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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice显示文摘 | ESCANDE C CHINI C C NIN V | 2010 | J Clin Invest2010，120，2： | 1 |
| 3 | Role of deleted in breast cancer 1(DBC1)protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase显示文摘 | Nin V Escande C Chini CC | 2012 | J Biol Chem2012，287，23： | 1 |
| 4 | Metabolic profiles of sunflower genotypes with contrasting response to Sclerotinia sclerotiorum infection显示文摘 | Peluffo L Lia V Troglia C Maringolo C Norma P Escande A Esteban Hopp H Lytovchenko A Fernie A R Heinz R Carrari F | 2010 | Phytochemistry2010，71，1： | 1 |
| 5 | Flavonoid apigenin is an inhib- itor of the NAD + ase CD38 : implications for cellular NAD + me- tabolism, protein acetylation, and treatment of metabolic syndrome 显示文摘 | Escande C Nin V Price NL | 2013 | Diabetes2013，62，4： | 1 |
| 6 | HDAC3 is negatively regulatedby the nuclear protein DBC1 显示文摘 | Chini CC Escande C Nin V | 2010 | J Biol Chem2010，285，40： | 1 |
| 7 | In vitro polyploidization of Mecardonia tenella,a native plant from South America显示文摘 | ESCAND(O)N A S ALDERETE L M HAGIWARA J C | 2007 | Scientia Horticulturae2007，115，： | 1 |
| 8 | Deleted in breast cancer-1regulates SIRT1 activity and contributes to high-fat diet 一 in-duced liver steatosis in mice 显示文摘 | Escande C Chini CC Nin V | 2010 | J Clin Invest2010，120，2： | 1 |
| 9 | Histological features and management of a mandibular Gorham disease:a case report and review of maxillofacial cases in the literature显示文摘 | Escande C Schouman T Francoise G | 2008 | Oral Surg Oral Med Oral Palhol Oral Radiol Endod2008，106，3： | 1 |
| 10 | Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP- activated protein kinase显示文摘 | Nin V Escande C Chini C C | 2012 | J Biol Chem2012，287，23： | 1 |
| 11 | Regulation of Sirtl-mediated NAD-dependent deacetylation: a novel role for the multifunctional enzyme CD38显示文摘 | Aksoy P Escande C White TA | 2006 | Biochem Biophys Res Commun2006，349，： | 1 |
| 12 | Histological fea- tures and management of a mandibular Gorham disease: a case report and review of maxillofacial cases in the literature显示文摘 | Escande C Schouman T Franoise G | 2005 | Oral Surg Oral Med Oral Pathol Oral Radio1 Endod2005，106，3： | 1 |
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