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| 1 | Current status of laparoscopic and robotic ventral mesh rectopexy for external and internal rectal prolapse显示文摘External and internal rectal prolapse with their affiliated rectocele and enterocele, are associated with debilitating symptoms such as obstructed defecation, pelvic pain and faecal incontinence. Since perineal procedures are associated with a higher recurrence rate, an abdominal approach is commonly preferred. Despite the description of greater than three hundred different procedures, thus far no clear superiority of one surgical technique has been demonstrated. Ventral mesh rectopexy(VMR) is a relatively new and promising technique to correct rectal prolapse. In contrast to the abdominal procedures of past decades, VMR avoids posterolateral rectal mobilisation and thereby minimizes the risk of postoperative constipation. Because of a perceived acceptable recurrence rate, good functional results and low mesh-related morbidity in the short to medium term, VMR has been popularized in the past decade. Laparoscopic or robotic-assisted VMR is now being progressively performed internationally and several articles and guidelines propose the procedure as the treatment of choice for rectal prolapse. In this article, an outline of the current status of laparoscopic and robotic ventral mesh rectopexy for the treatment of internal and external rectal prolapse is presented. | Jan J van Iersel Tim JC Paulides Paul M Verheijen John W Lumley Ivo AMJ Broeders Esther CJ Consten | 2016 | World Journal of Gastroenterology2016，22，21： | 20 |
| 2 | Attenuation of dextran sodium sulphate induced colitis in matrix metalloproteinase-9 deficient mice显示文摘AIM: To study whether matrix metalloproteinase-9 (MMP-9) is a key factor in epithelial damage in the dextran sodium sulphate (DSS) model of colitis in mice.METHODS: MMP-9-deficient and wild-type (wt) mice were given 5% DSS in drinking water for 5 d followed by recovery up to 7 d. On d 5 and 12 after induction of colitis, gelatinases, MMP-2 and MMP-9, were measured in homogenates of colonic tissue by zymography and Western blot, whereas tissue inhibitor of metalloproteinases (TIMPs) were measured by reverse zymography. The gelatinolytic activity was also determined in supernatants of polymorphonuclear leukocytes (PMN) isolated from mice blood. Moreover, intestinal epithelial cells were stimulated with TNF-α to study whether these cells were able to produce MMPs. Finally, colonic mucosal lesions were measured by microscopic examination. RESULTS: On d 5 of colitis, the activity of MMP-9 was increased in homogenates of colonic tissues (0.24 ± 0.1 vs 21.3 ± 6.4, P < 0.05) and PMN from peripheral blood in wt (0.5 ± 0.1 vs 10.4 ± 0.7, P < 0.05), but not in MMP-9-deficient animals. The MMP-9 activity was also up-regulated by TNF-α in epithelial intestinal cells (2.5 ± 0.5 vs 14.7 ± 3.0, P < 0.05). Although colitis also led to increase of TIMP-1 activity, the MMP-9/TIMP-1 balance remained elevated. Finally, in the MMP-9-deficient colitic mice both the extent and severity of intestinal epithelialinjury were significantly attenuated when compared with wt mice. CONCLUSION: We conclude that DSS induced colitis is markedly attenuated in animals lacking MMP-9. This suggests that intestinal injury induced by DSS is modu-lated by MMP-9 and that inhibition of this gelatinase may reduce inflammation. | Alfredo Santana Carlos Medina Maria Cristina Paz-Cabrera Federico Díaz-Gonzalez Esther Farré Antonio Salas Marek W Radomski Enrique Quintero | 2006 | World Journal of Gastroenterology2006，12，40： | 9 |
