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| 1 | 心理行为干预对乳腺癌患者情绪反应及免疫功能的影响显示文摘按随机和匹配原则 ,将 40名乳腺癌放疗患者分入干预组和对照组。对干预组患者进行为期 4周的心理行为干预 ,对照组仅接受相应的医药治疗。以肿瘤病人情绪适应问卷 (MAC)和免疫测试法研究患者干预前后的情绪反应和免疫功能 ,探讨心理行为干预对乳腺癌患者情绪反应和免疫功能的影响。结果发现 ,心理行为干预有利于提高患者NK细胞活性 (NKCA) ;并有助于维持放疗期间患者的白细胞水平。 | 刘艳 林文娟 刘新帆 张冀岗 Erika M Hardy Meg Mountainbear | 2001 | 心理学报2001，33，5： | 59 |
| 2 | 针刺太冲穴得气及疼痛激发相对抗的脑功能网络效应fMRI研究显示文摘目的:采用磁共振脑功能成像技术,比较针刺太冲穴得气及针刺疼痛时所激发的脑功能网络效应异同。方法:47例初次接受针刺的志愿者参加手针右侧太冲穴fMRI实验。针刺时脑fMRI扫描10min,共2次捻针,各2min,间隔3min。其中17例接受体表触觉刺激作为针刺对照,分为3组:①针刺得气组;②针刺得气合并尖锐性疼痛组(简称针刺疼痛组);③触觉对照组。采用Fisher’s精确检验和t检验分析感觉频率及强度;用AFNI处理fMRI数据,得到激活、负激活脑区;用种子相关分析法,以前扣带回膝部为种子点,分析其与全脑的功能网络联系图谱,并比较得气与疼痛组之间的差异。结果:针刺2组的酸痛、酸感、压感、麻感、钝痛等得气感觉的频率和强度均明显强于触觉刺激组;针刺2组间除尖锐性疼痛及酸痛外,各种感觉差异无统计学意义。针刺得气及疼痛2组均激活了体感及丘脑岛叶皮层,重要的是,针刺得气时在大脑边缘叶-旁边缘叶-新皮层系统(LPNN)产生了较强而广泛的负激活区,加强了负激活区之间的脑功能网络联系。此网络包括杏仁核、海马、旁海马、颞极、前额叶腹内侧回、前扣带回膝及下部、前楔叶内侧回和后扣带回(BA31,23_腹侧核,29,30),另外,小脑蚓部、导水管周围灰质及脑干网状结构也见负激活现象。然而,在针刺疼痛时,这些脑区负激活程度减低且区域缩小,大部分脑区fMRI信号逆转为激活信号,被疼痛激活的脑区之间功能网络明显增强。这些脑区参与了疼痛、镇痛(如感觉、情感、认知、自主性、内源性镇痛)功能调制环路。结合既往研究表明,负激活与脑血氧消耗及血流量下降呈正相关。本结果支持针刺通过调制LPNN和疼痛中枢网络的活动,产生其镇痛、抗焦虑和其他调节效应的假说。结论:针刺得气及针刺得气伴随疼痛产生了相对抗的脑功能网络效应。针刺得气对LPNN及疼痛脑中枢网络(Pain matrix)的负激活效应,可能与针刺镇痛脑中枢机制相关。LPNN和静息态默认网络(Default mode)之间的相似性,提示针刺需通过这一内在脑功能网络系统发挥其广泛的调制作用。 | 方继良 Hui KS Kathleen Liu Jing Nixon Erika 周科华 王小玲 朱兵 | 2012 | 中国中西医结合影像学杂志2012，10，1： | 52 |
| 3 | Beneficial effects of naringenin in liver diseases: Molecular mechanisms显示文摘Liver diseases are caused by different etiological agents, mainly alcohol consumption, viruses, drug intoxication or malnutrition. Frequently, liver diseases are initiated by oxidative stress and inflammation that lead to the excessive production of extracellular matrix(ECM), followed by a progression to fibrosis, cirrhosis and hepatocellular carcinoma(HCC). It has been reported that some natural products display hepatoprotective properties. Naringenin is a flavonoid with antioxidant, antifibrogenic, anti-inflammatory and anticancer properties that is capable of preventing liver damage caused by different agents. The main protective effects of naringenin in liver diseases are the inhibition of oxidative stress, transforming growth factor(TGF-β) pathway and the prevention of the transdifferentiation of hepatic stellate cells(HSC), leading to decreased collagen synthesis. Other effects include the inhibition of the mitogen activated protein kinase(MAPK), toll-like receptor(TLR) and TGF-β non-canonical pathways, the inhibition of which further results in a strong reduction in ECM synthesis and deposition. In addition, naringenin has shown beneficial effects on nonalcoholic fatty liver disease(NAFLD) through the regulation of lipid metabolism, modulating the synthesis and oxidation of lipids and cholesterol. Moreover, naringenin protects from HCC, since it inhibits growth factors such as TGF-β and vascular endothelial growth factor(VEGF), inducing apoptosis and regulating MAPK pathways. Naringenin is safe and acts by targeting multiple proteins. However, it possesses low bioavailability and high intestinal metabolism. In this regard, formulations, such as nanoparticles or liposomes, have been developed to improve naringenin bioavailability. We conclude that naringenin should be considered in the future as an important candidate in the treatment of different liver diseases. | Erika Hernández-Aquino Pablo Muriel | 2018 | World Journal of Gastroenterology2018，24，16： | 31 |
