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| 1 | Potential mechanisms of hepatitis B virus induced liver injury显示文摘Chronic active hepatitis(CAH) is acknowledged as an imperative risk factor for the development of liver injury and hepatocellular carcinoma.The histological end points of CAH are chronic inflammation,fibrosis and cirrhosis which are coupled with increased DNA synthesis in cirrhotic vs healthy normal livers.The potential mechanism involved in CAH includes a combination of processes leading to liver cell necrosis,inflammation and cytokine production and liver scaring(fibrosis).The severity of liver damage is regulated by Hepatitis B virus genotypes and viral components.The viral and cellular factors that contribute to liver injury are discussed in this article.Liver injury caused by the viral infection affects many cellular processes such as cell signaling,apoptosis,transcription,DNA repair which in turn induce radical effects on cell survival,growth,transformation and maintenance.The consequence of such perturbations is resulted in the alteration of bile secretion,gluconeogenesis,glycolysis,detoxification and metabolism of carbohydrates,proteins,fat and balance of nutrients.The identification and elucidation of the molecular pathways perturbed by the viral proteins are important in order to design effective strategy to minimize and/or restore the hepatocytes injury. | Mohd Suhail Hany Abdel-Hafiz Ashraf Ali Kaneez Fatima Ghazi A Damanhouri Esam Azhar Adeel GA Chaudhary Ishtiaq Qadri | 2014 | World Journal of Gastroenterology2014，20，35： | 12 |
| 2 | Role of relevant immune-modulators and cytokines in hepatocellular carcinoma and premalignant hepatic lesions显示文摘AIM To assess the levels of different immune modulators in patients with hepatocellular carcinoma(HCC),in relation to other hepatic diseases.METHODS Eighty-eight patients were included in the current study and represented patients with HCC(20),liver cirrhosis(28) and chronic hepatitis(CH;25),and normal controls(NC;15).Peripheral blood was isolated for immunophenotyping of active myeloid dendritic cells(m DCs;CD1 c and CD40),mature inactive myeloid cells(CD1 c and HLA),active plasmacytoid cells(p DCs;CD303 and CD40),mature inactive p DCs(CD30 and HLA),active natural killer(NK) cells(CD56 and CD161),active NK cells(CD56 and CD314) and inactive NK cells(CD56 and CD158) was done by flow cytometry.Serum levels of interleukin(IL)-2,IL-10,IL-12,IL-1β,interferon(IFN)-α,IFN-γ and tumor necrosis factor(TNF)-αR2 were assessed by ELISA.RESULTS Active m DCs(CD1 C+/CD40+) and inactive m DCs(CD1 c+/HLA+) were significantly decreased in HCC patients in relation to NC(P < 0.001).CD40+ expression on active p DCs was decreased in HCC patients(P < 0.001),and its level was not significantly changed among other groups.Inactive p DCs(CD303+/HLA+),inactive NKs(CD56+/CD158+) and active NKs(CD56+/CD161+) were not statistically changed among the four groups studied;however,the latter was increased in CH(P < 0.05).NKG2 D was statistically decreased in HCC,CH and cirrhosis(P < 0.001),and it was not expressed in 63%(12/20) of HCC patients.There was significant decrease of IL-2,IFN-α and IFN-γ(P < 0.001),and a significant increase in IL-10,IL-1β,and TNF-αR2(P <0.01,P < 0.001 and P < 0.001;respectively) in HCC patients.There was inverted correlation between IL-12 and IL-1β in HCC(r =-0.565,P < 0.01),with a strong correlation between p DCs(CD303+/CD40+) and NKs(CD56+/CD161+;r = 0.512,P < 0.05) as well as inactive m DCs(CD1 c+/HLA+) and inactive NK cells(CD56+/CD158+;r = 0.945,P < 0.001).CONCLUSION NKG2 D,CD40,IL-2 and IL-10 are important modulators in the development and progression of HCC. | Abdel-Rahman N Zekri Somaya El Deeb Abeer A Bahnassy Abeer M Badr Mona S Abdellateif Gamal Esmat Hosny Salama Marwa Mohanad Ahmed Esam El-dien Shimaa Rabah Assmaa Abd Elkader | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 3 | Illumination InvariantFeature Extraction and Mutual--Information-based LocalMatching for Face Recognition Under Illumination Variation andOcclusion显示文摘 | Nabatchian A Esam A R Ahmadi M | 2011 | Pattern Recognition2011，44，10： | 1 |
