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| 1 | Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients显示文摘AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy.METHODS:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010.Data analyzed consisted of demographic and clinical variables.The brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were reviewed.Median age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant chemoradiotherapy.Pathological complete and partial responses were achieved in 17(19%) and 71(81%) patients.Cancer relapsed in 43/142(30%) patients.The brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following esophagectomy.Further studies will be required to validate this observation. | Taher Abu Hejleh Barry R DeYoung Eric Engelman Jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald Clamon | 2012 | World Journal of Gastrointestinal Oncology2012，4，5： | 5 |
| 2 | MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling显示文摘 | ENGELMAN J A ZEJNULLAHU K MITSUDOMI T | 2007 | Science2007，316，5827： | 1 |
| 3 | Caveolin-3 null mice show a loss of caveolae,changes in the microdomain distribution of the dystrophin- glycoprotein complex,and t-tubule abnormalities显示文摘 | Galbiati F Engelman J A Volonte D | 2001 | The Journal of Biological Chemistry2001，276，21： | 1 |
| 4 | Clinical activity of crizotinib in patients with advanced non-small cell lung cancer (NSCLC) harboring ROS1 gene rearrangement 显示文摘 | Shaw AT Camidge DR Engelman J | 2012 | Ann Oncol2012，30，： | 1 |
| 5 | Mechanisms of acquired resistance to epidermal growth receptor tyrosine kinase inhibitors in non-small cell lung cancer显示文摘 | Engelman JA J(o)nne PA | | 0，，10： | 1 |
| 6 | Tar- geted down-regulation of caveolin-3 is sufficient to inhibit myotube formation in differentiating C2C12 myoblasts-transient activation of p38 mitogen- activated protein kinase is required for induction of caveolin-3 expression and subsequent myotube for- mation显示文摘 | Galbiati F Volonte D Engelman J A | 1999 | Journal of Biological Chemistry1999，274，30： | 1 |
| 7 | Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers 显示文摘 | Engelman J A Chert L Tan X | 2008 | Nat Med2008，14，12： | 1 |
| 8 | Azithromycin-resistantsyphilis infection:San Francisco,California,2000-2004显示文摘 | Mitchell SJ Engelman J Kent CA | 2006 | Clin In-fect Dis2006，42，： | 1 |
| 9 | Activity and safety of crizotinib in patients with ALK -positive non-small-cell lung cancer: updated results from a phase 1 study显示文摘 | D Ross Camidge Yung-Jue Bang Eunice L Kwak A John Iafrate Marileila Varella-Garcia Stephen B Fox Gregory J Riely Benjamin Solomon Sai-Hong I Ou Dong-Wan Kim Ravi Salgia Panagiotis Fidias Jeffrey A Engelman Leena Gandhi Pasi A J?nne Daniel B Costa Geoffrey | 2012 | Lancet Oncology2012，，10： | 1 |
| 10 | Azithromycin-Resistant syphilis infection: San Francisco, California, 2000- 2004 显示文摘 | Mitchell SJ Engelman J Kent CK | 2006 | ClinInfect Dis2006，42，3： | 1 |
| 11 | Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer显示文摘 | Engelman J A Janne P A | | 0，，10： | 1 |
| 12 | Human population in the biodiversity hotspots显示文摘 | Cincotta RP Wisnewski J Engelman R 2000 | 2000 | Nature2000，404，： | 1 |
| 13 | Azithromycin resist ant syphilis infection: San Francisco, California, 2000-2004显示文摘 | Mitchell SJ Engelman J Kentet CK | 2006 | Clinical Infectious Diseases2006，42，3： | 1 |
| 14 | MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling显示文摘 | ENGELMAN J A ZEJNULLAHU K MITSUDOMI T | 2007 | Science2007，316，5827： | 1 |
| 15 | MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling显示文摘 | ENGELMAN J A ZEJNULLAHU K MITSUDOMI T | 2007 | Science2007，316，5827： | 1 |
| 16 | Targeting PI3K signalling in cancer:opportunities,challenges and limitations显示文摘 | ENGELMAN J A | 2009 | Nat Rev Cancer2009，9，8： | 1 |
| 17 | The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism显示文摘 | Engelman JA Luo J Cantley LC | 2006 | Nat Rev Genet2006，7，8： | 1 |
| 18 | Azithromycin-resistant syphilis infection;San Francisco,California,2000-2004显示文摘 | Mitchell SJ Engelman J Kent CK | 2006 | Clinical infectious diseases:an official publication of the Infectious Diseases Society of America2006，42，3： | 1 |
| 19 | The evolution of phosphati- dylinositol 3-kinases as regulators of growth and metabolism 显示文摘 | Engelman JA Luo J Cantley LC | 2006 | Nat Rev Genet2006，7，8： | 1 |
| 20 | Ketamine has no effect on bispectral index during stable propofol-remifentanil anaesthesia显示文摘 | FARAONI D SALENGROS J C ENGELMAN E | 2009 | Br J Anaesth2009，102，3： | 1 |
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