| 4 | Management of negative pressure wound therapy in the treatment of diabetic foot ulcers显示文摘Diabetic foot(DF) is a common complication of diabetes and the first cause of hospital admission in diabetic patients. In recent years several guidelines have been proposed to reinforce the the management of DF with a notable increase in diabetes knowledge and an overall reduction of amputations. Significant improvements have been reached in the treatment of diabetic foot ulcers(DFUs) and nowadays clinicians have several advanced medications to apply for the best local therapy. Among these, negative pressure wound therapy(NPWT) is a useful adjunct in the management of chronic and complex wounds to promote healing and wound bed preparation for surgical procedures such as skin grafts and flap surgery. NPWT has shown remarkable results although its mechanisms of action are not completely understood. In this paper, we offer a complete overview of this medication and its implication in the clinical setting. We have examined literature related to NPWT concerning human, animal and in vitro studies, and we have summarized why, when and how we can use NPWT to treat DFUs. Further we have associated our clinical experience to scientific evidence in the field of diabetic foot to identify a defined strategy that could guide clinician in the use of NPWT approaching to DFUs. | Marco Meloni Valentina Izzo Erika Vainieri Laura Giurato Valeria Ruotolo Luigi Uccioli | 2015 | World Journal of Orthopedics2015，6，4： | 33 |
| 5 | 发展生物燃料乙醇对我国区域农业发展的影响分析显示文摘本文利用“中国农业可持续发展决策支持系统”分析了不同燃料乙醇发展政策可能对我国农产品价格、整体和各区域农业生产及净产值等的影响。研究结果表明:燃料乙醇发展将显著提高能源作物的农产品价格,对农业发展和农民增收将起到积极的促进作用,但对稻谷和小麦等粮食安全有一些负面影响;燃料乙醇发展对不同区域及不同农户的影响有较大差异;多数地区的农业部门都将从中受益,获益的大小主要取决于各地区在种植能源作物上的比较优势。研究也指出,未来的重点应放在非粮作物以及第二代生物燃料乙醇技术上(即用纤维素生产乙醇),并且应该提高在这些方面的科研投资水平。 | 黄季焜 仇焕广 Michiel Keyzer Erika Meng Wim van Veen | 2009 | 经济学(季刊)2009，8，1： | 30 |
| 6 | Multidrug-resistant bacterial infections after liver transplantation: An ever-growing challenge显示文摘Bacterial infections are a leading cause of morbidity and mortality among solid organ transplant recipients.Over the last two decades,various multidrug-resistant(MDR)pathogens have emerged as relevant causes of infection in this population.Although this fact reflects the spread of MDR pathogens in health care facilities worldwide,several factors relating to the care of transplant donor candidates and recipients render these patients particularly prone to the acquisition of MDR bacteria and increase the likelihood of MDR infectious outbreaks in transplant units.The awareness of this high vulnerability of transplant recipients to infection leads to the more frequent use of broad-spectrum empiric antibiotic therapy,which further contributes to the selection of drug resistance.This vicious cycle is difficult to avoid and leads to a scenario of increased complexity and narrowed therapeutic options.Infection by MDR pathogens is more frequently associated with a failure to start appropriate empiric