| 4 | The role of periodic vortex shedding in heat transfer enhancement for transient pulsatile flow inside wavy channels显示文摘 | ESAM M A RAED I B | 2008 | Proceedings of World Academy of Science Engineering & Technology2008，，22： | 1 |
| 5 | Effect of lead acetate toxicity on experimental male albino rat显示文摘Objective:To evaluate the effect of different doses of lead acetate(1/20,1/40 and 1/60 of LD_(50))on body weight gain,blood picture,plasma prolein profile and the function of liver,kidney and thyroid gland.Methods:Male albino rats were divided into four groups,the first group represented the health control animals,while the second,third and fourth groups were ingested orally with sub lethal doses of load acetate(1/20,1/40 and 1/60)of the oral LD_(50),respectively.One dose was ingested every two days during the experimental period(14 weeks)including the adaptation time.Blood was collected and used for all analysis.Results:The results showed that,the ingestion of Pb^(2+)induced significant stimulation in glutamic-pyruvic transaminase(ALT)and glutamic-oxalacetic transaminease(AST)activity.Also,total soluble protein and albumin contents of plasma were significantly decreased,while the content of globulin was changed by the Pb^(2+)treatments.The cholinesteiase activity was inhibited,but the activities of alkaline and acid phosphates and lactate dehydrogenase were stimulated,while plasma glucose level was elevated as a result of lead acetate intoxication.In case of blood picture,Pb^(2+)ingestion reduced the contents of hemoglobin and RBCs count of intoxicated rat's blood and the plasma levels of T3,T4 and blood WBCs count were decreased.Conclusions:It can be concluded that lead acetate has harmful effect on experimental male albino rats.Therefore,the present work advises people to prevent exposure to the lead compound to avoid injurious hazard risk. | Nabil M Ibrahim Esam A Eweis Hossam S El-Beltagi Yasmin E Abdel-Mobdy | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，1： | 1 |
| 6 | Modified inference about the mean of the exponential distribution using moving extreme ranked set sampling显示文摘 | Walid A D Esam A S | | 0，，： | 1 |
| 7 | What factors affect intra- partum maternal temperature? A prospective cohort study: mater- nal intrapartum temperature 显示文摘 | Fr61ich MA Esame A Zhang K | 2012 | Anesthesiology2012，117，2： | 1 |
| 8 | Thermal analysis of a building brick containing phase change material显示文摘 | Esam M A | 2007 | Energy and Buildings2007，40，3： | 1 |
| 9 | A family of single switch PWM converters with high step-up conversion ratio显示文摘 | Esam H Ismail Mustafa A A1-Saffar Ahmad Asbzali | 2008 | IEEE Transactions on Gir- cuits and System2008，55，4： | 1 |
| 10 | In-situ detection of single particles of explosive on clothing with confocal Raman microscopy 显示文摘 | Esam M A A Howell G M E Ian J S | 2009 | Talanta2009，78，3： | 1 |
| 11 | Raman spectroscopy and security applications: the de- tection of explosives and precursors on clothing 显示文摘 | Esam M A Ali Howell G M Edwards Ian J Scowen | 2009 | J Raman Spectrosc2009，2014，： | 1 |
| 12 | The influence of increased per- itoneal membrane surface area on dialysis adequacy 显示文摘 | Alhwiesh A Esam S Saeed I | | Saudi J Kidney Dis Transpl0，22，4： | 1 |
| 13 | Fast Variable Block Size Motion Estimation by Adaptive Early Termination 显示文摘 | ESAM A Al QARALLEH TIAN -SHEUAN CHANG | 2006 | IEEE transactions on circuits and systems for video technology2006，16，8： | 1 |
| 14 | What factors affect intrapartum maternal temperature? A prospective cohort study : maternal intrapartum temperature 显示文摘 | Fr~lich MA Esame A Zhang K | 2012 | Anesthesiol- ogy2012，117，2： | 1 |
| 15 | New bridgeless DCM sepic and cuk PFC rectifiers with low con- duction and switching losses 显示文摘 | AHMAD J Sabzali ESAM H Ismail MUSTAFA A AI-Saffar | 2011 | IEEE Transactions on Power E- lectronics2011，47，2： | 1 |
| 16 | Fast variable block size rao-lion estimation by adaptive early termination 显示文摘 | Esam A A Qaralleh Chang T S | 2006 | IEEE Trans-actions on Circuits Systems for Video Technology2006，16，8： | 1 |
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