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| 1 | Relationship between LYVE-1, VEGFR-3 and CD44 gene expressions and lymphatic metastasis in gastric cancer显示文摘AIM: To investigate the expression levels of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), vascular endothelial growth factor receptor-3 (VEGFR-3) and CD44 genes and the relationship between their lev- els and clinicopathological parameters in gastric cancer.METHODS: Tissue samples were obtained from 33 patients (8 females) with gastric cancer. mRNA levels of LYVE-1, VEGFR-3 and CD44 in normal and tumor tissues were quantitatively measured using real time polymerase chain reaction. The results were correlated with lymph node metastasis, histological type and differentiation of the tumor, T-stage, and presence of vascular, perineural and lymphatic invasions. The distribution of molecules in the tissue was evaluated using immunohistochemistry. RESULTS: LYVE-1, CD44 and VEGFR-3 gene expression levels were significantly higher in gastric cancer than in normal tissue. While there was no correlation between gene expressions and clinicopathologic fea- tures such as histologic type, differentiation and stage, gene expression levels were found to be increased in conjunction with positive lymph node/total lymph node ratio and the presence of perineural invasion. A significant correlation was also found between LYVE-1 and CD44 over-expressions and perineural invasion and lymph node positivity in gastric cancers. When the dis- tribution of LYVE-1 antibody-stained lymphatic vessels in tissue was evaluated, lymphatic vessels were located intra-tumorally in 13% and peri-tumorally in 27% of the patients. Moreover, lymph node metastases were also positive in all patients with LYVE-1-staining. CONCLUSION: LYVE-1, VEGFR-3 and CD44 all play an important role in lymphangiogenesis, invasion and metastasis. LYVE-1 is a perfectly reliable lymphatic vessel marker and useful for immunohistochemistry. | Fusun Ozmen M Mahir Ozmen Evren Ozdemir Munevver Moran Selda Sekin Dicle Guc Ergun Karaagaoglu Emin Kansu | 2011 | World Journal of Gastroenterology2011，17，27： | 27 |
| 2 | Cirrhotic cardiomyopathy:A cardiologist's perspective显示文摘Cardiac dysfunction is frequently observed in patients with cirrhosis, and has long been linked to the direct toxic effect of alcohol. Cirrhotic cardiomyopathy(CCM) has recently been identified as an entity regardless of the cirrhosis etiology. Increased cardiac output due to hyperdynamic circulation is a pathophysiological hallmark of the disease. The underlying mechanisms involved in pathogenesis of CCM are complex and involve various neurohumoral and cellular pathways, including the impaired β-receptor and calcium signaling, altered cardiomyocyte membrane physiology, elevated sympathetic nervous tone and increased activity of vasodilatory pathways predominantly through the actions of nitric oxide, carbon monoxide and endocannabinoids. The main clinical features of CCM include attenuated systolic contractility in response to physiologic or pharmacologic strain, diastolic dysfunction, electrical conductance abnormalities and chronotropic incompetence. Particularly the diastolic dysfunction with impaired ventricularrelaxation and ventricular filling is a prominent feature of CCM.The underlying mechanism of diastolic dysfunction in cirrhosis is likely due to the increased myocardial wall stiffness caused by myocardial hypertrophy,fibrosis and subendothelial edema,subsequently resulting in high filling pressures of the left ventricle and atrium.Currently,no specific treatment exists for CCM.The liver transplantation is the only established effective therapy for patients with end-stage liver disease and associated cardiac failure.Liver transplantation has been shown to reverse systolic and diastolic dysfunction and the prolonged QT interval after transplantation.Here,we review the pathophysiological basis and clinical features of cirrhotic cardiomyopathy,and discuss currently available limited therapeutic options. | Natig Gassanov Evren Caglayan Nasser Semmo Gero Massenkeil Fikret Er | 2014 | World Journal of Gastroenterology2014，20，42： | 18 |
