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| 1 | Effect of diminazene aceturate,levamisole and vitamin C combination therapy in rats experimentally infected with Trypanosoma brucei brucei显示文摘Objective:To investigate the effect of diminazene aceturale(DA) alone or in combination with either levamisole and/or Vitamin C in albino rats experimentally infected with Trypanosoma brucei brucei.Methods:Thirty adult male albino rats,randomly assigned into 6 groups(A—F) of 5rats each were used.They were either infected with 1×10~a trypanosomes intraperitoneally(groups A-E) or uninfected(group F).The different groups were treated respectively as follows:group A-with 3.5 mg/kg DA;group B-3.5 mg/kg DA and 7.5 mg/kg levamisole;group C-3.S mg/kg DA and 100 mg/kg vitamin C;and group D-3.S mg/kg DA and 7.S mg/kg levamisole and 100 mg/kg vitamin C.Croup E was left untreated.Parameters assessed include:rectal temperature,body weight changes,packed cell volume(PCV),Haemoglobin concentration(Hb),total leucocyte count(TLC) differential leucocyte count(DLC),parasitaemia,clinical signs and survivability.Results:Average pre-patent period of 5 days was recorded.Parasites in the blood were cleared in all treated groups(A-D) within 48 hours post treatment(PT).Untreated rats in group E died between25 and 32 days post infection(PI).Relapse was not recorded in all the treated groups(A-D).The initial reduction in PCV,Hb,TLC and increases in rectal temperature following infection were reversed by the treatments.The rats that received drug combinations(groups B,C and D)showed faster and higher recovery rates than the uninfected control and group A.Conclusions:Levamisole and/or Vitamin C combination with DA were more effective in the treatment of rats infected with Trypanosoma brucei brucei. | Adieme Ijeoma Chekwube Ezeh Ikenna Onyema Ugochukwu Emmanuel Ikenna Romanus Chukwuduruo Ezeokonkwo | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，6： | 3 |
| 2 | Human embryonic stem cell genes OCT4,NANOG,STELLAR,and GDF3 are expressed in both seminoma and breast carcinoma显示文摘 | Ezeh UI Turek PJ Reijo RA | 2005 | Cancer2005，104，10： | 1 |
| 3 | Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are ex pressed in both seminoma and breast carcinoma 显示文摘 | Ezeh U I Turek P J Reijo R A | 2005 | Cancer2005，104，10： | 1 |
| 4 | Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma显示文摘 | Ezeh UI Turek PJ Heijo RA | 2005 | Cancer2005，104，10： | 1 |
| 5 | Human embryonic stem cells gene OCT4,NANOG,STELLAR,and GDF3 are expressed in both seminoma and breast carcinoma显示文摘 | Ezeh UI Turek PJ Reijo RA | 2005 | Cancer2005，104，10： | 1 |
| 6 | Human embryonic stem cell genes OCT4,NANOG,STEILAR,and GDF3 are expressed in both seminoma and breast carcinoma显示文摘 | Ezeh UI Turek PJ Reijo RA | 2005 | Cancer2005，104，10： | 1 |
| 7 | Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma显示文摘 | Ezeh UI Turek PJ Reijo RA | 2005 | Cancer2005，104，10： | 1 |
| 8 | Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 arc expressed in both seminoma and breast carcinoma 显示文摘 | Ezeh U I Turek P J Reijo R A | 2005 | Cancer2005，104，10： | 1 |
| 9 | Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma 显示文摘 | Ezeh UI Turek PJ Reijo RA | 2005 | Cancer2005，104，10： | 1 |
| 10 | Human embryonic stem cell genes OCT4,NANOG,STELLAR,and GDF3 are expressed in both seminoma and breast carcinoma显示文摘 | Ezeh UI Turek PJ Redo RA | 2005 | Cancer2005，104，10： | 1 |
| 11 | Human embryonic stem cell genes cell gene OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma 显示文摘 | Ezeh UI Turek PJ Reijo RA | 2005 | Cancer2005，104，10： | 1 |
| 12 | Human embryonic stem cell genes OCT4,NANOG,STELLAR,and GDF3 are expressed in both seminoma and breast carcinoma显示文摘 | Ezeh UI Turek PJ Reijo RA | 2005 | Cancer2005，104，10： | 1 |
| 13 | Urban–rural differences in the socioeconomic deprivation–Sexual behavior link in Kenya显示文摘 | F. Nii-Amoo Dodoo Eliya M. Zulu Alex C. Ezeh | 2006 | Social Science & Medicine2006，，5： | 1 |
| 14 | Human embryonic stem cell genes OCT4,NANOG,STELLAR,and GDF3 are expressed in both seminoma and breast carcinoma显示文摘 | EZEH U I TUREK P J REIJO R A | 2005 | Cancer2005，104，10： | 1 |
| 15 | Human embryonicstem cell genes OCT4,NANOG,STELLAR,and GDF3 are ex-pressed in both seminoma and breast carcinoma显示文摘 | EZEH U I TUREK P J REIJO R A | 2005 | Cancer2005，104，10： | 1 |
| 16 | Human embryonic stem cell genes OCT4, NANOG, STELLAR,and GDF3 are expressed in both seminoma and breast carcinoma 显示文摘 | Ezeh U I Turek P J Reijo R A | 2005 | Cancer2005，104，： | 1 |
| 17 | Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma显示文摘 | Ezeh UI Turek PJ Reuo RA | 2005 | Cancer2005，104，15： | 1 |
| 18 | Effect of age on testicular function in adult males with sickle cell anemia显示文摘 | Modebe O Ezeh UO | 1995 | Fertil Steril1995，63，4： | 1 |
| 19 | Human embryonic stem cell genes OCT4,NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma 显示文摘 | Ezeh UI Turek PJ Reijo RA | 2005 | Cancer2005，104，10： | 1 |
| 20 | Human embryonic stem cell genes OCT4,NANOG,STELLAR,and GDF3 are expressed in both seminoma and breast carcinoma显示文摘 | Ezeh UI Turek PJ Reijo RA | 2005 | Cancer2005，104，10： | 1 |
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