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| 1 | 酒精对男性生殖功能有何影响?一个文献综述显示文摘酒精被广泛使用,而其对男性生殖功能的影响仍然存在争议。多年来,已经有许多研究调查了酒精对精子参数男性不育症的影响。本文综述了主要的临床前和临床证据。对实验动物进行的研究已经表明,富含乙醇的饮食会导致精子参数异常,导致很多改变,包括抑制生殖道,降低小鼠卵母细胞体外受精率。这些影响在停止酒精消费后是部分可逆的。大多数研究显示酒精对男性参数呈现负面影响。这已被报道与低睾酮症和低于正常和升高的促性腺激素水平有关,暗示着一个联合中枢的、酒精产生的睾丸损害效应。然而,饮洒似乎并没有对生育有太大的影响,无论是在体外授精过程中还是在基于人口的研究中。最后,遗传背景和其他因素,饮酒相关情况会影响睾丸损害的程度。总之,饮酒与精子参数的恶化有关,且这种恶化在停止饮酒后部分可逆。 | Sandro La Vignera Rosita A Condorelli Giancarlo Balercia Enzo Vicari Aldo E Calogero | 2013 | Asian Journal of Andrology2013，15，2： | 9 |
| 2 | Soluble ST2:A new and promising activity marker in ulcerative colitis显示文摘AIM:To correlate circulating soluble ST2(sST2) levels with the severity of ulcerative colitis(UC) and serum levels of pro-inflammatory cytokines,and to demonstrate the predictive power of sST2 levels for differentiation between active and inactive UC.METHODS:We recruited 153 patients:82 with UC,26 with Crohn's disease(CD) and 43 disease controls [non-inflammatory bowel disease(IBD)].Subjects were excluded if they had diagnosis of asthma,autoimmune diseases or hypertension.The serum levels of sST2 and pro-inflammatory cytokines [pg/mL;median(25th-75th)] as well as clinical features,endoscopic and histological features,were subjected to analyses.The sST2 performance for discrimination between active and inactive UC,non-IBD and healthy controls(HC) was determined with regard to sensitivity and specificity,and Spearman's rank correlation coefficient(r).To validate the method,the area under the curve(AUC) of receiver-operator characteristic(ROC) was determined(AUC,95% CI) and the total ST2 content of the colonic mucosa in UC patients was correlated with circulating levels of sST2.RESULTS:The serum sST2 value was significantly higher in patients with active [235.80(90.65-367.90) pg/mL] rather than inactive UC [33.19(20.04-65.32) pg/mL],based on clinical,endoscopic and histopathological characteristics,as well as compared with non-IBD and HC(P < 0.001).The median level of sST2 in CD patients was 54.17(35.02-122.0) pg/mL,significantly higher than that of the HC group only(P < 0.01).The cutoff was set at 74.87 pg/mL to compare active with inactive UC in a multicenter cohort of patients.Values of sensitivity,specificity,and ability to correctly classify UC,according to activity,were 83.33%,83.33% and 83.33%,respectively.The AUC of the ROC curve to assess the ability of this molecule to discriminate between active vs inactive UC was 0.92(0.86-0.97,P < 0.0001).The serum levels of sST2 in patients with UC significantly correlated with endoscopic and histo-pathological scores(r = 0.76 and r = 0.67,P < 0.0001,respectively),and with the pro-inflammatory cytokine,tumor necrosis factor-α(r = 0.69 and r = 0.61,respectively,P < 0.0001).Interestingly,we found a direct correlation between total intestinal ST2 content and serum levels of sST2,adjusted to endoscopic activity score in patients with mild(r = 0.44,P = 0.004),moderate(r = 0.59,P = 0.002) and severe disease(r = 0.82,P = 0.002).Only patients with inactive UC showed no significant correlation(r = 0.45,P = 0.267).CONCLUSION:sST2 levels correlated with disease severity and inflammatory cytokines,are able to differentiate active from inactive UC and might have a role as a biomarker. | David Díaz-Jiménez Lucía E Núez Caroll J Beltrán Enzo Candia Cristóbal Suazo Manuel varez-Lobos María-Julieta González Marcela A Hermoso Rodrigo Quera | 2011 | World Journal of Gastroenterology2011，17，17： | 8 |