| 3 | Long-term aspirin pretreatment in the prevention of cerulein-induced acute pancreatitis in rats显示文摘AIM:To investigate the effects of long term pretreatment with low-,medium-and high-dose aspirin(acetylsalicylic acid,ASA) on a model of acute pancreatitis(AP) induced in rats.METHODS:Forty male Wistar rats were used.Three experimental groups,each consisting of eight animals,received low-(5 mg/kg per day),medium-(150 mg/kg per day) and high-dose(350 mg/kg per day) ASA in supplemented pellet chow for 100 d.Eight animals,serving as the AP-control group,and another eight,serving as reference value(RV) group,were fed with standard pellet chow for the same period.After pretreatment,AP was induced in the experimental animals by intraperitoneal administration of cerulein(2 × 50 μg/kg),while the RV group received saline in the same way.Twelve hours after the second injection,the animals were sacrificed.Pancreatic tissue and plasma samples were collected.One part of the collected pancreatic tissues was used for histopathological evaluation,and the remaining portion was homogenized.Cytokine levels [tumor necrosis factor,interleukin(IL)1β,IL-6],hemogram parameters,biochemical parameters(amylase and lipase),nuclear factor-κB,aspirin triggered lipoxins and parameters related to the antioxidant system(malondialdehyde,nitric oxide,hemeoxygenase-1,catalase and superoxide dismutase) were measured.RESULTS:Cerulein administration induced mild pancreatitis,characterized by interstitial edema(total histopathological score of 5.88 ± 0.44vs 0.25 ± 0.16,P < 0.001).Subsequent pancreatic tissue damage resulted in an increase in amylase(2829.71 ± 772.48 vs 984.57 ± 49.22 U/L,P = 0.001) and lipase(110.14 ± 75.84 U/L vs 4.71 ± 0.78 U/L,P < 0.001) in plasma,and leucocytes(6.89 ± 0.48 vs 4.36 ± 0.23,P = 0.001) in peripheral blood.Cytokines,IL-1β(18.81 ± 2.55 pg/μg vs 6.65 ± 0.24 pg/μg,P = 0.002) and IL-6(14.62 ± 1.98 pg/μg vs 9.09 ± 1.36 pg/μg,P = 0.04) in pancreatic tissue also increased.Aspirin pretreatment reduced the increase in the aforementioned parameters to a certain degree and partially improved the histopathological alterations caused by cerulein.No evidence of side effects related to chronic ASA administration(e.g.,inflammation or bleeding) was observed in the gastrointestinal tract in macroscopic and histopathological examination.CONCLUSION:Long term ASA pretreatment could prevent and/or ameliorate certain hematological,serological and histological alterations caused by ceruleininduced AP. | Ibrahim Akyazi Evren Eraslan Ahmet Gülubuk Elif Ergül Ekiz Zeynep L rakli Damla Haktanir Deniz Aktaran Bala Mete zkurt Erdal Matur Mukaddes zcan | 2013 | World Journal of Gastroenterology2013，19，19： | 5 |
| 4 | Biological performance of particleboard incorporated with boron minerals显示文摘We compared resistance to decay, mold fungi,termites and insect larvae of particleboards incorporated with the raw boron minerals ulexite and colemanite to that of particleboards impregnated with the commercial boron preservative zinc borate, or boric acid plus a borax mixture.We also quantified water absorption, thickness swell and boron release of particleboards. Ulexite had the best decay resistance, and colemanite had the best termite resistance.However, ulexite and colemanite were not as effective as zinc borate or the boric acid/borax mixture in preventing mold growth. In general, the boric acid/borax mixture combination was more effective against Anobium larvae than the other treatments. Less boron was released by specimens containing zinc borate and colemanite than bythose containing ulexite or the boric acid/borax mixture. In general, water absorption and thickness swell were similar among the different treatments, but both were slightly higher in the ulexite-incorporated specimens. Further mechanical tests will be needed to evaluate the particleboard properties and thereby the compatibility of these boron minerals with various manufacturing processes. | Evren Terzi S.Nami Kartal Philippe Gerardin Claudia Marcela Ibanez Tsuyoshi Yoshimura | 2017 | Journal of Forestry Research2017，28，1： | 4 |
