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| 1 | 内源性大麻素系统在神经病理性疼痛临床治疗中应用显示文摘1.神经病理性疼痛的治疗现状神经病理性疼痛是严重影响人类生活质量的一种慢性疾病,然而当前针对神经病理性疼痛的治疗效果依然不尽如人意。因此,针对神经病理性疼痛新的治疗策略的研究是当前的重中之重。2.内源性大麻素系统内源性大麻素系统在疼痛调控中起着关键作用。它是由大麻素受体、相应的内源性配体以及与之相关的酶组成。目前已发现2种大麻素受体, | Maldonado R Ba?os JE Caba?ero D 孙武平 | 2016 | 中国疼痛医学杂志2016，22，11： | 2 |
| 2 | Delayed postoperative latent pain sensitization revealed by the systemic administration of opioid antagonists in mice显示文摘 | CAMPILLO A CABAERO D ROMERO A | 2011 | Eur J Pharmacol2011，2，13： | 1 |
| 3 | Complications of endoscopic microdiscectomy using the EASYGO ! system: is there any differencewith conventional discectomy during the learning-curve period?显示文摘 | Martín-Láez R Martínez-Agüeros JA Su6rez-Femández D | 2012 | Acta Neurochir (Wien)2012，154，6： | 1 |
| 4 | Measurement of corneal curvature change after mechanical laser in situ keratomileusis flap creation and femtosecond laser flap creation显示文摘 | Ortiz D Alió JL Pi(n)ero D | | 0，，： | 1 |
| 5 | KOH and NaOH activation mechanisms of multiwalled carbon nanotubes with different structural organization显示文摘 | Raymundo-Pi(n)ero E Aza(i)s P Cacciaguerra T Cazorla-Amorós D Linares-Solano A Béguin F | | 0，，04： | 1 |
| 6 | Headspace volatile components of smoked swordfish (Xiphias gladius) and cod (Gadus morhua) detected by means of solid phase microextraction and gas chromatography-mass spectrometry显示文摘 | Guille'n M D Errecalde M C Salm ero'n J | 2006 | Food Chemistry2006，，94： | 1 |
| 7 | Pronoeiceptive effects of remifentanil in a mouse model of postsurgleal pain: effect of a second surgery显示文摘 | Caba ero D Campillo A Celerier E | 2009 | Anesthesiology2009，111，6： | 1 |
| 8 | Corneal incision quality:microincision cataract surgery versus microcoaxial phacoemulsification显示文摘 | ElkadyB Pi(n)ero D Alió JL | | 0，，： | 1 |
| 9 | Fluorodeoxyglueose positron emission tomography in semantic dementia after 6 months of memantine: an open-label pilot study 显示文摘 | Chow TW Fam D Graff-Guen'ero A | 2013 | Int J Geriatr Psychiatry2013，28，： | 1 |
| 10 | Factors controling the SO 2 removal by porous carbons: relevance of the SO 2 oxidation step显示文摘 | E Raymundo-Pi?ero D Cazorla-Amorós C Salinas-Martinez de Lecea A Linares-Solano | 2000 | Carbon2000，，3： | 1 |
| 11 | Corneal incision quality:microincision cataract surgery versus microcoaxial phacoemulsification显示文摘 | Elkady B Pi(n)ero D Alió JL | | 0，，03： | 1 |
| 12 | Clinicopathological differences,risk factors and prognostic scores for western patients with intestinal and diffuse-type gastric cancer显示文摘BACKGROUND In the molecular era,the Laurén system is still a cost-effective and widely implemented classification for gastric cancer(GC)and it has been recently associated with clinical,histological and molecular features of these tumors.Despite recent advances in the understanding of the molecular biology of GC,there is a need to develop new prognostic tools for patient stratification in clinical practice.Thus,the identification of easily available prognostic factors in patients with intestinal and diffuse-type tumors can significantly improve risk assessment and patient stratification in GC.AIM To identify clinicopathological differences,risk factors,and to develop costeffective prognostic scores for patients with intestinal and diffuse-type GC.METHODS Retrospective study of all patients undergoing surgery for GC at a tertiary referral center from 2001 to 2019.286 cases met inclusion criteria(intestinal:190,diffuse:96).Clinical data and gross findings were collected.All specimens were