antimicrobial ther-apy.The lack of appropriate treatment may contribute to the high mortality occurring in transplant recipients with MDR infections.Furthermore,high therapeutic failure rates have been observed in patients infected with extensively-resistant pathogens,such as carbapenemresistant Enterobacteriaceae,for which optimal treatment remains undefined.In such a context,the careful implementation of preventive strategies is of utmost importance to minimize the negative impact that MDR infections may have on the outcome of liver transplant recipients.This article reviews the current literature regarding the incidence and outcome of MDR infections in liver transplant recipients,and summarizes current preventive and therapeutic recommendations. | Guilherme Santoro-Lopes Erika Ferraz de Gouvêa | 2014 | World Journal of Gastroenterology2014，20，20： | 24 |
| 7 | 法国旧石器技术研究概述显示文摘作为史前学和人类学的一个分支,史前石器技术研究从20世纪40年代开始在法国奠基,迄今形成以操作链为基础的比较完善的理论体系和研究方法。纵观60多年来法国代表性学者的理论与实践,以操作链概念为基础,到用剥坯和修型概念对前者加以完善,再到'操作型板'概念与技术-功能研究方法,法国旧石器技术研究经历了从初创、发展到深入三个研究阶段。结合中国旧石器时代考古学研究的历史与现状,本文对如何运用旧石器技术研究理论和方法也给予了简要探讨。 | 李英华 侯亚梅 Erika BODINL | 2008 | 人类学学报2008，27，1： | 23 |
| 8 | Helicobacter pylori virulence genes显示文摘Helicobacter pylori(H.pylori)is one of the most important human pathogens,infecting approximately half of the global population.Despite its high prevalence,only a subset of H.pylori infected individuals develop serious gastroduodenal pathology.The pathogenesis of H.pylori infection and disease outcome is thus thought to be mediated by an intricate interplay between host,environmental and bacterial virulence factors.H.pylori has adapted to the harsh milieu of the human stomach through possession of various virulence genes that enable survival of the bacteria in the acidic environment,movement towards the gastric epithelium,and attachment to gastric epithelial cells.These virulence factors enable successful colonization of the gastric mucosa and sustain persistent H.pylori infection,causing chronic inflammation and tissue damage,which may eventually lead to the development of peptic ulcers and gastric cancer.Numerous studies have focused on the prevalence and role of putative H.pylori virulence genes in disease pathogenesis.While several virulence factors with various functions have been identified,disease associations appear to be less evident,especially among different study populations.This review presents key findings on the most important H.pylori virulence genes,including several bacterial adhesins and toxins,in children and adults,and focuses on their prevalence,clinical significance and potential relationships. | Anja Sterbenc Erika Jarc Mario Poljak Matjaz Homan | 2019 | World Journal of Gastroenterology2019，25，33： | 19 |
