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| 1 | Impact of alcohol on hepatitis C virus replication and interferon signaling显示文摘Hepatitis C virus (HCV) is one of the main etiological factors responsible for liver disease worldwide. It has been estimated that there are over 170 million people infected with HCV worldwide. Of these infected individuals, approximately 75% will go on to develop a life long necroinflammatory liver disease, which over decades, can result in serious complications, such as cirrhosis and hepatocellular carcinoma. Currently there is no effective vaccine and whilst antiviral therapies have been improved, they are still only effective in approximately 50% of individuals. HCV infection stands as a major cause of global morbidity and suffering, and places a signifi cant burden on health systems. The second highest cause of liver disease in the western world is alcoholic liver disease. Frequently, HCV infected individuals consume alcohol, and the combined effect of HCV and alcohol consumption is deleterious for both liver disease and response to treatment. This review discusses the impact of alcohol metabolism on HCV replication and the negative impact on interferon (IFN)-α treatment, with a particular focus on how alcohol and HCV act synergistically to increase oxidative stress, ultimately leading to exacerbated liver disease and a reduction in the effi cacy of IFN-α treatment. A better understanding of the complicated mechanisms at play in hepatocytes infected with HCV and metabo- lizing alcohol will hopefully provide better treatment options for chronic hepatitis C individuals that consume alcohol. | Erin M McCartney Michael R Beard | 2010 | World Journal of Gastroenterology2010，16，11： | 5 |
| 2 | Prognostic impact of the Bismuth-Corlette classification:Higher rates of local unresectability in stageⅢb hilar cholangiocarcinoma显示文摘Background:The Bismuth-Corlette(BC)classification is used to categorize hilar cholangiocarcinoma by proximal extension along the biliary tree.As the right hepatic artery crosses just behind the left bile duct,we hypothesized that BCⅢb tumors would have a higher likelihood of local unresectability due to involvement of the contralateral artery.Methods:A retrospective review of a prospectively maintained database identified patients with hilar cholangiocarcinoma taken to the operating room for intended curative resection between April 2008 and September 2016.Cases were assigned BC stages based on preoperative imaging.Results:Sixty-eight patients were included in the study.All underwent staging laparoscopy after which 16 cases were aborted for metastatic disease.Of the remaining 52 cases,14 cases were explored and aborted for locally advanced disease.Thirty-eight underwent attempt at curative resection.After exclud-ing cases aborted for metastatic disease,the chance of proceeding with resection was 55.6%for BCⅢb staged lesions compared to 80.0%of BCⅢa lesions and to 82.4%for BCⅠ-Ⅲa staged lesions(P<0.05).About 44.4%of BCⅢb lesions were aborted for locally advanced disease versus 17.6%of remaining BC stages.Conclusions:When hilar cholangiocarcinoma is preoperatively staged as BCⅢb,surgeons should antici-pate higher rates of locally unresectable disease,likely involving the right hepatic artery. | Michael J Passeri Maria R Baimas-George Jesse K Sulzer David A Iannitti John B Martinie Erin H Baker Lee M Ocuin Dionisios Vrochides | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，2： | 3 |
| 3 | High-resolution Z-contrast STEM of Guinier-Preston zones in Al-3% Ag 显示文摘 | Erin R Heinrieh H Kostorz G | 2003 | Materials Chemistry and Physics2003，81，： | 1 |
| 4 | Phylogenetic diversity of gram-positive bacteria cultured form marine sediment 显示文摘 | Erin A G William F Paul R J | 2007 | Appl Environ Microbiol2007，73，10： | 1 |
| 5 | Carboncapture and storage using alkaline industrial wastes显示文摘 | Bobicki Erin R Qingxia Liu Zhenghe Xu | 2012 | Progress in Energy and Combustion Science2012，，38： | 1 |
| 6 | Effect of age on the tuning of the cVEMP and oVEMP显示文摘 | PIKE R ERIN G | 2013 | Ear Hearing2013，34，： | 1 |
| 7 | Rapid screening of environmental chemicals for estrogen receptor binding capacity显示文摘 | Bolqer R Wiese TE Erin K | 1998 | Environ Health Perspect1998，106，9： | 1 |
| 8 | In vitro hypoxia and excitotoxicity in human brain induce calclneurin-Bcl-2 interactions 显示文摘 | Erin N Lehman R A Boyer P J Billingsley M L | 2003 | Neuroscience2003，117，3： | 1 |
| 9 | In vitro hypoxia and excitotoxicity in human brain induce calclneurin-bcl-2 interactions显示文摘 | ERIN N LEHMAN R A BOYER P J | | 0，，03： | 1 |
| 10 | Cosily Search and Mutual Fund Flows显示文摘 | SIRRI ERIN R TUFANO PETER | 1998 | The Journal of Finance1998，53，5： | 1 |
| 11 | Triclosan in waste and surface waters from the upper Detroit River by liquid chromatography-electrospray-tandem quadrupole mass spectrometry显示文摘 | HUA Wenyi ERIN R B ROBERT J L | 2005 | Environmental International2005，31，5： | 1 |
| 12 | A comparison of human immunodeficiency virus,hepatitis C virus,hepatitis B virus,and human Tlymphotropic virus marker rates for directed versus volunteer blood donations to the American Red Cross during 2005 to 2010显示文摘 | Kerri A Erin D Whitney R | | 0，，6： | 1 |
| 13 | Multiplex Lateral-Flow Test Strips Fabricated by Two-Dimensional Shaping 显示文摘 | Erin M F Monica R M Gabriel P L | 2009 | Applied Materials and Interfaces2009，1，1： | 1 |
| 14 | Transforming sustainable food and waste be- haviors by realigning domains of knowledge in our educationsys- tem显示文摘 | Erin R Aaron R | 2014 | Journal of Cleaner Production2014，64，2： | 1 |
| 15 | Current strategies in the diag nosis and treatment of childhood attention-deficit/hyperac tivity disorder 显示文摘 | Robert R Larry M Erin CC | 2009 | American Family Physician2009，79，8： | 1 |
| 16 | Costly search and mutual fund flows显示文摘 | Sirri Erin R Tufano Peter | 1998 | The Journal of Finance1998，53，5： | 1 |
| 17 | Application of self-organizing feature maps to analyze the rela- tionships between ignitable liquids and selected mass spectral ions 显示文摘 | Jessica L Frisch- Daiello Mary R Williams Erin E Waddell | 2014 | Forensic Science International2014，236，： | 1 |
| 18 | The central role of metal coordination in selenium antioxidant activity显示文摘 | Battin Erin E Pert'on Nathan R Brumaghim Julia L | 2006 | Inorg Chem2006，45，2： | 1 |
| 19 | Culturable marine actinomycete diversity from tropical Pacific Ocean sediments显示文摘 | Paul R J Erin G Chrisy M | 2005 | Environ Microbiol2005，7，7： | 1 |
| 20 | Climatie and geornorphic in- teractions on alluvial fans in the Atacama Desert, Chile显示文摘 | Erik W H Erin R K Jacob O S | 2010 | Geo- morphology2010，121，： | 1 |
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