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| 1 | Nanotechnology-based combination therapy for overcoming multidrug-resistant cancer显示文摘Multidrug resistance(MDR) is a major obstacle to successful cancer treatment and is crucial to cancer metastasis and relapse.Combination therapy is an effective strategy for overcoming MDR. However, the different pharmacokinetic(PK) profiles of combined drugs often undermine the combination effect in vivo, especially when greatly different physicochemical properties(e.g.,those of macromolecules and small drugs) combine. To address this issue, nanotechnology-based codelivery techniques have been actively explored. They possess great advantages for tumor targeting, controlled drug release, and identical drug PK profiles. Thus,a powerful tool for combination therapy is provided, and the translation from in vitro to in vivo is facilitated. In this review, we present a summary of various combination strategies for overcoming MDR and the nanotechnology-based combination therapy. | Meng Zhang Ergang Liu Yanna Cui Yongzhuo Huang | 2017 | Cancer Biology & Medicine2017，14，3： | 10 |
| 2 | Effect of the Transient Response in Si/Ge Parallelizing PN Junction显示文摘There are some new results about photovoltaic transient response in the new effect. We suggest a theoretical model to explain the effect reasonably. The theoretical calculation results agree with that in experiments. | Weiqi HUANGt and Chaogang CHEN(Department of Physics, Guizhou Educational College, Guiyan 550003, China)Ergang CHEN(Department of Physics, Yunnan University, Kunming 650091, China)To whom correspondence should be addressed | 1999 | Journal of Materials Science & Technology1999，15，4： | 10 |
| 3 | Tat-functionalized Ag-Fe_3O_4 nano-composites as tissue-penetrating vehicles for tumor magnetic targeting and drug delivery显示文摘In this paper, we prepared a dual functional system based on dextrin-coated silver nanoparticles which were further attached with iron oxide nanoparticles and cell penetrating peptide(Tat), producing Tat-modified Ag-Fe_3O_4 nanocomposites(Tat-FeAgNPs). To load drugs, an –SH containing linker, 3-mercaptopropanohydrazide, was designed and synthesized. It enabled the silver carriers to load and release doxorubicin(Dox) in a pH-sensitive pattern. The delivery efficiency of this system was assessed in vitro using MCF-7 cells, and in vivo using null BalB/c mice bearing MCF-7 xenograft tumors. Our results demonstrated that both Tat and externally applied magnetic field could promote cellular uptake and consequently the cytotoxicity of doxorubicin-loaded nanoparticles,with the IC_(50) of Tat-FeAgNP-Dox to be 0.63 mmol/L. The in vivo delivery efficiency of Tat-FeAgNP carrying Cy5 to the mouse tumor was analyzed using the in vivo optical imaging tests, in which TatFeAgNP-Cy5 yielded the most efficient accumulation in the tumor(6.772.4% ID of Tat-FeAgNPs).Anti-tumor assessment also demonstrated that Tat-FeAgNP-Dox displayed the most significant tumor-inhibiting effects and reduced the specific growth rate of tumor by 29.6%(P ? 0.009), which could be attributed to its superior performance in tumor drug delivery in comparison with the control nanovehicles. | Ergang Liu Meng Zhang Hui Cui Junbo Gong Yongzhuo Huang Jianxin Wang Yanna Cui Weibing Dong Lu Sun Huining He Victor C.Yang | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 5 |