| 9 | Specific probiotics alleviate allergic rhinitis during the birch pollen season显示文摘AIM:To investigate whether birch pollen allergy symptoms are linked with gut microbiota changes and whether probiotics have an effect on these.METHODS:Forty seven children with confirmed birch pollen allergy were randomized to receive either a probiotic combination of Lactobacillus acidophilus (L.acidophilus) NCFMTM (ATCC 700396) and Bifidobacterium lactis (B.lactis) Bl-04 (ATCC SD5219) or placebo in a double-blind manner for 4 mo,starting prior to onset of the birch pollen season.Symptoms were recorded in a diary.Blood samples were taken for analysis of cytokines and eosinophils.Fecal samples were analysed for microbiota components,calprotectin and IgA.Nasal swabs were taken for analysis of eosinophils.RESULTS:The pollen season induced a reduction in Bifidobacterium,Clostridium and Bacteroides which could not be prevented by the probiotic intervention.During the intervention,significantly higher numbers of B.lactis 11.2×107 ± 4.2×107 vs 0.1×107 ± 0.1×107 bacteria/g feces (P<0.0001) and L.acidophilus NCFMTM 3.5×106 ± 1.3×106 vs 0.2×106 ± 0.1×106 bacteria/g feces (P<0.0001) were observed in the probiotic group compared to the placebo group.During May,there was a tendency for fewer subjects,(76.2% vs 95.2%,P=0.078) to report runny nose,while during June,fewer subjects,11.1% vs 33.3%,reported nasal blocking in the probiotics group (P =0.101).Concomitantly,fewer subjects in the probiotic group had infiltration of eosinophils in the nasal mucosa compared to the placebo group,57.1% vs 95% (P=0.013).Eye symptoms tended to be slightly more frequent in the probiotic group,12.5 d [interquartile range (IQR) 6-18] vs 7.5 d (IQR 0-11.5) (P=0.066) during May.Fecal IgA was increased in the placebo group during the pollen season;this increase was prevented by the probiotics (P=0.028).CONCLUSION:Birch pollen allergy was shown to be associated with changes in fecal microbiota composition.The specific combination of probiotics used was shown to prevent the pollen-induced infiltration of eosinophils into the nasal mucosa,and indicated a trend for reduced nasal symptoms. | Arthur C Ouwehand Merja Nermes Maria Carmen Collado Nina Rautonen Seppo Salminen Erika Isolauri | 2009 | World Journal of Gastroenterology2009，15，26： | 19 |
| 10 | Genome and transcriptome analysis of the grapevine(Vitis vinifera L.) WRKY gene family显示文摘The plant WRKY gene family represents an ancient and complex class of zinc-finger transcription factors(TFs)that are involved in the regulation of various physiological processes,such as development and senescence,and in plant response to many biotic and abiotic stresses.Despite the growing number of studies on the genomic organisation of WRKY gene family in different species,little information is available about this family in grapevine(Vitis vinifera L.).In the present study,a total number of 59 putative grapevine WRKY transcription factors(VvWRKYs)were identified based on the analysis of various genomic and proteomic grapevine databases.According to their structural and phylogentic features,the identified grapevine WRKY transcription factors were classified into three main groups.In order to shed light into their regulatory roles in growth and development as well as in response to biotic and abiotic stress in grapevine,the VvWRKYs expression profiles were examined in publicly available microarray data.Bioinformatics analysis of these data revealed distinct temporal and spatial expression patterns of VvWRKYs in various tissues,organs and developmental stages,as well as in response to biotic and abiotic stresses.To also extend our analysis