4篇
您的检索式：作者名="Esteban Ballestar"
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| 1 | A DNA methylation signature associated with aberrant promoter DNA hypermethylation of DNMT3B in human colorectal cancer显示文摘 | Covadonga Huidobro Rocío G. Urdinguio Ramón María Rodríguez Cristina Mangas Vincenzo Calvanese Pablo Martínez-Camblor Cecilia Ferrero Adolfo Parra-Blanco Luis Rodrigo álvaro J. Obaya Laura Suárez-Fernández Aurora Astudillo Henar Hernando Esteban Ballestar | 2011 | European Journal of Cancer2011，，14： | 1 |
| 2 | Genetic unmasking of an epigenetically silenced micro-RNA in human cancer cells显示文摘 | Amaia Lujambio Santiago Ropero Esteban Ballestar | 2007 | Cancer Res2007，67，： | 1 |
| 3 | Notch Signaling Is Essential for Ventricular Chamber Development显示文摘 | Joaquín Grego-Bessa Luis Luna-Zurita Gonzalo del Monte Victoria Bolós Pedro Melgar Alejandro Arandilla Alistair N. Garratt Heesuk Zang Yoh-suke Mukouyama Hanying Chen Weinian Shou Esteban Ballestar Manel Esteller Ana Rojas José María Pérez-Pomares José Lu | 2007 | Developmental Cell2007，，： | 1 |
| 4 | Epigenetic regulation of B cells and its role in autoimmune pathogenesis显示文摘B cells play a pivotal role in the pathogenesis of autoimmune diseases.Although previous studies have shown many genetic polymorphisms associated with B-cell activation in patients with various autoimmune disorders,progress in epigenetic research has revealed new mechanisms leading to B-cell hyperactivation.Epigenetic mechanisms,including those involving histone modifications,DNA methylation,and noncoding RNAs,regulate B-cell responses,and their dysregulation can contribute to the pathogenesis of autoimmune diseases.Patients with autoimmune diseases show epigenetic alterations that lead to the initiation and perpetuation of autoimmune inflammation.Moreover,many clinical and animal model studies have shown the promising potential of epigenetic therapies for patients.In this review,we present an up-to-date overview of epigenetic mechanisms with a focus on their roles in regulating functional B-cell subsets.Furthermore,we discuss epigenetic dysregulation in B cells and highlight its contribution to the development of autoimmune diseases.Based on clinical and preclinical evidence,we discuss novel epigenetic biomarkers and therapies for patients with autoimmune disorders. | Fan Xiao Ke Rui Xiaofei Shi Haijing Wu Xiaoyan Cai Kathy O.Lui Qianjin Lu Esteban Ballestar Jie Tian Hejian Zou Liwei Lu | 2022 | Cellular & Molecular Immunology2022，19，11： | 0 |
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