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| 1 | Effects of transcranial ultrasound stimulation pulsed at 40 Hz on Aβplaques and brain rhythms in 5×FAD mice显示文摘Background:Alzheimer's disease(AD)is the most common cause of dementia,and is characterized by amyloid-β(Aβ)plaques and tauopathy.Reducing Aβhas been considered a major AD treatment strategy in pharmacological and non-pharmacological approaches.Impairment of gamma oscillations,which play an important role in perception and cognitive function,has been shown in mouse AD models and human patients.Recently,the therapeutic effect of gamma entrainment in AD mouse models has been reported.Given that ultrasound is an emerging neuromodulation modality,we investigated the effect of ultrasound stimulation pulsed at gamma frequency(40 Hz)in an AD mouse model.Methods:We implanted electroencephalogram(EEG)electrodes and a piezo-ceramic disc ultrasound transducer on the skull surface of 6-month-old 5×FAD and wild-type control mice(n=12 and 6,respectively).Six 5×FAD mice were treated with two-hour ultrasound stimulation at 40 Hz daily for two weeks,and the other six mice received sham treatment.Soluble and insoluble Aβlevels in the brain were measured by enzyme-linked immunosorbent assay.Spontaneous EEG gamma power was computed by wavelet analysis,and the brain connectivity was examined with phase-locking value and cross-frequency phase-amplitude coupling.Results:We found that the total Aβ42 levels,especially insoluble Aβ42;in the treatment group decreased in pre-and infra-limbic cortex(PIL)compared to that of the sham treatment group.A reduction in the number of Aβplaques was also observed in the hippocampus.There was no increase in microbleeding in the transcranial ultrasound stimulation(tUS)group.In addition,the length and number of microglial processes decreased in PIL and hippocampus.Encel-phalographic spontaneous gamma power was increased,and cross-frequency coupling was normalized,implying functional improvement after tUS stimulation.Conclusion:These results suggest that the transcranial ultrasound-based gamma-band entrainment technique can be an effective therapy for AD by reducing the Aβload and improving brain connectivity. | Mincheol Park Gia Minh Hoang Thien Nguyen Eunkyung Lee Hyun Jin Jung Youngshik Choe Moon Hwan Lee Jae Youn Hwang Jae Gwan Kim Tae Kim | 2021 | Translational Neurodegeneration2021，10，4： | 2 |
| 2 | Wireless phototherapeutic contact lenses and glasses with red light-emitting diodes显示文摘Light-mediated therapeutics have attracted considerable attention as a method for the treatment of ophthalmologic diseases,such as age-related macular degeneration,because of their non-invasiveness and the effectiveness to ameliorate the oxidative stress of retinal cells.However,the current phototherapeutic devices are opaque,bulky,and tethered forms,so they are not feasible for use in continuous treatment during the patient’s daily life.Herein,we report wireless,wearable phototherapeutic devices with red light-emitting diodes for continuous treatments.Red light-emitting diodes were formed to be conformal to three-dimensional surfaces of glasses and contact lenses.Furthermore,fabricated light-emitting diodes had either transparency or a miniaturized size so that the user’s view is not obstructed.Also,these devices were operated wirelessly with control of the light intensity.In addition,in-vitro and in-vivo tests using human retinal epithelial cells and a live rabbit demonstrated the effectiveness and reliable operation as phototherapeutic devices. | Young-Geun Park Eunkyung Cha Hyeon Seok An Kyoung-Pil Lee Myoung Hoon Song Hong Kyun Kim Jang-Ung Park | 2020 | Nano Research2020，13，5： | 2 |