| 3 | Seminal vesicles and diabetic neuropathy: ultrasound evaluation in patients with couple infertility and different levels of glycaemic control显示文摘这研究的目的是与糖尿病 mellitus (DM ) 和糖尿病的神经病(DN ) 评估不肥沃的病人的精囊(SV ) 的超声特征并且在与 glycaemic 控制有关的超声特征调查可能的变化。完成这,有类型 2 DM 的 45 个不肥沃的病人和征兆的 DN 被选择。有没有 DM 的自发的 oligoasthenoteratozoospermia 的二十个健康的肥沃的人和 20 个病人代表了控制组。DM 病人任意地根据 glycaemic 控制水平被划分成三个组(A=glycosylated 血色素 < 7 %在 7 % 之间的 B=glycosylated 血色素;并且 10 %C=glycosylated 血色素 > 10 %) 。病人们经历了前列腺小囊的 transrectal ultrasonography 和精子分析。下列 SV 超声参数被记录:(i) 身体 antero 以后的直径(APD ) ;(ii ) 宫底 APD;(iii ) 正确、左的 SV 的顶骨厚度;并且(iv ) 在两 SV 以内的多不的区域的数字。我们然后计算了下列参数:(i) 宫底 / 身体(F/B ) 比率;(ii ) 在权利和左 SV 之间的顶骨厚度的差别;并且(iii )pre 射精并且 ejaculatory 以后 APD 差别。所有 DM 病人与控制相比有更高的 F/B 比率(P< 0.05 ) 。组 C 与另外的 DM 组相比有更高的 F/B 比率(P< 0.05 ) 。有的所有 DM 病人一更低 pre 射精并且与控制相比的身体 SV APD 的 ejaculatory 以后差别(P< 0.05 ) 。组 A 和 B 有一类似 pre 射精并且身体 SV APD 的 ejaculatory 以后差别,而这差别在组 C 是更低的(P< 0.05 ) 。在结论,有 DN 的不肥沃的 DM 病人显示出功能的弛缓暗示的古怪 SV 超声特征,并且低 glycaemic 控制与这些特征的更大的表示被联系。 | Sandro La Vignera Rosita A Condorelli Enzo Vicari Rosario D'Agata Aldo E Calogero | 2011 | Asian Journal of Andrology2011，13，6： | 8 |
| 4 | 伴随自主神经病变的二型糖尿病人中雄附腺炎症的发病率显示文摘雄附腺炎(MAGI)在二型糖尿病人(DM2)当中可能被漏诊。近期文献报道TDM2中MAGI的发病率是43%。以往的研究证明糖尿病患者的自主神经病变与精子囊泡的特有超声波有关。本项研究意在评估二类DM2患者(是否具有自主神经病变)的MAGI发病率并测定各自的超声特征。共60例DM2患者(平均年龄42.0±6.0岁)根据是否具有自主神经病变分为二组(A组具有可能的神经病变症状共28人,B组无神经病变症状共32人)。结果发现A组较B组有更高的MAGI发病率及精囊炎的超声频率。此外,A组患者精液中的淋巴细胞聚焦浓度显著高于B组。 | Rosita A Condorelli Enzo Vicari Aldo E Calogero Sandro La Vignera | 2014 | Asian Journal of Andrology2014，16，5： | 6 |
| 5 | Acquired premature ejaculation and male accessory gland infection: relevance of ultrasound examination显示文摘我们以前与男附件腺感染(东方三博士) 在病人之中表明了早泄(PE ) 的高频率。这研究的目的是评估有东方三博士和获得的早泄(无尾猿) 的病人的特征联系了的超声(美国)(MAGI-APEpos ) 。与有没有代表控制组的 PE (MAGI-PEneg ) 的东方三博士的 50 个病人相比的 50 个 MAGI-APEpos 病人的美国评估。无尾猿的诊断通过 Intravaginal 射精潜伏时间(IELT ) 的评估被做并且与问询表 PEDT (早泄诊断工具) 证实了。主要结果措施被暗示的美国标准的频率代表 P (前列腺炎) , V (vesiculitis ) ,和在 MAGI-APEpos 和 MAGI-PEneg 病人的 E (附睾炎) 。MAGI-APEpos 病人显示出与 MAGI-PEneg 病人相比显著地更高的美国标准的一个全部的数字。MAGI-APEpos 显示出 V 和 E (东方三博士的复杂形式) 的美国标准的更高的频率。在 MAGI-APEpos 组,最后,它被发现在 epididymis 的尾的道和精囊的 APD 的 anteroposterior 直径(APD ) 之间,以及在直径和 PEDT 分数之间的一种积极关系。MAGI-APEpos 病人与 MAGI-PEneg 病人相比有古怪美国描述。根据这些结果, epididymal 并且小囊的道应该与东方三博士和无尾猿在病人的实际临床的途径被考虑的 prostato 的美国评估。特别地,它能是对在这些病人的这个临床的问题的可能的 pathophysiological 解释的支持。 | Sandro La Vignera Rosita A Condorelli Enzo Vicari Vincenzo Favilla Giuseppe Morgia Aldo E Calogero | 2016 | Asian Journal of Andrology2016，18，5： | 5 |
