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您的检索式：作者名="Eng King Tan"
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| 1 | Symbiotic bacteria attenuate Drosophila oviposition repellence to alkaline through acidification显示文摘Metazoans harbor a wealth of symbionts that are ever-changing the environment by taking up resources and/or excreting metabolites.One such common environmental modification is a change in pH.Conventional wisdom holds that symbionts facilitate the survival and production of their hosts in the wild,but this notion lacks empirical evidence.Here,we report that symbiotic bacteria in the genus Enterococcus attenuate the oviposition avoidance of alkaline environments in Drosophila.We studied the effects of alkalinity on oviposition preference for the first time,and found that flies are robustly disinclined to oviposit on alkali-containing substrates.This innate repulsion to alkaline environments is explained,in part,by the fact that alkalinity compromises the health and lifespan of both offspring and parent Drosophila.Enterococcus dramatically diminished or even completely reversed the ovipositional avoidance of alkalinity in Drosophila.Mechanistically,Enterococcus generate abundant lactate during fermentation,which neutralizes the residual alkali in an egg-laying substrate.In conclusion,Enterococcus protects Drosophila from alkali stress by acidifying the ovipositional substrate,and ultimately improves the fitness of the Drosophila population.Our results demonstrate that symbionts are profound factors in the Drosophila ovipositional decision,and extend our understanding of the intimate interactions between Drosophila and their symbionts. | Wei Liu Jie Wang Hong-Yu Zhang Ying-Chun Yang Ru-Xue Kang Peng Bai Hui Fu Li-Rong Chen Yan-Ping Gao Eng King Tan | 2021 | Insect Science2021，28，2： | 1 |
| 2 | Mild cognitive impairment in Parkinson’s disease:a distinct clinical entity?显示文摘Background:Mild cognitive impairment in Parkinson’s disease(PD-MCI)is a common clinical condition.Understanding its pathology and clinical features is important for early intervention before the onset of dementia.In the past,variable definitions and differences in neuropsychological batteries generated divergent results of the affected cognitive patterns.Main body:The introduction of PD-MCI criteria by the Movement Disorders Society(MDS)Task Force provides a more uniform system for defining and measuring PD-MCI and may improve the validity of future research.PD-MCI is likely to be heterogeneous since it can coexist with Alzheimer’s disease and/or Lewy body pathologies in PD.Pathogeneses of neuropsychiatric disturbances,such as depression,anxiety and apathy,are associated with PD with or without MCI.In addition,cognitive reserve formed by patients’unique life experiences may influence the outward cognitive performance despite the presence of the aforementioned pathogeneses and hence alter the diagnosis of MCI.Conclusion:The overlap of cognitive impairment across different neurodegenerative diseases suggests that PD-MCI is likely to result from a mixture of complex pathophysiologies,rather than being a distinct pathologic entity.Differentiating MCI from other organic symptoms in PD would facilitate novel therapeutic strategies. | Ming-Ching Wen Ling Ling Chan Louis C.S.Tan Eng King Tan | 2017 | Translational Neurodegeneration2017，6，1： | 0 |
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