| 3 | EGF receptor ligands显示文摘 | Raymond C Harris Eunkyung Chung Robert J Coffey | 2003 | Experimental Cell Research2003，，1： | 1 |
| 4 | Monetary Policy, Land Prices, and Collateral Effects on Economic Fluctuations: Evidence from Japan 显示文摘 | Kwon Eunkyung | 1998 | Journal of the Japanese and International Economies1998，9，12： | 1 |
| 5 | Efficient Identity-based Authenticated Key Agreement Protocol from Pairings 显示文摘 | Choie Young Ju Jeong Eunkyung Lee Eunjeong | 2005 | Applied Mathematics and Computation2005，162，： | 1 |
| 6 | Monetary Policy, Land Prices, and Collat- eral Effects on Economic Fluctuations: Evidence from Japan显示文摘 | Eunkyung K | 1998 | Journal of the Japanese and International Economies1998，，3： | 1 |
| 7 | Amphiregulin causes function down regulation of adherens junctions in psoriasis显示文摘 | Eunkyung C Pau WC Charles AP | | 0，，06： | 1 |
| 8 | Toxicity value for 3-monochloropropane-1,2-diol using a benchmark dose methodology显示文摘 | HWANG Myungsil YOON Eunkyung KIM Jayoung | 2009 | Regulatory Toxicology and Pharmacology2009，53，2： | 1 |
| 9 | Toxicity value for 3- monochloropropane-1,2-diol using a benchmark dose methodology显示文摘 | yungsil H Eunkyung Y Jayoung K | 2009 | Regulatory Toxicology and Pharmacology2009，53，2： | 1 |
| 10 | Aberrant DNA methylation of integrin α4 in human breast cancer显示文摘 | Sung-Im Do Eunkyung Ko So Young Kang Jeong Eon Lee Seok Jin Nam Eun Yoon Cho Duk-Hwan Kim | 2014 | Tumor Biology2014，，7： | 1 |
| 11 | Location- Based TDMA MAC for Reliable Aeronautical Communica tions显示文摘 | Hyung Jun Jang Eunkyung Kim Jae Joon Lee | 2012 | IEEE Transactions on Aerospace and Electronic Systems2012，48，2： | 1 |
| 12 | Monetary Policy, Land Prices, and Collateral Effects on Economic Fluctuations: Evidence from Japan显示文摘 | Eunkyung Kwon | 1998 | Journal of the Japanese and International Economies1998，12，3： | 1 |
| 13 | Psy chophysical determination of moisture perception in highperformance shirt fabrics in relation to sweating level 显示文摘 | Eunkyung Jeon Shinjung Yoo Eunae Kim | 2011 | Ergonomics2011，54，6： | 1 |
| 14 | Elevated micro RNA ‐34a in obesity reduces NAD <sup>+</sup> levels and SIRT 1 activity by directly targeting NAMPT显示文摘 | Sung‐E Choi Ting Fu Sunmi Seok Dong‐Hyun Kim Eunkyung Yu Kwan‐Woo Lee Yup Kang Xiaoling Li Byron Kemper Jongsook K. Kemper | 2013 | Aging Cell2013，，6： | 1 |
| 15 | Overestimation and Underestimation: Adoles- cents' weight perception in comparison to BMI-based weight status and how it varies across socio-demographic factors显示文摘 | EUNKYUNG P | 2011 | Journal of School Health2011，81，2： | 1 |
| 16 | Analysis of muhimedia needs and searching features: An exploratory study 显示文摘 | Chung Eunkyung Yoon Jungwon | 2012 | Proceedings of the American Society for Information Science and Teehnology2012，49，1： | 1 |
| 17 | Amphiregulin causes func-tional downregulation ofadherensjunctions in psoriasis显示文摘 | Eunkyung C Paul WC Parkos CA | 2005 | J InvestDermatol2005，124，6： | 1 |
| 18 | Misexpression screen delineates novel genes controlling Drosophila lifespan显示文摘 | Donggi Paik Yeo Gil Jang Young Eun Lee Young Nam Lee Rochelle Yamamoto Heon Yung Gee Seungmin Yoo Eunkyung Bae Kyung-Jin Min Marc Tatar Joong-Jean Park | 2012 | Mechanisms of Ageing and Development2012，，5： | 1 |
| 19 | Severity of controlled cortical impact traumatic brain injury in rats and mice dictates degree of behavioral deficits显示文摘 | Seongjin Yu Yuji Kaneko Eunkyung Bae Christine E. Stahl Yun Wang Harry van Loveren Paul R. Sanberg Cesar V. Borlongan | 2009 | Brain Research2009，，： | 1 |
| 20 | An electrochemical immunosensor using ferrocenyl-tethered dendrimer显示文摘 | Seong J K Eunkyung K Haesik Y | 2006 | The Royal Society of Chemistry2006，131，： | 1 |
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