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| 1 | Altered vasoactive intestinal peptides expression in irritable bowel syndrome patients and rats with trinitrobenzene sulfonic acid-induced colitis显示文摘AIM: To investigate the vasoactive intestinal peptides(VIP) expression in irritable bowel syndrome(IBS) and trinitrobenzene sulfonic acid(TNBS) induced colitis.METHODS: The VIP gene expression and protein plasma levels were measured in adult participants(45.8% male) who met Rome Ⅲ criteria for IBS for longer than 6 mo and in a rat model of colitis as induced by TNBS.Plasma and colons were collected from naive and inflamed rats.Markers assessing inflammation(i.e.,weight changes and myeloperoxidase levels) were assessed on days 2,7,14 and 28 and compared to controls.Visceral hypersensitivity of the rats was assessed with colo-rectal distension and mechanical threshold testing on hind paws.IBS patients(n = 12) were age,gender,race,and BMI-matched with healthy controls(n = 12).Peripheral whole blood and plasma from fasting participants was collected and VIP plasma levels were assayed using a VIP peptide-enzyme immunoassay.Human gene expression of VIP was analyzed using a custom PCR array.RESULTS: TNBS induced colitis in the rats was confirmed with weight loss(13.7 ± 3.2 g) and increased myeloperoxidase activity.Visceral hypersensitivity tocolo-rectal distension was increased in TNBS treated rats up to 21 d and resolved by day 28.Somatic hypersensitivity was also increased up to 14 d post TNBS induction of colitis.The expression of an inflammatory marker myeloperoxidase was significantly elevated in the intracellular granules of neutrophils in rat models following TNBS treatment compared to naive rats.This confirmed the induction of inflammation in rats following TNBS treatment.VIP plasma concentration was significantly increased in rats following TNBS treatment as compared to naive animals(P < 0.05).Likewise,the VIP gene expression from peripheral whole blood was significantly upregulated by 2.91-fold in IBS patients when compared to controls(P < 0.00001; 95%CI).VIP plasma protein was not significantly different when compared with controls(P = 0.193).CONCLUSION: Alterations in VIP expression may play a role in IBS.Therefore,a better understanding of the physiology of VIP could lead to new therapeutics. | Arseima Y Del Valle-Pinero LeeAnne B Sherwin Ethan M Anderson Robert M Caudle Wendy A Henderson | 2015 | World Journal of Gastroenterology2015，21，1： | 7 |
| 2 | The missing voice of patients in drug: safety reporting 显示文摘 | Ethan B | 2010 | N Engl J Med2010，11，3： | 1 |
| 3 | Highspeedimaging of transient diesel spray behavior duringhigh pressure injection of a multi-hole fuel injector显示文摘 | Ethan Eagle W Morris S B Wooldridge M S | 2014 | 116(1) :299-3092014，116，1： | 1 |
| 4 | Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2显示文摘 | Sos Brandon C Harris Charles Nordstrom Sarah M Tran Jennifer L Balázs Mercedesz Caplazi Patrick Febbraio Maria Applegate Milana A B Wagner Kay-Uwe Weiss Ethan J | 2011 | Journal of Clinical Investigation2011，，4： | 1 |
| 5 | Antiemetics : Ameri- can Society of Clinical Oncology Clinical Practice Guideline Update 显示文摘 | Ethan B Prestrud A I-Iesketh PJ | 2011 | J Clin Oncol2011，29，41： | 1 |
| 6 | Kap stein' Workers and World Economy' 显示文摘 | Ethan B | 1996 | Foreign Affaires1996，75，3： | 1 |
| 7 | Therapeutic applications of Ienugreek 显示文摘 | Ethan B Catherine U Grace K | 2003 | Thorne Res2003，8，： | 1 |
| 8 | Agonistic properties of cannabidiol at 5-HT1a receptors显示文摘 | Ethan BR Andrea B Brian H | 2005 | Neurochem Res2005，30，8： | 1 |
| 9 | National kidney foundation practice guidelines for chronic kidney disease显示文摘 | Levey AS Coresh J Ethan B | 2003 | Ann Intern Med2003，139，2： | 1 |
| 10 | Transmission of Escherichia coli O157:H7 from contaminated manure and irrigation water to lettuce plant tissue and its subsequent internalization显示文摘 | Ethan B S Sima Y Karl R M | 2002 | Applied and Environmental Microbiology2002，68，1： | 1 |
| 11 | National kidney foundation prac- tice guidelines for chronic kidney disease: evaluation, classification, and stratification 显示文摘 | Andrew L Josef C Ethan B | 2003 | Clinical Guidelines2003，7，15： | 1 |
| 12 | Cross - flow microfiltration of low concentration - nonliving yeast suspensions显示文摘 | Keskinler B Yildiz E Ethan E | 2004 | J Membr Sci2004，233，12： | 1 |
| 13 | 显示文摘 | Ethan L G B | 1996 | Langmuir1996，12，： | 1 |
| 14 | Miniature Mass Analyzers显示文摘 | Ethan R B Cooks R G | 2000 | Mass Speetrom2000，35，： | 1 |
| 15 | Spatially correlated anomalous ^40Ar/^39Ar 'age' variations in biotites about a lithologic contact near Simplon Pass, Switzerland: A mechanistic explanation for excess Ar显示文摘 | Ethan F B Donald J D Paul R R | 2002 | Geochim et Cosmochim Acta2002，66，： | 1 |
| 16 | Disruption of the clock components CLOCK and BMAL1 leads to hypoinsuli- naemia and diabetes显示文摘 | Marcheva B Ramsey KM Ethan D | 2010 | Nature2010，466，7306： | 1 |
| 17 | Andrograpis paniculata for the treatment of upper respiratory infection显示文摘 | Benjamin K Catherine U Ethan B | | 0，，01： | 1 |
| 18 | The missing voice of patients in drug- safety reporting显示文摘 | Ethan B | 2010 | N Engl J Med2010，11，3： | 1 |
| 19 | Tumor necrosis factor-related apoptosis-inducing ligand and chemotherapy cooperate to induce apoptosis in mesothelioma cell lines显示文摘 | Weihong L Ethan B Jessica YC | 2001 | Am J Respire Cell Mol Biol2001，25，： | 1 |
| 20 | Antiemetics : American Socie- ty of Clinical Ontology Clinical Practice Guideline Update 显示文摘 | Ethan B Prestrud A Hesketh PJ | 2011 | J Clln Oncol2011，29，31： | 1 |
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