to situations not covered by the arrays and to validate our results,the expression profiles of selected VvWRKYs in response to drought stress,Erysiphe necator(powdery mildew)infection,and hormone treatments(salicilic acid and ethylene),were investigated by quantitative real-time reverse transcription PCR(qRT-PCR).The present study provides a foundation for further comparative genomics and functional studies of this important class of transcriptional regulators in grapevine. | Min Wang Alessandro Vannozzi Gang Wang Ying-Hai Liang Giovanni Battista Tornielli Sara Zenoni Erika Cavallini Mario Pezzotti Zong-Ming(Max)Cheng | 2014 | Horticulture Research2014，1，1： | 19 |
| 11 | Pneumatosis cystoides intestinalis following alpha-glucosidase inhibitor treatment:A case report and review of the literature显示文摘A 69-year-old man was diagnosed as having myasthenia gravis (MG) in September 2004,and treated with thymectomy and prednisolone. He was then diagnosed as having steroid-induced diabetes mellitus,and received sulfonylurea (SU) therapy in May 2005. An alpha-glucosidase inhibitor (αGI) was added in March 2006,resulting in good glycemic control. He experienced symptoms of abdominal distention,increased flatus,and constipation in October 2007,and was admitted into our hospital in late November with hematochezia. Plain abdominal radiography revealed small linear radiolucent clusters in the wall of the colon. Computed tomography (CT) showed intramural air in the sigmoid colon. Colonoscopy revealed multiple smooth surfaced hemispherical protrusions in the sigmoid colon. The diagnosis of pneumatosis cystoides intestinalis (PCI) was made on the basis of these findings. As the αGI voglibose was suspected as the cause of this patient's PCI,treatment was conservative,ceasing voglibose,with fasting and fluid supplementation. The patient progressed well,and was discharged 2 wk later. Recently,several reports of PCI associated with αGI therapy have been published,predominantly in Japan where αGIs are commonly used. If the use of αGIs becomes more widespread,we can expect more reports of this condition on a global scale. The possibility of PCI should be considered in diabetic patients complaining of gastrointestinal symptoms,and the gastrointestinal tract should be thoroughly investigated in these patients. | Tatsuhiro Tsujimoto Erika Shioyama Kei Moriya Hideto Kawaratani Yasuyo Shirai Masahisa Toyohara Akira Mitoro Jun-ichi Yamao Hisao Fujii Hiroshi Fukui | 2008 | World Journal of Gastroenterology2008，14，39： | 16 |
| 12 | 采用参与式方法研究农民关注的问题显示文摘本文提出了“采用参与式方法研究农民关注问题”的观点 ,通过大量的调查分析 ,对当前农民关注的问题进行了较为深入地剖析 ,并提出了解决问题的思路。 | 石晓华 胡瑞法 Erika Meng | 2003 | 农业经济问题2003，24，11： | 16 |
| 13 | 紫坪铺水库造成孔隙弹性耦合变化及其对2008年汶川地震触发作用显示文摘位于川西地区龙门山断裂带附近的紫坪铺水库于2005年9月开始蓄水.约2.7年后,2008年5月12日,Mw7.9级汶川地震在龙门山断裂带上发生,两事件在时间和空间上的接近,揭示其可能相互关联,但前人的诸多研究给出了不同甚至是相反的结果.本研究基于完全耦合孔隙弹性理论,利用二维有限元模型(FEM),模拟水库蓄水造成的区域孔隙压力场和应力场的演化过程,基于库仑应力演化探讨其对龙门山断裂带活动的影响.模拟结果显示紫坪铺水库蓄水打破了原来的区域孔隙压力平衡,形成孔隙压力梯度源,向周围地壳传播;进而造成龙门山断裂带上库仑应力正值范围不断扩大,由浅入深影响到整条断层,尤其对浅层范围的加载作用明显,达上百千帕,为整个断层面的失稳提供了基础.震源区域库仑应力呈持续增长趋势,汶川地震发震前,增长了约数千帕-数十千帕,即使初期库仑应力为负,在未来某时刻库仑应力仍可能由负转正,并不断增大.通过计算汶川地震震源及其附近区域内相对于多种可能断层倾角的库仑应力,发现库仑应力随断层倾角增大而增加.因此整体来看,紫坪铺水库蓄水对龙门山断裂带起加载作用,有可能触发地震.对紫坪铺库区周围的小震分析也显示,蓄水以来小震明显增多、且不同时段小震发生密集区与水库距离逐渐增大,与孔隙压力扩散趋势一致.以上结果表明紫坪铺水库的蓄水增加了汶川地震的危险性. | 陶玮 Timothy Masterlark 沈正康 Erika Ronchin 张永 | 2014 | 地球物理学报2014，57，10： | 13 |
