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32篇 您的检索式：作者名="Engelman D M"

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	题名	作者	年代	出处	被引量
1	Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients显示文摘AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy.METHODS:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010.Data analyzed consisted of demographic and clinical variables.The brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were reviewed.Median age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant chemoradiotherapy.Pathological complete and partial responses were achieved in 17(19%) and 71(81%) patients.Cancer relapsed in 43/142(30%) patients.The brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following esophagectomy.Further studies will be required to validate this observation.	Taher Abu Hejleh Barry R DeYoung Eric Engelman Jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald Clamon	2012	World Journal of Gastrointestinal Oncology2012，4，5：	5
2	The evolution of diabetic response to ischemia/ reperfusion and preconditioning in isolated working rat heart显示文摘	TOSAKI A ENGELMEN D T ENGELMAN R M	1996	Cardiovasc Res1996，31，：	1
3	Designing automated computational fluid dynamics modeling tools for hydrocyclone design显示文摘	Slack M D Del Porte S Engelman M S	2004	Minerals Engineering2004，17，：	1
4	Tricuspid annuloplasty,Fiveand one-half years experience with 78 patients显示文摘	Boyd A D Engelman R M Isom O W	1974	Thorac Cardiovasc Surg1974，68，：	1
5	Constitutive nitric oxide release is impaired after is-chemia and reperfusion显示文摘	Engelman D T Watanabe M Engelman R M	1995	Thorac cardiovasc Surg1995，110，：	1
6	Angiotensin precon ditioning of the heart: evidence for redox signaling显示文摘	Das S Engelman R M Maulik N Das D K	2006	Cell Biochem Biophys2006，44，：	1
7	Motifs of serine and threonine can drive association of transmembrane helices 显示文摘	DAWSON J P WEINGER J S ENGELMAN D M	2002	J Mol Biol2002，316，：	1
8	Blood lipid and oxidative stress responses to soy protein with isoflavones and phytic acid in postmenopausal women显示文摘	ENGELMAN H M ALEKEL D L HANSON L N		0，，03：	1
9	Improvement of ischemia-reperfusion-induced myocardial dysfunction by modulating calcium overload using a novel,specific calmodulin antagonist,CGS9343B显示文摘	Das D K Engelman R M Prasad M R	1989	Biochem Pharmaeol1989，38，：	1
10	Hypoxic preconditioning preserves antioxidant reserve in the working rat heart显示文摘	Watanbe M Engelman R M	1995	Cardiovasc Res1995，29，：	1
11	Effects of soy isoflavones and phytate on homocysteine, C- reactive protein, and iron status in postmenopausal women 显示文摘	Engelman H M Alekel D L Hanson L N	2006	American Journal of Clinical Nutrition2006，84，：	1
12	Molecular adaptation of cellular defences following preconditioning of the heart by repeated ischaemia显示文摘	DAS D K ENGELMAN R M KIMURA Y	1993	Cardiovasc Res1993，27，4：	1
13	Clinical definition of acquired resist-ance to epidermal growth factor receptor tyrosine kinaseinhibitors in non-small-cell lung cancer显示文摘	Jackman D Pao W Riely G J Engelman J A Kris M G Janne P A	2010	J Clin On-col2010，28，：	1
14	Role of membrane phospholipids in myocardial injury induced by ischemia and reperfusion显示文摘	DAS D K ENGELMAN R M ROUSOU J A	1986	Am J Physiol Heart Circ Physiol1986，251，1：	1
15	Constitutive nitric oxide release is impaired after ischemia and reperfusion显示文摘	Engelman D T Watanabe M Engelman R M	1995	J Thorac Cardiovasc Surg1995，110，41：	1
16	Constitutive nitric oxide release is impaired after ischemia and reperfusion 显示文摘	Engelman D T Watanable M Engelman R M	1995	J Thorac Cardiovasc Surg1995，110，4：	1
17	Designing automated computational fluid dynamics modeling tools for hydrocyclone design 显示文摘	Slack M D Porte S D Engelman M S	2004	Minerals Engineering2004，17，5：	1
18	Identifying nonpolar transbilayer helices in amino acid sequences of membrane pro- teins 显示文摘	Engelman D M Steitz T A Goldman A	1986	Ann Rev Biophys Biophys Chem1986，15，：	1
19	The C-H …O hydrogen band:A determinant of stability and specificity in trans- membrane helix interactions显示文摘	SENES A UBARRETXENA-BELANDIA I ENGELMAN D M	2001	Proc Natl Acad Sci USA2001，98，16：	1
20	Designing Automated Computational Fluid Dynamics Modelling Tools for Hydrocyclone Design 显示文摘	SLACK M D Del Porte S ENGELMAN M S	2004	Minerals Engineering2004，，17：	1

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