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| 1 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 2 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 3 | Mensenchymal progenitor cells in human umbilical cord blood 显示文摘 | Erices A Conget P Minguell JJ | 2000 | Br J Haematol2000，109，： | 2 |
| 4 | Mesenchymal stem cells显示文摘 | Minguell JJ Erices A Conger P | 2001 | Exp Biol Med2001，226，6： | 1 |
| 5 | Mesenchymal stem cells显示文摘 | Minguell JJ Erices A Conget P | 2001 | Exp Biol Med2001，226，6： | 1 |
| 6 | Mesenchymal progenitor cells in human umbilical cord blood 显示文摘 | Erices A Conget P Minguell JJ | 2000 | Br J Haematol2000，109，： | 1 |
| 7 | Mesenchymal progenitor cells in human umbilical cord blood显示文摘 | Erices A Conget P Minguell JJ | 2000 | Br J Haematol2000，109，1： | 1 |
| 8 | Mesenchymal stem cells显示文摘 | Minguell JJ Erices A Conget P | 2001 | Exp Biol Med(Maywod)2001，226，6： | 1 |
| 9 | Mesenchymal stem cells显示文摘 | Minguell JJ Erices A Conget P | | 0，，： | 1 |
| 10 | Mesenchymal stem cells 显示文摘 | Minguell JJ Erices A Conget P | 2003 | Hum Ce112003，16，1： | 1 |
| 11 | Mesenchymal progenitors cell in human umbilical cord blood显示文摘 | Erices A Conget P Mingull JJ | 2000 | Br J Haematol2000，109，： | 1 |
| 12 | Mesenchymal stem cells and the treatment of cardiac disease显示文摘 | Minguell JJ Erices A | 2006 | Experimental Biology and Medicine2006，231，： | 1 |
| 13 | The Association between Ciga- rette Smoking and Risk of Colorectal Cancer in a Large Prospective Cohort from the United States 显示文摘 | Lindsay MH Eric JJ Michael JT | 2009 | Cancer Epidemiol Biomarkers Prey2009，18，12： | 1 |
| 14 | Mesenchymal progenitor cells in human umbilical cord blood显示文摘 | Conget P Minguell JJ | 2000 | Br J Haematol2000，109，1： | 1 |
| 15 | Mesenchymal progenitor cells in human umbilical cord blood 显示文摘 | Erices A Conget P Minguell JJ | 2000 | Br J Haematol2000，109，1： | 1 |
| 16 | Mesenchymal stem cells显示文摘 | Minguell JJ Erices A Conger P | 2001 | Exp Biol Med2001，226，6： | 1 |
| 17 | Mesenchymal stem cells显示文摘 | Minguell JJ Erices A Conget P | 2001 | Exp Biol Med2001，226，6： | 1 |
| 18 | Mesenchymal progenitor cells in human umbilical cord blood显示文摘 | Erices A Conget P Minguell JJ | 2000 | Br J Haematol2000，109，1： | 1 |
| 19 | Mesenchymal stem cells显示文摘 | Minguell JJ Erices A Conget p | 2001 | Exp BiolMed2001，226，6： | 1 |
| 20 | Mesenchymal stem cells显示文摘 | Minguell JJ Erices A Conget P | 2001 | Exp Biol Med2001，226，： | 1 |
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