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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | Identification and occurrence of tetrad-forming Alphaproteobacteria in anaerobic-aerobic activated sludge processes 显示文摘 | WONG M T TAN F M NG W J | 2004 | Microbiology2004，150，： | 1 |
| 4 | The 1982 revised criteria for the classification of systemic lupus erythematosus (SLE)显示文摘 | TAN E M COHEN A S FRIES J F | 1982 | Arthritis Rheum1982，25，11： | 1 |
| 5 | Genetic bases of appearance quality of rice grains in Shanyou 63, an elite rice hybrid显示文摘 | Tan Y F Li J X Yu S B et a1 | 2000 | Theor Appl Genet2000，101，56： | 1 |
| 6 | Concentration and mode of occurrence of trace elements in marine oil shale from the Bilong Co area,northern Tibet,China显示文摘 | FU X G WANG J ZENG Y H TAN F W FENG X L | | 0，，01： | 1 |
| 7 | Ambulatory pH measurements at the upper esophageal sphincter显示文摘 | SMIT C F TAN J DEVRIESE P P | 1998 | Laryngoscope1998，108，： | 1 |
| 8 | The Late Triassic rift-related vol- canic rocks from eastern Qiangtang, northern Tibet (China): Age and tectonic implications显示文摘 | Fu X G Wang J Tan F W | 2010 | Gondwana Research2010，17，1： | 1 |
| 9 | Decomposition of Abies faxoniana litter varies with freeze–thaw stages and altitudes in subalpine/alpine forests of southwest China 显示文摘 | Zhu J He X Wu F Yang W Tan B | 2012 | Scand J For Res2012，27，： | 1 |
| 10 | Tuning of PID controllers for boiler-turbineunits显示文摘 | Tan W Liu J Z Fang F | 2004 | ISATransactions2004，43，4： | 1 |
| 11 | The three important traits for cooking and eating quality of rice grains are controlled by a single locus in an elite rice hybrid,Shan you 63显示文摘 | Tan Y F Li J X Yu S B | 1999 | Theor Apll Genet1999，99，： | 1 |
| 12 | Effects of addition of anka rice on the qualities of low-nitrite Chinese sausages显示文摘 | Liu D C Wu S W Tan F J | 2010 | Food Chemistry2010，118，2： | 1 |
| 13 | Furstenherg families and eham 显示文摘 | XIONG J C LV J TAN F | 2007 | Seieneee in China:Ser A2007，50，9： | 1 |
| 14 | Surface functionalization of BaTiO3 nanoparticles and improved electrical properties of BaTiO3/polyvinylidene fluoride composite显示文摘 | Lin M F Thakur V K Tan E J | 2011 | RSC Adv2011，1，4： | 1 |
| 15 | 查看详情显示文摘 | Cui S F Tan S Ouyang G F Pawliszyn J | | 0，，12： | 1 |
| 16 | Simulating unsteady aerodynamics of helicopter rotor with panel/viscous vortex particle method显示文摘 | Tan J F Wang H W | 2013 | Aerospace Science and Technology2013，30，1： | 1 |
| 17 | Singularities in motion and displacement functions of spatial link- ages 显示文摘 | LITVIN F L FANGHELLA P TAN J | 1986 | ASME Journal of Mechanism Transmission and Automation in Design-Transactions1986，108，4： | 1 |
| 18 | Atmospheric mercury deposition in Guizhou, China显示文摘 | Tan H He J L Liang L Lazoff S Sommer J Xiao Z F Lindqvist O | 2000 | The Science of the Total Environment2000，259，13： | 1 |
| 19 | The 1982 revised criteria for the classification of systemic lupus erythematosus 显示文摘 | TAN E M COHEN A S FRIES J F | 1982 | Arthritis Rheum1982，25，11： | 1 |
| 20 | Antioxidative properties of a chitosan-glucose Maillard reaction product and its effect on pork qualities during refrigerated storage显示文摘 | H L Chang Y C Chen F J Tan | 2011 | Food Chemistry2011，124，： | 1 |
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