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| 1 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 2 | Recombinant amelogenin regulates the bioactivity of mouse cementoblasts in vitro显示文摘Amelogenin(AMG) is a cell adhesion molecule that has an important role in the mineralization of enamel and regulates events during dental development and root formation. The purpose of the present study was to investigate the effects of recombinant human AMG(rhAMG) on mineralized tissue-associated genes in cementoblasts. Immortalized mouse cementoblasts(OCCM-30)were treated with different concentrations(0.1, 1, 10, 100, 1 000, 10 000, 100 000 ng · mL^(-1)) of recombinant human AMG(rhAMG)and analyzed for proliferation, mineralization and mRNA expression of bone sialoprotein(BSP), osteocalcin(OCN), collagen type I(COL I), osteopontin(OPN), runt-related transcription factor 2(Runx2), cementum attachment protein(CAP), and alkaline phosphatase(ALP) genes using quantitative RT-PCR. The dose response of rhAMG was evaluated using a real-time cell analyzer.Total RNA was isolated on day 3, and cell mineralization was assessed using von Kossa staining on day 8. COL I, OPN and lysosomalassociated membrane protein-1(LAMP-1), which is a cell surface binding site for amelogenin, were evaluated using immunocytochemistry. F-actin bundles were imaged using confocal microscopy. rhAMG at a concentration of 100 000 ng · mL^(-1) increased cell proliferation after 72 h compared to the other concentrations and the untreated control group. rhAMG(100 000 ng · mL^(-1)) upregulated BSP and OCN mRNA expression levels eightfold and fivefold, respectively. rhAMG at a concentration of 100 000 ng · mL^(-1) remarkably enhanced LAMP-1 staining in cementoblasts. Increased numbers of mineralized nodules were observed at concentrations of 10 000 and 100 000 ng · mL^(-1) rhAMG. The present data suggest that rhAMG is a potent regulator of gene expression in cementoblasts and support the potential application of rhAMG in therapies aimed at fast regeneration of damaged periodontal tissue. | Sema S.Hakki S.Buket Bozkurt Emre Türkay Michel Dard Nuhan Purali Werner Gotz | 2018 | International Journal of Oral Science2018，10，2： | 3 |
| 3 | Frequency tunable microstrip patch antenna using RF MEMS technology显示文摘 | EMRE E KAGAN T MEHMET U | 2007 | IEEE Transactions on Antennas and Propagation2007，55，4： | 1 |
| 4 | Sparsity andcompressed sensing in radar imaging 显示文摘 | LEE C P ERTIN Emre PARKER J T | 2010 | Proceedings of the IEEE2010，98，6： | 1 |
| 5 | Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages显示文摘 | Emre Y Hurtaud C Nübel T | 2007 | Biochem J2007，402，2： | 1 |
| 6 | Uncoupling protein UCP2:when mitochondrialactivity meets immunity显示文摘 | Emre Y Nübel T | 2010 | FEBS Lett2010，584，8： | 1 |
| 7 | Tumor-cell homing to lymph nodes and bone marrow and CXCR4 expression in esophageal cancer显示文摘 | Jussuf T Kaifi Emre F | 2005 | J Nail Cancer Inst2005，97，24： | 1 |
| 8 | Increased plasma endothelin-1 levels in patients with progressive open angle glaucoma显示文摘 | Emre M Orgtll S Haufschild T | 2005 | J Ophthalmol2005，89，1： | 1 |
| 9 | Increased plasma endothelia-1 levels in patients with progressive open angle glaucoma 显示文摘 | Emre M Orgul S Haufschild T | 2005 | Br J Ophthalmol2005，89，1： | 1 |
| 10 | Antithrombotic treat- ment in the prevention of ischemie stroke显示文摘 | Emre U Rantanen K Tatlisumak T | 2007 | Curr Drug Tar- gets2007，8，7： | 1 |
| 11 | Location, location, location : membrane targeting directed by PX domains 显示文摘 | Sato T K Overduin M Emr S D | 2001 | Science2001，294，： | 1 |
| 12 | Capacity of multi-antenna gaussian channels显示文摘 | EMRE T | 1999 | European Transactions on Telecommunications1999，10，6： | 1 |
| 13 | Antithrombotie treatmentin the prevention of ischemic stroke 显示文摘 | Emre U Rantanen K Tatlisumak T | 2007 | Curr Drug Targets2007，8，7： | 1 |
| 14 | Increased plasma endothelin- 1 levels in patients with progressive open angle glaucoma显示文摘 | Emre M Orgul S Hanfschild T | 2005 | Br J Ophthaltool2005，89，1： | 1 |
| 15 | Clinical applications of bone graft substitutes显示文摘 | Safdar NK Emre T Joseph ML | 2000 | Orthop Clin North Am2000，31，3： | 1 |
| 16 | Increased plasma endothelin-1 levels in patients with progressive open angle glaucoma显示文摘 | Emre M Orgul S Haufschild T | 2005 | Br J Opthalmol2005，89，： | 1 |
| 17 | Uncoupling protein UCP2:when mitochondrial activity meets immunity显示文摘 | Emre Y Nübel T | | 0，，08： | 1 |
| 18 | Capacity of Multi-antenna Gaussian Channels 显示文摘 | Emre T | 1999 | European Transactions on Telecommunications1999，10，6： | 1 |
| 19 | Forced air cooling of CPUs with heat sinks: A numerical study显示文摘 | Emre O Ilker T | 2008 | IEEE Transactions on Components and Packaging Technologies2008，31，3： | 1 |
| 20 | In vitro reconstitu- tion of intercompartmental protein transport to the yeast vacuole 显示文摘 | Vida T A Graham T R Emr S D | 1990 | J Cell Biol1990，111，： | 1 |
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