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| 1 | Peritoneal carcinomatosis of colorectal origin:Incidence,prognosis and treatment options显示文摘Peritoneal carcinomatosis (PC) is one manifestation of metastatic colorectal cancer (CRC). Tumor growth on intestinal surfaces and associated fluid accumulation eventually result in bowel obstruction and incapacitating levels of ascites, which profoundly affect the quality of life for affected patients. PC appears resistant to traditional 5-fluorouracil-based chemotherapy, and surgery was formerly reserved for palliative purposes only. In the absence of effective treatment, the histori-cal prognosis for these patients was extremely poor, with an invariably fatal outcome. These poor outcomes likely explain why PC secondary to CRC has received little attention from oncologic researchers. Thus, data are lacking regarding incidence, clinical disease course, and accurate treatment evaluation for patients with PC. Recently, population-based studies have revealed that PC occurs relatively frequently among patients withCRC. Risk factors for developing PC have been identi-fied:right-sided tumor, advanced T-stage, advanced N-stage, poor differentiation grade, and younger age at diagnosis. During the past decade, both chemother-apeutical and surgical treatments have achieved prom-ising results in these patients. A chance for long-term survival or even cure may now be offered to selected patients by combining radical surgical resection with intraperitoneal instillation of heated chemotherapy. This combined procedure has become known as hy-perthermic intraperitoneal chemotherapy. This edito-rial outlines recent advancements in the medical and surgical treatment of PC and reviews the most recent information on incidence and prognosis of this disease. Given recent progress, treatment should now be considered in every patient presenting with PC. | Yvonne LB Klaver Valery EPP Lemmens Simon W Nienhuijs Misha DP Luyer Ignace HJT de Hingh | 2012 | World Journal of Gastroenterology2012，18，39： | 9 |
| 2 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 3 | Kinetics and inhibition of lipid exchange catalyzed by plasma cholesteryl ester transfer protein (lipid transfer protein) 显示文摘 | Epps DE Greenlee KA Harris JS | 1995 | Biochemistry1995，34，12： | 2 |
| 4 | Phase Ⅱ study of docetaxel,cisplatin and capecitabine as preoperative chemotherapy in resectable gastric cancer显示文摘AIM To investigate the feasibility of preoperative docetaxel,cisplatin and capecitabine(DCC) in patients with resectable gastric cancer.METHODS Patients with resectable gastric cancer fulfilling the inclusion criteria,were treated with 4 cycles of docetaxel(60 mg/m2),cisplatin(60 mg/m2) and capecitabine(1.875 mg/m2 orally on day 1-14,two daily doses) repeated every three weeks,followed by surgery.Primary end point was the feasibility and toxicity/safety profile of DCC,secondary endpoints were pathological complete resection rate and pathological complete response(p CR) rate.RESULTS All of the patients(51) were assessable for the feasibility and safety of the regimen.The entire preoperative regimen was completed by 68.6% of the patients.Grade Ⅲ/Ⅳ febrile neutropenia occurred in 10% of all courses.Three patients died due to treatment related toxicity(5.9%),one of them(also) because of refusing further treatment for toxicity.Of the 45 patients who were evaluable for secondary endpoints,four developed metastatic disease and 76.5% received a curative resection.In 3 patients a p CR was seen(5.9%),two patients underwent a R1 resection(3.9%).CONCLUSION Four courses of DCC as a preoperative regimen for patients with primarily resectable gastric cancer is highly demanding.The high occurrence of febrile neutropenia is of concern.To decrease the occurrence of febrile neutropenia the prophylactic use of granulocyte colonystimulating factor(G-CSF) should be explored.A curative resection rate of 76.5% is acceptable.The use of DCC without G-CSF support as preoperative regimen in resectable gastric cancer is debatable. | Anneriet E Dassen Nienke Bernards Valery EPP Lemmens Yes AJ van de Wouw Koop Bosscha Geert-Jan Creemers Hans JFM Pruijt | 2016 | World Journal of Gastrointestinal Surgery2016，8，10： | 1 |
| 5 | Neutrophil and monocyte alterations in chronic dialysis patients显示文摘 | Lewis SL Van Epps DE | | 0，，05： | 1 |
| 6 | DR-CALUX screening of food samples:evaluation of the quantitative approach to measure dioxin,furans and dioxin-like PCBs显示文摘 | Scippo M L Eppe G De Pauw E | 2004 | Talanta2004，63，5： | 1 |
| 7 | Neutrophil and monocyte alterations in chronic dialysis patients显示文摘 | Lewis SL Van Epps DE | | 0，，： | 1 |
| 8 | Opioid peptides modulate production of interferon gamma by human mononuclearcells显示文摘 | Brown SL Van Epps DE | 1986 | Cell Immunol1986，103，： | 1 |
| 9 | High-throughput biomonitoring of dioxins and polychlorinated biphenyls at the sub-picogram level in human serum 显示文摘 | Focant J F Eppe G Massart A C Scholl G Pirard C Pauw C De Pauw E | 2006 | Journal of Chromatography A2006，1130，1： | 1 |
| 10 | Site-specific chemical modification of interleukin-1 beta by acrylodan at cysteine 8 and lysine 103显示文摘 | Yem AW Epps DE Mathews WR | 1992 | J Biol Chem1992，267，： | 1 |
| 11 | Optimization and use of tandem-in-time mass spectrometry in comparison with immunoassay and HRGC/HRMS for PCDD/F screening显示文摘 | FOCANTE J F EPPE G DE P E | 2001 | Chemosphere2001，43，： | 1 |
| 12 | Plasticizersinfant nutrition and reproductive health显示文摘 | Gius De Felice eppe Latini Claudio Alberto Verrotti | 2004 | Reproductive Toxicology2004，19，1： | 1 |
| 13 | DR-CALUX screening of food samples : evaluation of the quantitative approach to measure dioxin furans and dioxin-like PCBs 显示文摘 | SCIPPO bl L EPPE G DE P E | 2004 | Talanta2004，63，： | 1 |
| 14 | Demonstration of specific receptors for fluoresceinated casein on human neutrophils and mono- cytes using flow cytometry显示文摘 | Lewis SL Van Epps DE | 1983 | Inflammation1983，7，4： | 1 |
| 15 | Opioid peptides modulate production of inter- feron gamma by human mononuclear cells显示文摘 | Brown SL Van Epps DE | 1986 | Cell Immunol1986，103，1： | 1 |
| 16 | Specific active immunotherapy of cancer:potential and perspectives显示文摘 | Srinivasan R Van Epps DE | 2006 | Rev Recent Clin Trials2006，1，3： | 1 |
| 17 | Optimisation and use of tandem-in-time mass spectrometry in comparison with immunoassay and HRGC/HRMS for PCDD/F screening显示文摘 | J.-F Focant G Eppe E De Pauw | 2001 | Chemosphere2001，，4： | 1 |
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