| 5 | Biological performance,water absorption,and swelling of wood treated with nano-particles combined with the application of Paraloid B72~显示文摘We evaluated fungal decay and mold resistance,leaching, and water absorption of nano-compounds and Paraloid B72~(PB72) in treated wood specimens to develop new methods of consolidation by combining nanoparticles and consolidants. Scots pine wood specimens were treated with dispersions of nano-Cu O, nano-Zn O,nano-B_2O_3, nano-Ti O_2, and nano-Ce O_2. PB72 treatments of nano-particle-treated wood specimens were then carried out by either vacuum or immersion for 24 h. Previously,decayed wood specimens were also consolidated with the nano-compounds and PB72. PB72 treatments reduced element release from treated wood specimens. Nearly all nano-compounds ? PB72 treatments increased the biological performance of treated wood specimens against decay fungi tested. PB72-only treated wood specimens had the highest weight losses in decay tests. No improvements were obtained in mold resistance tests when the nanocompounds and PB72 were combined. In nano-compoundonly treatments, unleached specimens showed slightly lower water absorption values compared to untreated control specimens. Incorporation of PB72 into nano-compound-treated wood specimens resulted in considerably lower water absorption and volumetric swell. In previously decayed specimens treated with the nano-compounds and PB72 solution, water absorption after 2-h immersion declined compared to control specimens. | Damla Muhcu Evren Terzi S.Nami Kartal Tsuyoshi Yoshimura | 2017 | Journal of Forestry Research2017，28，2： | 3 |
| 6 | Recent trends on wound management:New therapeutic choices based on polymeric carriers显示文摘Wound healing is an unmet therapeutic challenge among medical society since wound assessment and management is a complex procedure including several factors playing major role in healing process.Wounds can mainly be categorized as acute or chronic.It is well referred that the acute wound displays normal wound physiology while healing,in most cases,is seemed to progress through the normal phases of wound healing.On the other hand,a chronic wound is physiologically impaired.The main problem in wound management is that the majority of wounds are colonized with microbes,whereas this does not mean that all wounds will be infected.In this review,we address the problems that clinicians face to manage while treat acute and chronic wounds.Moreover,we demonstrate the pathophysiology,etiology,prognosis and microbiology of wounds.We further introduce the state of art in pharmaceutical technology field as part of wound management aiming to assist health professionals to overcome the current implications on wound assessment.In addition,authors review researches which included the use of gels and dermal films as wound healing agents.It can be said that natural and synthetic drugs or carriers provide promising solutions in order to meet the wound management standards.However,are the current strategies as desirable as medical society wish? | Mehmet Evren Okur Ioannis D.Karantas Zeynep Senyigit Neslihan Ustundag Okur Panoraia I.Siafaka | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，6： | 3 |
| 7 | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study显示文摘Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis. | Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 8 | Current update on nanoplatforms as therapeutic and diagnostic tools:A review for the materials used as nanotheranostics and imaging modalities显示文摘In the last decade,the use of nanotheranostics as emerging diagnostic and therapeutic tools for various diseases,especially cancer,is held great attention.Up to date,several approaches have been employed in order to develop smart nanotheranostics,which combine bioactive targeting on specific tissues as well as diagnostic properties.The nanotheranostics can deliver therapeutic agents by concomitantly monitor the therapy response in real-time.Consequently,the possibility of over-or under-dosing is decreased.Various non-invasive imaging techniques have been used to quantitatively monitor the drug delivery processes.Radiolabeling of nanomaterials is widely used as powerful diagnostic approach on nuclear medicine imaging.In fact,various radiolabeled nanomaterials have been designed and developed for imaging tumors and other lesions due to their efficient characteristics.Inorganic nanoparticles as gold,silver,silica based nanomaterials or organic nanoparticles as polymers,carbon based nanomaterials,liposomes have been reported asmultifunctional nanotheranostics.In this review,the imaging modalities according to their use in various diseases are summarized,providing special details for radiolabeling.In further,the most current nanotheranostics categorized via the used nanomaterials are also summed up.To conclude,this review can be beneficial for medical and pharmaceutical society as well as material scientists who work in the field of nanotheranostics since they can use this research as guide for producing newer and more efficient nanotheranostics. | Panoraia I.Siafaka Neslihan Ustundag Okur Ioannis D.Karantas Mehmet Evren Okur Evren Atlihan Gundogdu | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，1： | 3 |
