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| 1 | Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer显示文摘Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer. | Jonathan Landy Emma Ronde Nick English Sue K Clark Ailsa L Hart Stella C Knight Paul J Ciclitira Hafid Omar Al-Hassi | 2016 | World Journal of Gastroenterology2016，22，11： | 39 |
| 2 | Characterization of colonic dendritic cells in normal and colitic mice显示文摘AIM: Recent studies demonstrating the direct involvement of dendritic cells (DC) in the activation of pathogenic T cells in animal models of inflammatory bowel disease identify DC as important antigen presenting cells in the colon. However, very little is known about the properties of colonic DC.METHODS: Using immunohistochemistry, electron microscopy and flow cytometry we have characterized and compared colonic DC in the colon of healthy animals and interleukin-2-deficient (IL2-/-) mice that develop colitis.RESULTS: In the healthy colon, DC resided within the lamina propria and in close association with the basement membrane of colonic villi. Type 1 myeloid (CD11c+, CD11b+,B220-, CD8α-) DC made up the largest (40-45%) population and all DC expressed low levels of CD80, CD86, and CD40,and had high endocytic activity consistent with an immature phenotype. In colitic IL2-/- mice, colonic DC numbers increased four- to five-fold and were localized within the epithelial layer and within aggregates of T and B cells. They were also many more DC in mesenteric lymph nodes (MLN).The majority (>85%) of DC in the colon and MLN of IL2-/-mice were type 1 myeloid, and expressed high levels of MHC class Ⅱ, CD80, CD86, CD 40, DEC 205, and CCR5molecules and were of low endocytic activity consistent with mature DC.CONCLUSION: These findings demonstrate striking changes in the number, distribution and phenotype of DC in the inflamed colon. Their intimate association with lymphocytes in the colon and draining lymph nodes suggest that they may contribute directly to the ongoing inflammation in the colon. | Sheena M Cruickshank Nicholas R English Peter J Felsburg Simon R Carding | 2005 | World Journal of Gastroenterology2005，11，40： | 3 |
| 3 | Response of circulating tumor cells to systemic therapy in patients with metastatic breast cancer: comparison of quantitative polymerase chain reaction and immunocytochemical techniques显示文摘 | Slade MJ English J | 2000 | J Clin Oncol2000，18，7： | 1 |
| 4 | Suppression of virus accumulation in transgenic plants exhibiting silencing of nuclear gene 显示文摘 | English J J Mueller E Baulcombe D C | 1996 | Plant Cell1996，8，： | 1 |
| 5 | Examining the contribution of glacial till water to storm runoff using two and three-component hy-drograph separations 显示文摘 | Hinton M J Schiff S L English M C | 1994 | Water Resource Research1994，30，： | 1 |
| 6 | New insights into the control of MAP kinase pathways 显示文摘 | English J Pearson G Wilsbacher J | 1999 | Exp Cell Res1999，253，1： | 1 |
| 7 | How accurate is CT angiography in evaluating intracranial atherosclerotic disease显示文摘 | Nguyen-Huynh MN Wintermark M English J | 2008 | Stroke2008，39，4： | 1 |
| 8 | Isolation of thermophiles from broadleaf tobacco and effect of pure culture inoculation on cigar aroma and mildness显示文摘 | English C F Bell E J Berger A J | 1967 | Application Microbiology1967，15，： | 1 |
| 9 | The role of PET and PET/CT in managing the care of lymphoma patients显示文摘 | Evans WC Gilmore D English J | 2011 | J Nucl Med Technol2011，39，3： | 1 |
| 10 | The role of platelet-activating factor in regional myocardial ischemiareperfusion injury显示文摘 | Qayumi A K English J C Godin D V | 1998 | Arm Thorac Surg1998，65，： | 1 |
| 11 | Enhancing and tuning pho- non transport at vibrationally mismatched solid-solid interfhces显示文摘 | English T S Duda J C Smoyer J L | 2012 | Physics Review B2012，85，03： | 1 |
| 12 | Isolation of thermophiles from brood leaf tobacco and effect of pure ulture inoculation on cigar aroma and mildness显示文摘 | English C F Bell E J Berger A J | 1967 | Ape Microbio1967，，15： | 1 |
| 13 | Submarine rescue systems: An international priority using BC technology 显示文摘 | English J | 2003 | Innovation2003，7，4： | 1 |
| 14 | The role of oxygen in the antiviral activity of hypericin and hypocrellin显示文摘 | PARK J ENGLISH D S WANNEMUEHLER Y | 1998 | Photochem Photobiol1998，68，4： | 1 |
| 15 | Systematic review and meta-analysis of different dietary approaches to the management of type 2 diabetes显示文摘 | Ajala O English P Pinkney J | 2013 | Am J Clin Nutr2013，97，3： | 1 |
| 16 | Systematic review and meta-analysis of different dietary approaches to the management of type 2 diabetes显示文摘 | Ajala O English P Pinkney J | 2013 | Am J Clin Nutr2013，97，3： | 1 |
| 17 | Foodfails to suppress ghrelin levels in obese humans 显示文摘 | ENGLISH P J GHATEI M A MALIK I A | 2002 | The Journal of Clinical Endocrinology & Metabolism2002，87，6： | 1 |
| 18 | Detection of Phytophthora parasitica from soil and host tissue with a species-specific DNA probe显示文摘 | English J T Nehther D A | 1990 | Phytopathology1990，80，： | 1 |
| 19 | RheologyAnd photo-cross-linking of thiol-ene polymers 显示文摘 | Bor-Sen C English R J SaadA K | 1996 | Macromolecules1996，29，16： | 1 |
| 20 | Influence of an introduced com- posite of microorganisms on infection of tobacco by Phyto- phthora parasitica vat,nicotianae显示文摘 | English J T Mitchell D J | | 0，，： | 1 |
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