| 6 | 慢性细菌性前列腺炎和肠易激综合征:利福昔明联合益生菌VSL#3的治疗效果显示文摘本研究评价了利福昔明联合益生菌VSL#3对慢性前列腺炎转化为微生物性前列腺精囊炎(PV)或前列腺精囊附睾炎(PVE)的作用。106例伴有细菌学治愈的慢性细胞性前列腺炎和肠易激综合征的男性不育患者随机予以利福昔明(200mg,20:/日,每月服用7日,持续12个月)和益生菌VSL#3(450×10^9CFU/日)治疗及无处理。95名患者(89.6%)完成治疗计划,纳入本研究。将患者分为四组:A组前6个月予治疗,后6月无治疗(n=26);B组予12个月治疗(n=22);C组前6个月不予治疗后6个月予治疗(n=23);D组在12个月内均无治疗(n=24)。A组和B组患者慢性前列腺炎发生率最高(分别为88.5%和86.4%)。相反,D组患者前列腺炎发生率最低(33.4%)。前列腺炎进展为PV的发生率在B组(15.5%)和C组(13.6%)低于D组(45.8%)。B组和C组最终无患者进展为PVE,而D组有20.8%诊断为PVE。长期服用利福昔明联合益生菌VSL#3能有效降低伴有治愈的CBP伴IBS的男性不育患者的前列腺炎进展为更复杂形式的男性附属性腺感染。 | Enzo Vicari Sandro La Vignera Roberto Castiglione Rosita A Condorelli Lucia O Vicari Aldo E Calogero | 2014 | Asian Journal of Andrology2014，16，5： | 3 |
| 7 | In vivo synchrotron study of thallium speciation and compart- mentation in lberis intermedia 显示文摘 | Kirk G Scheckel Enzo Lombi Steven A Rock | 2004 | Environment Science Technology2004，38，19： | 1 |
| 8 | Differentiation of the epidermis in turtle: an immunocytochemical, autoradiographic and electrophoretic analysis 显示文摘 | Lorenzo A Enzo S Mattia T | 2004 | Acta Histochemica2004，106，5： | 1 |
| 9 | Food preservative based on propolis:Bacteriostatic activity of propolis polyphenols and flavonoids upon Escherichia col显示文摘 | Enzo A T Edmundo R Marta E O | 2007 | Food Chemistry2007，1025，： | 1 |
| 10 | Application of fitting Techniques to the Warren-Averbach method for X-ray line broadening analysis显示文摘 | ENZO S POLIZZI S BENEDETTI A | 1985 | Rivista Zeitschrift Fur Kristallographie1985，170，14： | 1 |
| 11 | The Pinb-2 genes in wheat comprise a muhigene family with great sequence diversity and im- portant variants显示文摘 | Ramalingam A Enzo A Bhave M | 2012 | J Cereal Sei2012，56，： | 1 |
| 12 | Anti-listerial aetlvity of ethanolie extracts of medicinal plants, Eremophila alternifolia and Eremophila duttonii, in food homggenates and milk 显示文摘 | ROXANNE J OWEN ENZO A | 2007 | Food Control2007，18，： | 1 |
| 13 | Anti - listerial activity of ethanolic extracts of medicinal plants, Eremophila alternifolia and Eremophila duttonii, in food homogenates and milk 显示文摘 | Roxanne J Owen Enzo A | 2007 | Food Control2007，18，： | 1 |
| 14 | Food preservative based on propolis: Bacteriostatic activity of propolis polyphenols and flavonoids upon Escherichia coli 显示文摘 | Enzo A Tosi Edmundo Re' Marta E Ortega | 2007 | Food Chemistry2007，104，： | 1 |
| 15 | Comparison Of two HFLC systems and an enzymatic method for quantification of soybean sugars显示文摘 | Enzo Giannoccaro Ya-Jane Wang a Pengyin Chen | 2008 | Food Chemistry2008，106，： | 1 |
| 16 | Heavy Metal Phytoremediation Potential of a Heavy Metal Resistant Soil Bacterial Isolate, Achromobaeter sp显示文摘 | Russell Stanbrough Saifone Chuaboonmee Enzo A Palombo | 2013 | Strain AO22 APCBEE Proeedia2013，，5： | 1 |
| 17 | Angiogenesis and antiangiogenic agents in non-small cell lung cancer显示文摘 | Enzo G Ferro A | 2001 | Lung Cancer2001，34，： | 1 |
| 18 | Food preservative based on propolis: Bacteriostatic activity of propolis polyphenols and flavonoids upon Escherichia coli显示文摘 | Enzo A Tosi Edmundo Re Marta E Ortega | 2007 | Food Chemistry2007，104，： | 1 |
| 19 | Amorphous/Nanocrystalline Composites Analysed by the Rietveld Method显示文摘 | Baricco M Enzo S Baser T A | 2010 | Journal of Alloys and Compounds2010，495，2： | 1 |
| 20 | A Transmit-OnlyReceive-Only (TORO) RF system for high-field MRIMRS applications显示文摘 | Enzo A B Joseph S G Brian K R | 2000 | Magn Reson Med2000，43，2： | 1 |
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