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| 1 | Expression and Chromosomal Mapping of Mouse Gpx2 Gene Encoding the Gastrointestinal Form of Glutathione Peroxidase, GPX-GI显示文摘GPX-GI is a cytosolic tetrameric Se-dependent glutathione peroxidase, similar in properties to GPX-1. Unlike the almost ubiquitous GPX-1, GPX-GI is mainly expressed in the epithelium of gastrointestinal tract. GPX-GI contributes to at least fifty percent of GPX activity in rodent small intestmal epithelium. The total GPX activity consists of at least 70% of selenium-dependent GPX activity in this compartment.By analyzing a panel of mouse mterspecies DNA from the Jackson Laboratory’s backcross resource,we mapped Gpx2 gene to mouse chromosome 12 between D12Mit4 and D12Mit5, near the Ccs1 locus which contains a colon cancer susceptibility gene. A pseudogene, Gpx2-ps is mapped to mouse chromosome 7.Comparison of Gpx2 gene expression in three pairs of C57BL/6Ha and ICR/Ha mice which are respectively resistant and sensitive to dimethylhydrazine-induced colon cancer, we found a higher Gpx2 mRNA level in C57BL/6Ha colon than ICR/Ha colon. Interestingly, a lower level of GPX activity is found in the resistant strain of mice. Because GPX-1 has three times higher specific activity than GPX GI, our data suggest that the decreased GPX activity may result from a higher level of Gpx2 gene expression in those cells co-express GPx1 | FONG-FONG CHU R. STEVEN ESWORTHY YE SHIH HO MARGIT BERMEISTER KRISTINE SWIDEREK AND ROSEMARY W. ELLIOTT(Department of Medical Oncology, City of Hope Midical Center, Duarte,CA91010, USA Department of Psychiatry and Human Genetics,Mintal Health Research | 1997 | Biomedical and Environmental Sciences1997，10，2： | 5 |
| 2 | A novel near-infrared light responsive 4D printed nanoarchitecture with dynamically and remotely controllable transformation显示文摘Four-dimensional (4D) printing is an emerging and highly innovative additive manufacturing process by which to fabricate pre-designed,self-assembly structures with the ability to transform over time.However,one of the critical challenges of 4D printing is the lack of advanced 4D printing systems that not only meet all the essential requirements of shape change but also possess smart,dynamic capabilities to spatiotemporally and instantly control the shape-transformation process.Here,we present a facile 4D printing platform which incorporates nanomaterials into the conventional stimuli-responsive polymer,allowing the 4D printed object to achieve a dynamic and remote controlled,on-time and position shape transformation.A proof-of-concept 4D printed brain model was created using near-infrared light (NIR) responsive nanocomposite to evaluate the capacity for controllable 4D transformation,and the feasibility of photothermal stimulation for modulating neural stem cell behaviors.This novel 4D printing strategy can not only be used to create dynamic 3D patterned biological structures that can spatiotemporally control their shapes or behaviors of transformation under a human benign stimulus (NIR),but can also provide a potential method for building complex self-morphing objects for widespread applications. | Haitao Cui Shida Miao Timothy Esworthy Se-jun Lee Xuan Zhou Sung Yun Hann Thomas J.Webster Brent T.Harris Lijie Grace Zhang | 2019 | Nano Research2019，12，6： | 3 |
| 3 | Expression, char- acterization,and tissue distribution of a new cellular selenium - dependent glutathione peroxidase, GSHPx - GI 显示文摘 | Chu F F Doroshow J Esworthy R | 1993 | Journal of Biological Chemistry1993，268，4： | 1 |
| 4 | Role of Se dependent glutat hoine peroxidases in gastrointestinal inflammation and cancer显示文摘 | Cchuff Esworthys Doroshow J H | 2004 | Free Radical Biology and Medicine2004，36，12： | 1 |
| 5 | Glutathione peroxidase protects mice from viral-induced myocarditis 显示文摘 | Beck M A Esworthy R S Ho Y S | 1998 | FASEB J1998，12，： | 1 |
| 6 | Glutathione peroxidase protects mice form viral-induced myocarditis显示文摘 | Beck MA Esworthy RS Ho Y-S | 1998 | FASEB J1998，12，： | 1 |
| 7 | Bacteria-induced intestinalcancer in mice with disrupted GPX1 and GPX2 genes 显示文摘 | Chu FF Esworthy S Chu PG | 2003 | CancerRes2003，35，1： | 1 |
| 8 | Colitis locus on chromosome 2 impacting the severity of early-onset disease in mice deficient in GPX1 and GPX2显示文摘 | Esworthy RS Kim BW Larson GP | 2011 | Inflamm Bowel Dis2011，17，6： | 1 |
| 9 | Role of se- dependent glutathione peroxidases in gastrointestinal inflam- mation and cancer显示文摘 | CHU F F ESWORTHY R S DOROSHOW J H | 2004 | Free Radieal Biology & Medieine2004，36，12： | 1 |
| 10 | Bacteris-induced intestinal cancer in mice with disrupted Gpxl and GPx- gene显示文摘 | Chu FF Esworthy RS Cbu PG | 2004 | Cancer Res2004，64，3： | 1 |
| 11 | Expression, characterization, and tissue distribution of a new cellu- lar selenium-dependent glutathione peroxidase, GSH PxGI显示文摘 | Chu F F Doroshow J H Esworthy R S | 1993 | BiolChem1993，268，4： | 1 |
| 12 | Glutathione peroxidase protects mice from viral-induced myocarditis显示文摘 | Beck MA Esworthy RS Ho YS | 1998 | FBSEB J1998，12，12： | 1 |
| 13 | Modulation of glutathione peroxidase expression by selenium: effect on human MCF-7 breast cancer cell transfec rants expressing a cellular glutathione peroxidase cDNA and doxorubicin-resistant MCF-7cells显示文摘 | CHU FF ESWORTHY RS AKMAN S | 1990 | Nucleic Acids Res1990，18，： | 1 |
| 14 | Bacteria-induced intestinal cancer in mice with disrupted Gpxl and Gpx2 genes显示文摘 | CHU F F ESWORTHY R S CHU P G | 2004 | Cancer Res2004，64，3： | 1 |
| 15 | Mice with combined disruption of Gpxl and Gpx2 genes have colitis显示文摘 | ESWORTHY R S ARANDA R MARTIN M G | 2001 | Am J Physiol Gastrointest Liver Physiol2001，281，3： | 1 |
| 16 | Role of Se-dependent glutathoine peroxidases in gastrointestinal inflammation and cancer显示文摘 | CCHU F F ESWORTHY R S DOROSHOW J H | 2004 | Free Radical Biology and Medicine2004，36，12： | 1 |
| 17 | Role of Se-dependent glutathione peroxidases in gastrointestinal inflammation and cancer显示文摘 | CHU FF ESWORTHY RS DOROSHOW JH | 2004 | Free Radic Biol Med2004，，36： | 1 |
| 18 | Colitis lo- cus on chromosome 2 impacting the severity of early-onset disease in mice deficient in GPX1 and GPX2显示文摘 | ESWORTHY RS KIM BW LARSON GP | 2011 | Inflamm Bowel Dis2011，17，6： | 1 |
| 19 | Glutathione peroxidase protects mice from viral-induced myocarditis 显示文摘 | Beck MA Esworthy RS Ho YS | 1998 | FASEB J1998，12，12： | 1 |
| 20 | Glutathione peroxidase protects mice from viral-induced myoearditis 显示文摘 | Beck M A Esworthy R S Ho Y S | 1998 | FASEB J1998，12，12： | 1 |
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