| 4 | Nose-to-brain delivery of macromolecules mediated by cell-penetrating peptides显示文摘Brain delivery of macromolecular therapeutics(e.g., proteins) remains an unsolved problem because of the formidable blood–brain barrier(BBB). Although a direct pathway of nose-to-brain transfer provides an answer to circumventing the BBB and has already been intensively investigated for brain delivery of small drugs,new challenges arise for intranasal delivery of proteins because of their larger size and hydrophilicity. In order to overcome the barriers and take advantage of available pathways(e.g., epithelial tight junctions, uptake by olfactory neurons, transport into brain tissues, and intra-brain diffusion), a low molecular weight protamine(LMWP) cell-penetrating peptide was utilized to facilitate nose-to-brain transport. Cell-penetrating peptides(CPP)have been widely used to mediate macromolecular delivery through many kinds of biobarriers. Our results show that conjugates of LMWP–proteins are able to effectively penetrate into the brain after intranasal administration.The CPP-based intranasal method highlights a promising solution for protein therapy of brain diseases. | Tingting Lin Ergang Liu Huining He Meong Cheol Shin Cheol Moon Victor C.Yang Yongzhuo Huang | 2016 | Acta Pharmaceutica Sinica B2016，6，4： | 4 |
| 5 | A Review of Comminution Age Method and Its Potential Application in the East China Sea to Constrain the Time Scale of Sediment Source-to-Sink Process显示文摘The East China Sea(ECS) is a river-dominated epicontinental sea, linking the Asian continent to the northwestern Pacific via the large rivers originating from Tibetan Plateau. The relevant huge influx of riverine detritus has developed unique sedimentary systems in the ECS during the Quaternary, offering ideal terrestrial archives for reconstructing Quaternary paleoenvironmental changes and studying land-sea interactions. Overall, two characteristic river systems dominate the sedimentary systems and sediment source to sink transport patterns in the ECS, represented by the Changjiang(Yangtze River) and Huanghe(Yellow River) for the large river system and Taiwan rivers for the small river system. Given this, the sediments derived from both river systems bear distinct features in terms of parent rock lithology, provenance weathering and sediment transport. Previous studies mostly focus on either the ‘source' discrimination or the ‘sink' records of the sedimentary system in the ECS, while the source to sink process linking the land and sea, in particular its time scale, has been poorly understood. Here we introduce a newly-developed dating technique, the ‘comminution age' method, which offers a quantitative constraint on the time scale of sediment transfer from its ultimate source to the final depositional sink. This novel method is of great significance for improving our understanding on the earth surface processes including tectonic-climate driven weathering, and sediment recycling in relation to landscape evolution and marine environmental changes. The application of comminution age method in the ECS will provide important constraints on sediment source-to-sink process and more evidences for the construction of late Quaternary paleoenvironmental changes under these unique sedimentary systems. | LI Chao YANG Shouye LIAN Ergang BI Lei ZHANG Zhaofeng | 2015 | Journal of Ocean University of China2015，14，3： | 4 |
| 6 | High-performance all-polymer solar cells enabled by a novel low bandgap non-fully conjugated polymer acceptor显示文摘The non-fully conjugated polymer as a new class of acceptor materials has shown some advantages over its small molecular counterpart when used in photoactive layers for all-polymer solar cells(all-PSCs),despite a low power conversion efficiency(PCE)caused by its narrow absorption spectra.Herein,a novel non-fully conjugated polymer acceptor PFY-2TS with a low bandgap of~1.40 eV was developed,via polymerizing a largeπ-fused small molecule acceptor(SMA)building block(namely YBO)with a non-conjugated thioalkyl linkage.Compared with its precursor YBO,PFY-2TS retains a similar low bandgap but a higher LUMO level.Moreover,compared with the structural analog of YBO-based fully conjugated polymer acceptor PFY-DTC,PFY-2TS shows a similar absorption spectrum and electron mobility,but