| 14 | 多重劣化机制作用下混凝土的性能和耐久性(英文)显示文摘基于近年来芬兰VT技术研究中心在混凝土性能和耐久性方面的研究成果,对多重劣化机制共同作用下混凝土耐久性能表现进行了综述。这些研究是建立在30余年来有关混凝土耐久性的研究结果之上,包括15年的现场暴露实验数据,有关混凝土耐久性能是通过实验室加速实验结果和现场暴露实验结果共同评价的。结果显示,实验室的单一因素作用下的混凝土耐久性加速劣化结果与多因素共同作用下的暴露实验和工程现场测试结果有很大的差异。现场测试能够获得较长期的混凝土耐久性结果,这可以用来校准和验证混凝土耐久性和寿命预测模型,并引导继续对多因素共同作用下混凝土的耐久性能进行更全面深入的研究。 | Erika HOLT Miguel FERREIRA Hannele KUOSA Markku LEIVO | 2015 | 硅酸盐学报2015，43，10： | 13 |
| 15 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 16 | Role of non-steroidal anti-inflammatory drugs on intestinal permeability and nonalcoholic fatty liver disease显示文摘The use of non-steroidal anti-inflammatory drugs(NSAIDs) is widespread worldwide thanks to their analgesic, anti-inflammatory and antipyretic effects. However, even more attention is placed upon the recurrence of digestive system complications in the course of their use. Recent data suggests that the complications of the lower gastro-intestinal tract may be as frequent and severe as those of the upper tract. NSAIDs enteropathy is due to enterohepatic recycling of the drugs resulting in a prolonged and repeated exposure of the intestinal mucosa to the compound and its metabolites. Thus leading to so-called topical effects, which, in turn, lead to an impairment of the intestinal barrier. This process determines bacterial translocation and toxic substances of intestinal origin in the portal circulation, leading to an endotoxaemia. This condition could determine a liver inflammatory response and might promote the development of nonalcoholic steatohepatitis, mostly in patients with risk factors such as obesity, metabolic syndrome and a high fat diet, which may induce a small intestinal bacterial overgrowth and dysbiosis. This alteration of gut microbiota may contribute to nonalcoholic fatty liver disease and its related disorders in two ways: firstly causing a malfunction of the tight junctions that play a critical role in the increase of intestinal permeability, and then secondly leading to the development of insulin resistance, body weight gain, lipogenesis, fibrogenesis and hepatic oxidative stress. | erika utzeri paolo usai | 2017 | World Journal of Gastroenterology2017，23，22： | 12 |
| 17 | 手针针刺合谷穴得气和疼痛相反的脑边缘叶效应fMRI研究1例显示文摘受试者,男,36岁,身体健康,参加手针针刺右侧合谷穴fMRI试验。
试验1:首先在右侧合谷穴体表实施触觉刺激作为针刺对照实验,采用标准5.88mm塑料细纤维(von Frey纤维,美国Stoeling公司生产),均匀柔和手动刺激穴位,频率60次/min,fMRI扫描和刺激间隔模式与针刺组相同。刺激后无明显疼痛及酸麻胀重感觉。试验2:针刺右侧合谷穴,完成扫描后,告知针刺只感觉到尖锐性疼痛,但能忍受,无酸麻胀重感觉。 | 方继良 Hui KS Kathleen Liu Jing Nixon Erika 周科华 王小玲 | 2012 | 中国中西医结合影像学杂志2012，10，2： | 12 |
| 18 | Curcumin and Apigenin – novel and promising therapeutics against chronic neuroinflammation in Alzheimer's disease显示文摘Alzheimer's disease is a progressive neurodegenerative disorder, characterized by deposition of amyloid beta, neurofibrillary tangles, astrogliosis and microgliosis, leading to neuronal dysfunction and loss in the brain. Current treatments for Alzheimer's disease primarily focus on enhancement of cholinergic transmission. However, these treatments are only symptomatic, and no disease-modifying drug is available for