologic, and Molecular Features Defining So-Called Telangiectatic Focal Nodular Hyperplasias of the Liver显示文摘 | Paulette Bioulac-Sage Sandra Rebouissou Antonio Sa Cunha Emmanuelle Jeannot Sébastien Lepreux Jean-Frédéric Blanc Hélène Blanché Brigitte le Bail Jean Saric Pierre Laurent-Puig Charles Balabaud Jessica Zucman-Rossi | 2005 | Gastroenterology2005，，5： | 1 |
| 3 | Biomarkers of cetuximab resistance in patients with head and neck squamous cell carcinoma显示文摘Objective:In patients with head and neck squamous cell carcinoma(HNSCC),cetuximab[a monoclonal antibody targeting epidermal growth factor receptor(EGFR)]has been shown to improve overall survival when combined with radiotherapy in the locally advanced setting or with chemotherapy in first-line recurrent and/or metastatic(R/M)setting,respectively.While biomarkers of resistance to cetuximab have been identified in metastatic colorectal cancer,no biomarkers of efficacy have been identified in HNSCC.Here,we aimed to identify biomarkers of cetuximab sensitivity/resistance in HNSCC.Methods:HNSCC patients treated with cetuximab at the Curie Institute,for whom complete clinicopathological data and formalin-fixed paraffin-embedded(FFPE)tumor tissue collected before cetuximab treatment were available,were included.Immunohistochemistry analyses of PTEN and EGFR were performed to assess protein expression levels.PIK3 CA and H/N/KRAS mutations were analyzed using high-resolution melting(HRM)and Sanger sequencing.We evaluated the predictive value of these alterations in terms of progression-free survival(PFS).Results:Hot spot activating PIK3 CA and KRAS/HRAS mutations were associated with poor PFS among HNSCC patients treated with cetuximab in the first-line R/M setting,but not among HNSCC patients treated with cetuximab in combination with radiotherapy.Loss of PTEN protein expression had a negative predictive value among HNSCC patients treated with cetuximab and radiotherapy.High EGFR expression did not predict cetuximab sensitivity in our patient population.Conclusions:Hot spot activating PIK3 CA and RAS mutations predicted cetuximab resistance among HNSCC patients in the firstline R/M setting,whereas loss of PTEN protein expression predicted resistance to cetuximab when combined to radiotherapy. | Olivia Leblanc Sophie Vacher Charlotte Lecerf Emmanuelle Jeannot Jerzy Klijanienko Frederique Berger Caroline Hoffmann Valentin Calugaru Nathalie Badois Anne Chilles Maria Lesnik Samar Krhili IvanBieche Christophe Le Tourneau Maud Kamal | 2020 | Cancer Biology & Medicine2020，17，1： | 0 |
| 4 | 复杂环境中的高性能计算显示文摘高性能计算(HPC,High.Performance Computing)使用超级计算机和计算机集群来解决高等计算问题。今天,接近万亿次浮点运算区域的电脑系统都可算作高性能计算机。在超过30年中,它解决了许多问题,加强了许多科学和工业领域的进展如气候、生物、地质、药物设计、汽车、航空航天。然而,新的技术,如多核处理器和加速器(GPGPU),迫使研究人员重新思考该领域的进步。 | Emmanuel Jeannot 李亚宁 | 2015 | 国外科技新书评介2015，0，4： | 0 |
| 5 | 红色激情 法国La Hague文化中心显示文摘La Hague文化中心位于法国科唐坦半岛的博蒙阿盖海牙。这是一片拥有优质景观资源的区域,而文化中心的建成不但使建筑与环境相互融合,更起到相得益彰的作用。在半岛的岸边,下沉的道路两旁种植着繁茂的树木,在形成巨大防风带的同时,也抵挡着夏日阳光的猛烈照射。透过树叶的间隙,日光柔和地洒落在地面上,形成斑驳闪烁的光影。这些景观元素不仅构成了当地特殊的地域文化,同时也成为启发设计师灵感的源泉。 | 小麦(编译) Charlotte Letebvre Anne Clerget Emily Murphy Alfredo Luvison Camille Isaac-DogninGabriele Motta Anatole Jeannot Kirsten Elliot Thomas Dantec Yann Peter Alexandre Pascal Mehrnoush Naraghi Estelle Grange-Dubelle Sergio GRAZIA(摄影) 无 | 2016 | 室内设计与装修2016，0，9： | 0 |
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