significantly different molecular crystallinity and aggregation properties,which results in optimal blend morphology with a polymer donor PBDB-T and physical processes of the device in all-PSCs.As a result,PFY-2TS-based all-PSCs achieved a PCE of 12.31%with a small energy loss of 0.56 eV enabled by the reduced non-radiative energy loss(0.24 eV),which is better than that of 11.08%for the PFY-DTC-based ones.Our work clearly demonstrated that non-fully conjugated polymers as a new class of acceptor materials are very promising for the development of high-performance all-PSCs. | Qunping Fan Ruijie Ma Tao Liu Jianwei Yu Yiqun Xiao Wenyan Su Guilong Cai Yuxiang Li Wenhong Peng Tao Guo Zhenghui Luo Huiliang Sun Lintao Hou Weiguo Zhu Xinhui Lu Feng Gao Ellen Moons Donghong Yu He Yan Ergang Wang | 2021 | Science China Chemistry2021，64，8： | 3 |
| 7 | Origin of the springtime South China Sea Warm Current in the southwestern Taiwan Strait: Evidence from seawater oxygen isotope显示文摘Oxygen isotope(δ^18O)of seawater is an excellent proxy for tracing the origins of water masses and their mixing processes.Combining with hydrographic observation,hybrid coordinate ocean model(HYCOM)analysis data,and seawater oxygen isotope,we investigated the source of the South China Sea Warm Current(SCSWC)in the southwestern Taiwan Strait and its underlying mechanism.Results show that the Kuroshio subsurface water(KSSW)can intrude the continental slope in the southwestern Taiwan Strait,and thereby climb up the continental slope coupled with upwelling.Theδ^18O-salinity relationship further indicates that in spring,the SCSWC in the southwestern Taiwan Strait originates from the upslope deflection of the slope current formed by the KSSW intrusion into the South China Sea,rather than from the west segment of the SCSWC formed to the east of Hainan Island.In addition,the southward flowing Zhe-Min Coastal Current(ZMCC)can reach as far as the Taiwan Bank(TB)and deflects offshore over the western TB at approximately 23.5°N,to some extent affecting the SCSWC.Moreover,this study reveals that seawaterδ^18O is exquisitely sensitive to the determination of the origin and transport of water masses as compared with traditional potential temperature-salinity plot(θ-S)and HYCOM analysis data.In addition,their coupling can more reliably interpret the mixing processes of shelf water masses. | Dongyu CHEN Ergang LIAN Yeqiang SHU Shouye YANG Yalong LI Chao LI Pengfei LIU Ni SU | 2020 | Science China Earth Sciences2020，63，10： | 2 |
| 8 | Donor polymers containing benzothiadiazole and four thiophene rings in their repeating units with improved photovoltaic performance 显示文摘 | Wang Ergang Wang Ming Wang Li | 2009 | Macromolecules2009，42，13： | 1 |
| 9 | Local metabo- lism of glucocorticoids and its role in rat adjuvant arthritis 显示文摘 | ERGANG P LEDEN P VAGNEROVA K | 2010 | Mol Cell Endocrinol2010，323，2： | 1 |
| 10 | Local metabolism of glucocorticoids and its role in rat adjuvant arthritis显示文摘 | Ergang P Leden P Vagnerovd K | 2010 | Mo[ Cell Endocrinol2010，12，323： | 1 |
| 11 | Synthesis and rate performance of monolithic macroporous carbon electrodes for lithium-ion secondary batteries 显示文摘 | K T Lee J C L N S Ergang S M Oh A Stein | 2005 | Advanced Functional Materials2005，15，4： | 1 |