| 3 | Public participation in integrated water resources management:the case of Tanzania显示文摘 | ESTHER W D NDALAHWA F M | 2003 | Physics and Chemistry of the Earth Parts A/B/C2003，28，2027： | 1 |
| 4 | Behavior in children with language development disorders显示文摘 | Ulrike W Esther B Gabriele DR | 2003 | Can J Psychiatry2003，48，9： | 1 |
| 5 | Public participation in integrated water resources management: the case of Tanzania 显示文摘 | Esther W Dungumaro Ndalahwa F Madulu | 2003 | Physics and Chemistry of the Earth2003，28，： | 1 |
| 6 | Vitamins C and E improve regrowth and reduce lipid peroxidation of blackberry shoot tips following cryopreservation 显示文摘 | Esther E U Scott W L Maret G T | 2010 | Plant Cell Reports2010，29，1： | 1 |
| 7 | Silk Fibroin as a Vehicle forDrug Delivery Applications 显示文摘 | Esther W Hans P M Lorenz M | 2011 | J Control Release2011，150，： | 1 |
| 8 | Inhibition of tumor growth by poly(ethylene glycol) derivatives of anti-ErbB2 antibodies显示文摘 | ESTHER H LEAH N K MEIR W | 2000 | Cancer Immunol Immunother2000，49，： | 1 |
| 9 | Decomposition of transgenic Bacillus thuringiensis maize by microorganisms and woodlice Porcellio scaber (Crustacea: Isopoda)显示文摘 | Esther N Kach B Nentwig W | 2000 | Basic Applied Ecology2000，1，： | 1 |
| 10 | Influence of clarithromycin on early atherosclerotic lesions after chlamydia pneumoniae infection in a rabbit model显示文摘 | Ignatius W Fong BC Esther V | 2002 | Antimicrobial Agents and Chemotherapy2002，46，8： | 1 |
| 11 | Examining native and exotic species diversity in European riparian forests显示文摘 | Annik S Brack W H Esther M A | 2007 | Biological Conservation2007，138，： | 1 |
| 12 | Patient-doctorinteraction,psychobehavioural characteristics and mentaldisorders in patients with suspected allergies: do they predict'medically unexplained symptoms'?显示文摘 | Constanze H W’Martine G Esther B | 2011 | Acta dermato-venereologica}2011，91，： | 1 |
| 13 | Insulin-like growth factor- Ⅰ and Ⅱ in the ovary of a bony fish, Oreochromis mossambicus, the tilapia: in situ hybridiaztion,immunohistochemical localization, Northern blot and cDNA sequences 显示文摘 | SCHMID A C ESTHER N KLOAE W | 1999 | Molecular and celluar Endocrinology1999，156，12： | 1 |
| 14 | Is the Development Control Legal Framework Conducive to a Sustainable Dense Urban Development in Hong Kong?显示文摘 | Chan Edwin H W Yung Esther H K | 2004 | Habitat International2004，28，3： | 1 |
| 15 | Humeral Shaft Fractures: measuring Recovery after operative versus Non-operative Treatment 显示文摘 | Kiran C Mahabier Esther MM Van Lieshout Hugo W Bolhuis | 2014 | BMC Musculoskeletal Disorders2014，，15： | 1 |
| 16 | Silk fibroin as a vehicle for drug delivery applications显示文摘 | Esther W Hans P M Lorenz M | 2011 | J Control Release2011，150，2： | 1 |
| 17 | The impacts of product modularity on competitive capabilities and performance: An empirical study 显示文摘 | Lau Antonio K W Richard C M Yam Esther Tang | 2007 | International Journal of Production Economics2007，，1： | 1 |
| 18 | Changes in tissue free amino acid contents, branchial Na/K-ATPase activity and bimodal breathing pattern in the fresh water climbing perch, Anabas testudineus (Bloch), during seawater acclimation 显示文摘 | Esther W C Ai M L Wai P W | 2007 | Experimental Zoology2007，307，12： | 1 |
| 19 | Policy making on data exclusivity in the European Union: from industrial interests to legal realities显示文摘 | Adamini Sandra Maarse Hans Versluis Esther Light Donald W | 2009 | Journal of health politics policy and law2009，34，6： | 1 |
| 20 | Impact of early childhood adversities on adult psychiatric disorders:A study of international adoptees显示文摘 | ESTHER J M VAN DER VEGT TIEMAN W | 2009 | Soc Psychiatry Psychiatr Epidemiol2009，44，： | 1 |
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