| 1 | Evolution of GCGR family ligand-receptor extensive cross-interaction systems suggests a therapeutic direction for hyperglycemia in mammals显示文摘Glucose is essential to the physiological processes of vertebrates.Mammalian physiological stability requires a relatively stable blood glucose level(~5 mM),whereas other vertebrates have greater flexibility in regulating blood glucose(0.5–25 mM).GCGR family receptors play an important role in vertebrate glucose regulation.Here,we examine the evolution of the GCGR family ligand-receptor systems in different species.Comparatively,we discover that the conserved sequences among GCG family ligands lead to the non-specific activation of ligands across species.In particular,we observe that glucagon-like peptide 1 receptor(GLP1R),glucagon-like peptide 2 receptor(GLP2R),and glucagon-like receptor(GCGLR,also called GCRPR)are arbitrarily activated by other members of the ligand family in birds.Moreover,we reveal that Gallus gallus GLP2(gGLP2)effectively activates mammalian GLP1R and improves glucose tolerance in diabetic mice.Our study has important implications for understanding blood glucose stabilization in vertebrates and demonstrates that gGLP2 may be a potential drug for treating type 2 diabetes. | Jian Liu Xue Wang Wenli Zhang Guangneng Liao Zhenhua Shao Juergen Brosius Cheng Deng Shanshan Lai Enwu Long | 2023 | Acta Biochimica et Biophysica Sinica2023，55，12： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员