| 9 | Highly efficient three-phase grid-connected parallel inverter system显示文摘In this paper, a new three-phase grid-connected inverter system is proposed. The proposed system includes two inverters. The main inverter, which operates at a low switching frequency, transfers active power to the grid. The auxiliary inverter processes a very low power to compensate for the grid current ripple. Thus, no active power is processed by the auxiliary inverter. The goal is to produce a grid current with a low total harmonic distortion(THD) and to obtain the highest efficiency from the inverter system. The main inverter is controlled via a space-vector pulse-width modulation owing to its optimum switching pattern, and the auxiliary inverter is controlled via a hysteresis current-control technique owing to the technique's fast dynamic response. The proposed system is analyzed in terms of different DC-link voltage, switching frequency,and filter inductance values. The optimum system parameters are selected that provide a THD value of less than 5%.A prototype inverter system at a 10 kW output power has been implemented. The main inverter operates at a 3 kHz switching frequency, and the auxiliary inverter compensates for the grid-current ripple. In total, a THD of 4.33%and an efficiency of 97.86% are obtained using the proposed inverter system prototype. | Evren ISEN Ahmet Faruk BAKAN | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，5： | 2 |
| 10 | Relationship of internet addiction severity with depression,anxiety,and alexithymia, temperament and character in university students显示文摘 | Dalbudak E Evren C Aldemir S | 2013 | Cyberpsy- chology Behavior and Social Networking2013，16，4： | 1 |
| 11 | A robotic indenter for minimally invasive measurement and characterization of soft tissue response 显示文摘 | Evren S Mert S Cagatay B | 2007 | Medical Image Analysis2007，11，4： | 1 |
| 12 | Development and evaluation of coenzyme Q10 loaded solid lipid nanoparticle hydrogel for enhanced dermal delivery显示文摘 | Emrah K Evren H G Ozgen O | 2014 | Acta Pharmaceutica(zagreb Croatia)2014，63，4： | 1 |
| 13 | Spatial variability of exchangeable sodium, electrical conductivity, soil pH and boron content in salt -and sodium- affected areas of the Igdir plain(Turkey) 显示文摘 | Ardahanlioglu Ozas O T Evren S | 2003 | Journal of Arid Environments2003，54，： | 1 |
| 14 | Spatial variability of exchangeable sodium, electrical conductivity, soil pH and boron content in salt and sodium a{{ected areas of the Igdir plain (Tur- key) 显示文摘 | Ardabanlioglu O (-)ztas T Evren S | 2003 | Journal of Arid Environments2003，54，3： | 1 |
| 15 | Self-mutilative behaviours in male alcohol-dependent inpatients and relationship with posttraumatic stress disorder显示文摘 | Evren C Dalbudak E Evren B | | 0，，186： | 1 |
| 16 | Fracture resistance of manually and CAD/CAM manufactured ceramic onlays 显示文摘 | Yildiz C Vanholu BA Evren B | 2013 | J Prosthodont2013，22，7： | 1 |
| 17 | Characterization of waterborne acrylic based paint films and measurement of their water vapor permeabilities显示文摘 | Balkose D Gokcel I H Evren G S | 2001 | Eur Polym I2001，37，： | 1 |
| 18 | Investigation of 99mTc Labeled Clioquinol Derivative on Amyloid Plaque Specifity by Using Animal Model of Alzheimer's Disease 显示文摘 | Kllcar AY Miiftuler FZB Evren V | 2015 | Mol Imaging Radionucl Ther2015，24，： | 1 |
| 19 | In vitro activity of fosfomycin in combination with imipenem, meropenem, colistin and tigecycline against OXA 48–positive Klebsiella pneumoniae strains显示文摘 | Evren E AzapO K Colakoglu S | 2013 | Diagnostic Microbiology and Infectious Disease2013，76，3： | 1 |
| 20 | Leveraging A Personalized System to Improve Self-Directed Learning in Online Educational Environments显示文摘 | Rosemary Kim Lorne Olfman Terry Ryan Evren Eryilmaz | 2014 | Computers & Education2014，70，1： | 1 |
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