| 12 | Lake-level records support a mid-Holocene maximum precipitation in northern China显示文摘Lake level and its inferred East Asian summer monsoon(EASM)evolution in northern boundary of EASM during the Holocene are highly debated.Here,we present a 15-ka record of glycerol dialkyl glycerol tetraethers(GDGTs)in a closed lake in northern China to address this issue.Surface and downcore sediment data demonstrate sedimentary GDGT-0 and branched GDGTs(brGDGTs)are of aquatic production.Contents of GDGT-0 and brGDGTs increase but brGDGT-based paleo-temperature proxy decreases with water depth in surface sediments along a nearshore to offshore transect.This trend is likely due to an increasingly hypoxic condition,favored by anaerobic microbes producing these GDGT-0 and brGDGTs,in bottom water.Accordingly,brGDGT-derived water temperature and pH would reflect bottom water conditions that are largely regulated by water depth of the lake.Downcore GDGT data and their derived temperature and pH consistently reveal a gradually increasing lake level from the late Pleistocene to the early Holocene,a high level during 9.5-5 ka BP and a decreasing trend afterward.The lake-level records from independent and robust proxies in this study largely agree with pollen records in the region,supporting a mid-Holocene maximum EASM precipitation. | Jiantao CAO Zhiguo RAO Fuxi SHI Ergang LIAN Guodong JIA | 2021 | Science China Earth Sciences2021，64，12： | 1 |
| 13 | Proteomic analysis of chicken eggshell cuticle membrane layer显示文摘 | Miksik I Ergang P Pacha J | 2014 | Analytical and Bioanalytical Chemistry2014，406，： | 1 |
| 14 | 查看详情显示文摘 | Wang Z Y Li F Ergang N S Stein A | | 0，，： | 1 |
| 15 | The Research on Design and Application of Interactive Micro-video Learning Resources ——Take the Course of Computer Application in Medicine for Example显示文摘 | Li Xiaowei Feng Weikai Xiao Ergang | 2014 | Journal of Zhouyi Research2014，，1： | 1 |
| 16 | 显示文摘 | Wang Z Y Ergang N S AI-Daous M A | 2005 | Chem Mater2005，17，26： | 1 |
| 17 | High-performa- nce polymer heterojunction solar ceils of a polysilafluorene derivative显示文摘 | Wang Ergang Wang Li Lan Linfeng | 2008 | Appl Phys Lett2008，92，03： | 1 |
| 18 | Side- chain architectures of 2, 7-earbazole and quinoxaline-based polymers for efficient polymer solar cells 显示文摘 | Wang Ergang Hou Lintao Wang Zhongqiang | 2011 | Macromole- cules2011，44，： | 1 |
| 19 | High-performance polymer heterojunction solar cells of a polysilafluorene derivative显示文摘 | Wang Ergang Wang Li Lan Linfeng | 2008 | Applied Physics Letters2008，92，03： | 1 |
| 20 | Effects of Flexible Conjugation-Break Spacers of Non-Conjugated Polymer Acceptors on Photovoltaic and Mechanical Properties of All-Polymer Solar Cells显示文摘All-polymer solar cells(all-PSCs)possess attractive merits including superior thermal stability and mechanical flexibility for large-area roll-to-roll processing.Introducing flexible conjugation-break spacers(FCBSs)into backbones of polymer donor(P_(D))or polymer acceptor(P_(A))has been demonstrated as an efficient approach to enhance both the photovoltaic(PV)and mechanical properties of the all-PSCs.However,length dependency of FCBS on certain all-PSC related properties has not been systematically explored.In this regard,we report a series of new non-conjugated P_(A)s by incorporating FCBS with various lengths(2,4,and 8 carbon atoms in thioalkyl segments).Unlike com-mon studies on so-called side-chain engineering,where longer side chains would lead to better solubility of those resulting polymers,in this work,we observe that the solubilities and the resulting photovoltaic/mechanical properties are optimized by a proper FCBS length(i.e.,C2)in P_(A) named PYTS-C2.Its all-PSC achieves a high efficiency of 11.37%,and excellent mechanical robustness with a crack onset strain of 12.39%,significantly superior to those of the other P_(A)s.These results firstly demonstrate the effects of FCBS lengths on the PV performance and mechanical properties of the all-PSCs,providing an effective strategy to fine-tune the structures of P_(A)s for highly efficient and mechanically robust PSCs. | Qiaonan Chen Yung Hee Han Leandro R.Franco Cleber F.N.Marchiori Zewdneh Genene CMoyses Araujo Jin-Woo Lee Tan Ngoc-Lan Phan Jingnan Wu Donghong Yu Dong Jun Kim Taek-Soo Kim Lintao Hou Bumjoon J.Kim Ergang Wang | 2022 | Nano-Micro Letters2022，14，10： | 1 |
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