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| 1 | Cigarette smoke-induced cell cycle arrest in spermatocytes [GC-2spd(ts)] is mediated through crosstalk between Ahr–Nrf2 pathway and MAPK signaling显示文摘Our earlier studies have demonstrated that the cigarette smoke in the form of cigarette smoke condensate(CSC)causes growth arrest of a mouse spermatocyte cell line[GC-2spd(ts)]through activation of the AHR–NRF2 pathway.The present study demonstrates the CSC-activated p38 and ERK MAPK signaling in GC-2spd(ts)via arylhydrocarbon receptor(AHR).Pharmacological inhibition by using AHR-antagonist,or p38 MAPK and ERK(MEK1)inhibitors significantly abrogates CSC-induced growth arrest by AHR and MAPK inactivation.QRT-PCR,western blot,and immunofluorescence of Ahr-target of Nrf2,and stress-inducible growth suppressive Atf3 and E2f4 following treatments indicate a crosstalk among these pathways.Regulation of Atf3 by Nrf2 and Ahr through RNA interference suggests the existence of a cross-regulatory loop between the targets.CSC induction of E2f4 via Atf3 and its regulation by pharmacological inhibitors reveal a possible regulatory mechanism of growth inhibitory CSC.SiRNA silencing of Ahr,Nrf2,Atf3,and E2f4 genes and downregulation of cyclins by CSC corroborate the growth inhibitory effect of cigarette smoke.Thus,the data obtained suggest that the CSC-mediated MAPKs and AHR–NRF2 crosstalks lay the molecular basis for the growth arrest and cell death of spermatocytes. | Prabagaran Esakky Deborah A.Hansen Andrea M.Drury Kelle H.Moley | 2015 | Journal of Molecular Cell Biology2015，7，1： | 1 |
| 2 | Intestinal bacterial diversity in five rocklobster Panulirus homarus (Linnaeus)(Decapoda,Pleocyemata,Palinuridae) during transportation process显示文摘 | Grasian Immanuel Palanisamy lyappa Raj Palanichamy Esakki Raj | 2006 | Pan-American joumal of aquatic sciences2006，1，2： | 1 |
| 3 | Intestinal bacterial diversity in live rock lobster Pamulirus homorus (Linnaeus) (Decapoda Pleocyemata,Palinuridae) during transportation process显示文摘 | Palanisamy lyappa Raj Palanichamy Esakki Raj | 2006 | Pan-American journal of aquatic sciences2006，1，2： | 1 |
| 4 | Effects of side-stream, low temperature phosphorus recovery on the performance of anaerobic/anoxic/oxic systems integrated with sludge pretreatment显示文摘 | S. Esakki Raj J. Rajesh Banu S. Kaliappan Ick-Tae Yeom S. Adish Kumar | 2013 | Bioresource Technology2013，，： | 1 |
| 5 | Nature:寨卡病毒导致小鼠睾丸体积缩小、结构破坏显示文摘大部分针对寨卡病毒(Zika Virus)的研究发现。寨卡病毒感染的影响主要集中在孕妇和出生缺陷。但在小鼠中。新的研究发现了寨卡病毒对于小鼠雄性生殖系统的严重损伤,引起了人们对人类男性可能遭受得到的威胁的严重关切。美国华盛顿大学医学院的研究人员们,通过在《Nature》上的研究文章,报道了寨卡病毒对于雄性小鼠的生殖系统的损害。 | Jennifer Govero, Justin M. Richner, Elizabeth A. Caine, Vanessa Salazar Michael S. Diamond Prabagaran Esakky, Suzanne M. Scheaffer, Andrea Drury Kelle H. Moley Estefania Fernandez, Matthew J. Gorman Michael S. Diamond Derek J. Platt Michael S. Diamond Kelle H. Moley Michael S. Diamond | 2017 | 现代生物医学进展2017，17，6： | 0 |
| 6 | Parallelization of H.264 Encoder Using FPGA Based Symmetric Multi-Core Processors显示文摘 | Murali Krishnan Elumalai Gangadharan Esakki Nirmal Kumar | 2011 | 通讯和计算机(中英文版)2011，8，6： | 0 |
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