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| 1 | Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer显示文摘The Tribbles(TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2 nd International Symposium on Tribbles and Diseases held on May 7–9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases. | Bing Cui Patrick A. Eyers Leonard L. Dobens Nguan Soon Tan Peter D. Mace Wolfgang A. Link Endre Kiss-Toth Karen Keeshan Takuro Nakamura Warren S. Pear Yodit Feseha Jessica Johnston Arkatiz Carracedo Marcel Scheideler Zabran llyas Robert C. Bauer Jorge D. Erusalimsky Dominika Grzesik Juan Salamanca-Viloria Xiaoxi Lv Yishi Jin Ke Li Guillermo Velasco Shuang Shang Jose M. Lizcano Xiaowei Zhang Jichao Zhou Jiaojiao Yu Fang Hua Feng Wang Shanshan Liu Jinmei Yu Zhuowei Hu | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 2 |
| 2 | Basic Fibroblast Growth Factor Upregulates the Expression of Vascular Endothelial Growth Factor in Vascular Smooth Muscle Cells: Synergistic Interaction With Hypoxia显示文摘 | George T. Stavri Ian C. Zachary Paul A. Baskerville John F. Martin Jorge D. Erusalimsky | 1995 | Circulation1995，，1： | 1 |
| 3 | Does nitric oxide modulate mitochondrial energy generation and apoptosis? 显示文摘 | Moncada S Erusalimsky J D | 2002 | Nat Rev Mol Cell Biol2002，3，3： | 1 |
| 4 | Nitric oxide and mitochondrial signaling: from physiology to pathophysiology 显示文摘 | Erusalimsky JD Moncada S | 2007 | Arterioscler Thromb Vasc Bi- ol2007，27，： | 1 |
| 5 | Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo显示文摘 | Debacq-Chainiaux F Erusalimsky JD Campisi J | 2009 | Nat Protoc2009，4，12： | 1 |
| 6 | Nitric oxide and mitochondrial signaling: from physiology to pathophysiology 显示文摘 | Erusalimsky JD Moncada S | 2007 | Arterioscler Thromb Vasc Biol2007，27，12： | 1 |
| 7 | Protocols to detect senescence-associated beta-galactosidase(SA-betagal) activity, a biomarker of senescent cells in culture and in vivo显示文摘 | Debacq-Chainiaux F Erusalimsky JD Campisi J | 2009 | Nat Protoc2009，4，12： | 1 |
| 8 | Does nitric oxide modulate mitochondrial energy generation and apoptosis? 显示文摘 | MONCADA S ERUSALIMSKY JD | 2002 | Nat Rev Mol Cell Biol2002，3，3： | 1 |
| 9 | Vascular endothelial senes- cence: from mechanisms to pathophysiology 显示文摘 | Erusalimsky JD | 2009 | J Appl Physiol2009，106，1： | 1 |
| 10 | Does nitric oxide modulate mitochondrial energy generation and apoptosis显示文摘 | Moncada S Erusalimsky JD | | 0，，： | 1 |
| 11 | Does nitric oxide modulate mitochondrial energy generation and apoptosis? 显示文摘 | Moncada S Erusalimsky JD | 2002 | Nat Rev Mol Cell Biol2002，3，3： | 1 |
| 12 | Does nitric oxide modulate mitochon- drial energy generation and apoptosis? 显示文摘 | Moneada S Erusalimsky JD | 2002 | Nat Rev Mol Cell Biol2002，3，3： | 1 |
| 13 | Does nitric oxide modulate mitochondrial energy generation and apoptosis? 显示文摘 | Moncada S Erusalimsky JD | 2002 | Nat Rev Mol Cell Biol2002，3，： | 1 |
| 14 | Endothelial cell senescence显示文摘 | Kurz DJ | 2006 | Handb Exp Pharmacol2006，，1762： | 1 |
| 15 | Protocols to detect senescence-associated beta-galactosidase (SA-betagal)activity, a biomarker of senescent cells in cul- ture and in vivo 显示文摘 | Debacq-Chainiaux F Erusalimsky J D Campisi J | 2009 | Nat Protoc2009，4，12： | 1 |
| 16 | Cellular senescence in vivo: its relevance in ageing and cardiovascular disease 显示文摘 | Erusalimsky JD Kurz DJ | 2005 | Exp Gerontol2005，40，89： | 1 |
| 17 | Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo 显示文摘 | Debacq CF Erusalimsky JD Campisi J | 2009 | Nat Protoc2009，4，12： | 1 |
| 18 | Evidence against the involvement of nitric oxide in the modulation of telomerase activity or replicative capacity of human endothelial cells显示文摘 | Hong Y Quintero M Frakich NM Trivier E Erusalimsky JD | 2007 | Exp Gerontol2007，42，9： | 1 |
| 19 | Mechanisms of endothelial senescence显示文摘 | Erusalimsky JD Skene C | 2009 | Exp Physiol2009，94，： | 1 |
| 20 | Does nitric oxide modulate mitochondrial energy generation and apoptosis?显示文摘 | MONCADA S ERUSALIMSKY J D | 2002 | Nat Rev Mol Cell Biol2002，3，： | 1 |
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