Alzheimer's disease patients. This review will provide an overview of the proven antioxidant, anti-inflammatory, anti-amyloidogenic, neuroprotective, and cognition-enhancing effects of curcumin and apigenin and discuss the potential of these compounds for Alzheimer's disease prevention and treatment. We suggest that these compounds might delay the onset of Alzheimer's disease or slow down its progression, and they should enter clinical trials as soon as possible. | Madhuri Venigalla Erika Gyengesi Gerald Münch | 2015 | Neural Regeneration Research2015，10，8： | 11 |
| 19 | Genetic, metabolic and environmental factors involved in the development of liver cirrhosis in Mexico显示文摘Liver cirrhosis(LC) is a chronic illness caused by inflammatory responses and progressive fibrosis. Globally, the most common causes of chronic liver disease include persistent alcohol abuse, followed by viral hepatitis infections and nonalcoholic fatty liver disease. However, regardless of the etiological factors, the susceptibility and degree of liver damage may be influenced by genetic polymorphisms that are associated with distinct ethnic and cultural backgrounds. Consequently, metabolic genes are influenced by variable environmental lifestyle factors, such as diet, physical inactivity, and emotional stress, which are associated with regional differences among populations. This Topic Highlight will focus on the genetic and environmental factors that may influence the metabolism of alcohol and nutrients in the setting of distinct etiologies of liver disease. The interaction between genes and environment in the current-day admixed population, Mestizo and Native Mexican, will be described. Additionally, genes involved in immune regulation, insulin sensitivity, oxidative stress and extracellular matrix deposition may modulate the degree of severity. In conclusion, LC is a complex disease. The onset, progression, and clinical outcome of LC among the Mexican population are influenced by specific genetic and environmental factors. Among these are an admixed genome with a heterogenic distribution of European, Amerindian and African ancestry; a high score of alcohol consumption; viral infections; a hepatopathogenic diet; and a high prevalence of obesity. The variance in risk factors among populations suggests that intervention strategies directed towards the prevention and management of LC should be tailored according to such population-based features. | Omar Ramos-Lopez Erika Martinez-Lopez Sonia Roman Nora A Fierro Arturo Panduro | 2015 | World Journal of Gastroenterology2015，21，41： | 11 |
| 20 | 日本新型冠状病毒肺炎传播初期阶段的流行现状及应对显示文摘新型冠状病毒肺炎(COVID-19)于2019年12月开始出现病例报道以来,逐渐在全球范围内传播。日本国内的COVID-19病例从2020年1月中旬开始出现,并随时间推移持续增加,至2020年2月底前被认为是日本国内传播的初期阶段。本文描述截至2020年2月底与日本有关的935例COVID-19病例的传播状况,包括从武汉包机接回的15例日本侨民感染者、大型邮轮“钻石公主”号中的696例感染者以及日本国内的224例感染者状况。同时总结了日本控制疫情扩散的措施,如限制针对新型冠状病毒(SARS-CoV-2)进行RT-PCR检测、降低不必要的前往医疗机构就诊的轻症患者人数、制订SARS-CoV-2感染咨询的准则、取消大型聚会、暂时关闭学校等。进一步提出了日本在预防与控制SARS-CoV-2传播中遇到的问题,如RT-PCR的检测迟缓、医务人员面临被感染风险、日本国内医疗保健服务体系存在地区差异、信息公开与管理存在混乱等。通过以上介绍,加深对COVID-19在日本及全球流行特点的理解,为全球控制COVID-19疫情提供借鉴。 | 王继伟 谷本哲也 赵天辰 津田健司 山下Erika 上昌广 姜庆五 | 2020 | 上海预防医学2020，32，4： | 10 |
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