reviewed by two independent pathologists and a detailed protocol for histologic evaluation was followed.Five tissue microarrays(TMAs)were constructed and sections of the TMA block were immunostained for HERCEPTEST,MSH2,MSH6,MLH1 and PMS2.Statistical analyses were performed and prognostic scores were developed based on hazard ratios.RESULTS Intestinal and diffuse-type GC showed different epidemiological,clinicopathological and prognostic features.Diffuse tumors were significantly associated with younger age,less symptomatology,flat morphology,deeper invasion,perineural infiltration,advanced stage at diagnosis,administration of adjuvant therapy and poorer prognosis.Intestinal lesions were fungoid or polypoid,showed necrosis,desmoplasia,microsatellite instability and HERCEPTEST positivity and were diagnosed at earlier stages.Tumor depth,desmoplasia,macroscopic type and lymph node involvement were independently related to the Laurén subtype.Furthermore,intestinal and diffuse GC were associated with different risk factors for progression and death.Vascular invasion,perineural infiltration and growth pattern were important prognostic factors in intestinal-type GC.On the contrary,tumor size and necrosis were significant prognosticators in diffuse-type GC.Our recurrence and cancer-specific death scores for patients with intestinal and diffuse-type GC showed an excellent patient stratification into three(diffuse GC)or four(intestinal)prognostic groups.CONCLUSION Our findings support that Laurén subtypes represent different clinicopathological and biological entities.The development of specific prognostic scores is a useful and cost-effective strategy to improve risk assessment in GC. | Cristina Díaz del Arco Lourdes Estrada Muñoz Luis Ortega Medina Elena Molina Roldán MÁngeles Cerón Nieto Soledad García Gómez de las Heras M Jesús Fernández Aceñero | 2022 | World Journal of Gastrointestinal Oncology2022，14，6： | 1 |
| 13 | Effects of within-patch habitat structure and variation on fish assemblage characteristics in the Bernecei stream, Hungary 显示文摘 | EROS T GROSSMAN G D | 2005 | Ecology of Freshwater Fish2005，14，25： | 1 |
| 14 | Loss of E-cadherin expression in melanoma ceils involves up-regulation of the transcriptional repressor Snail 显示文摘 | Poser I Dominguez D de Hen'eros AG | 2001 | J Biol Chem2001，276，24： | 1 |
| 15 | Mathematical programming models for supply chain production and transport planning显示文摘 | Mula J Peidro D Díaz-Madro?ero M | 2010 | European Journal of Operational Research2010，204，3： | 1 |
| 16 | Addressing uncertainties in the ERICA integrated approach显示文摘 | OUGHTON D H AGERO A AVILA R | 2008 | J Environ Radioact2008，99，： | 1 |
| 17 | Corneal biomechanical properties in normal,post-laser in situ keratomileusis,and keratoconic eyes显示文摘 | Ortiz D Pi(n)ero D Shabayek MH | 2007 | J Cataract Refract Surg2007，33，： | 1 |
| 18 | Effect of arbuscular mycorrhizal fungi and rhizobacteria on banana growth and nutrition显示文摘 | Rodr(I)guez-Romero A S Pi(n)ero Guerra M S Carmen JaizmeVega M D | 2005 | Agron Sustain Dev2005，25，： | 1 |
| 19 | Tyrosinase from Rhizobium etli is involved in nodulation efficiency and symbiosis-associated stress resistance显示文摘 | Pi(n)ero S Rivera J Romero D | | 0，，1： | 1 |
| 20 | Structural characterization of N-containing activated carbon fibers prepared from a low softening point petroleum pitch and a melamine resin显示文摘 | E Raymundo-Pi?ero D Cazorla-Amorós A Linares-Solano J Find U Wild R Schl?gl | 2002 | Carbon2002，，4： | 1 |
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