|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ghrelin attenuates gastrointestinal epithelial damage induced by doxorubicin显示文摘AIM:To examine the influence of ghrelin on the regenerative potential of gastrointestinal(GI)epithelium.METHODS:Damage to GI epithelium was induced in mice by two intravenous injections of doxorubicin(10 and 6 mg/kg).Some of the doxorubicin-treated mice received a continuous subcutaneous infusion of ghrelin(1.25μg/h)for 10 d via implanted mini-osmotic pumps.To label dividing stem cells in the S-phase of the cell cycle,all mice received a single intraperitoneal injection of 5'-bromo-2'-deoxyuridine(BrdU)one hour before sacrifice.The stomach along with the duodenum were then removed and processed for histological examination and immunohistochemistry using anti-BrdU antibody.RESULTS:The results showed dramatic damage to the GI epithelium 3 d after administration of chemotherapy which began to recover by day 10.In ghrelintreated mice,attenuation of GI mucosal damage was evident in the tissues examined postchemotherapy.Immunohistochemical analysis showed an increase in the number of BrdUlabeled cells and an alteration in their distribution along the epithelial lining in response to damage by doxorubicin.In mice treated with both doxorubicin and ghrelin,the number of BrdUlabeled cells was reduced when compared with mice treated with doxorubicin alone.CONCLUSION:The present study suggests that ghrelin enhances the regenerative potential of the GI epithelium in doxorubicintreated mice,at least in part,by modulating cell proliferation. | Mohamed A Fahim Hazem Kataya Rkia El-Kharrag Dena AM Amer Basel al-Ramadi Sherif M Karam | 2011 | World Journal of Gastroenterology2011，17，33： | 3 |
| 2 | CLM4.5对中国区域夏季土壤湿度的模拟研究显示文摘利用CESM (Community Earth System Model)框架最新发布的陆面模式CLM4.5模拟得到中国区域1991~ 2010年7月份0~ 10 cm的土壤湿度数据集;并以中国农作物生长发育和农田土壤湿度旬值数据集的土壤湿度作为实测值,与模拟结果进行了比较分析.结果表明CLM4.5能够揭示中国区域7月份0~10 cm土壤湿度的空间分布特征,与实测数据土壤湿度的年际变化趋势保持着较好的一致性.利用曼-肯德尔法进行突变现象检测表明,模拟和实测得到的二十年的土壤湿度在华北、东北地区有逐年减小的趋势,尤其是东北地区土壤变干现象尤为明显;而华东、华中地区的土壤湿度以2~3年为周期增减,并没有一个持续稳定的变化趋势.CLM4.5模拟的土壤湿度值普遍偏高,最大偏差超过0.1 mm3·mm-3,这可能与模式的参数化方案有关,在以今后的研究中有待进一步探索. | 王迪 沈润平 师春香 李明 张悦 Ahmad M Fahim | 2015 | 科学技术与工程2015，35，17： | 3 |
| 3 | Low-power direct digital frequency synthesis for wireless communications 显示文摘 | BELLAOUAR A OBRECHT M S FAHIM A M | 2000 | IEEE Journal of Solid-State Circuits2000，35，3： | 1 |
| 4 | Hairpin RNAderived from viral NIa gene confers immunity to wheat streakmosaic virus infection in transgenic wheat plants显示文摘 | Fahim M Ayala-Navarrete L Miller A A | 2010 | Plant Bi-otechnology Journal2010，8，7： | 1 |
| 5 | Liquid-liquid equilibria for the extraction of aromatics from naphtha reformate by dimethylformamide/ethylene glycol mixed solvent显示文摘 | Radwan G M Fahim M A Almuhtaseb S A | 1997 | Fluid Phase Equilibria1997，129，12： | 1 |
| 6 | Cardiovascular toxicity of ionophores used as feed additives 显示文摘 | Pressman BC Fahim M | 1983 | Adv Exp Med Biol1983，161，： | 1 |
| 7 | Prediction of predominant mechanisms in the separation of secondary disperstions in a fibrous bed显示文摘 | Othamn F M Fahim M A Jeffreys G V | 1988 | Dispersion Science and Technology1988，9，2： | 1 |
| 8 | Influence of foaming agent on wear and mechanical properties of surface modified rice husk filled polyvinylchloride显示文摘 | CHAND N FAHIM M SHARMA P | 2012 | Wear2012，，： | 1 |
| 9 | Optimization of aromatics extraction of naphtha reformate by propylene carbonate/diethylene glycol mixed solvent显示文摘 | Lababidi H M S Ali S H Fahim M A | 2006 | Industrial & Engineering ChemistryResearch2006，45，14： | 1 |
| 10 | Growth and characterization of anodic films on alumi-num alloys in 5-sulfosalicylic acid solution显示文摘 | Morks M F Abdel Salam Hamdy Fahim N F | 2006 | Surfaceand Coatings Technology2006，200，16： | 1 |
| 11 | Prediction and measurement of phase equilibria for the extraction of BTX from naphtha reformate using BMIMPF6 ionic liquid显示文摘 | A1-Rashed O A Fahim M A Shaaban M | 2014 | Fluid Phase Equilibria2014，363，： | 1 |
| 12 | Neural networks representation of a vehicle model:‘ Neuro - Vehicle (NV) '显示文摘 | Ghazizadeh A Fahim A El- Gindy M | 1996 | International Journal of Vehicle Design1996，17，1： | 1 |
| 13 | A wideband sigma-delta phase-locked-loop modulator for wireless applications显示文摘 | Fahim A M | 2003 | IEEE Trans Circ and SystⅡ:Analog and Dig Signal Proc2003，50，2： | 1 |
| 14 | The effect of explicit teaching of English“thanking formulas” on Iranian EFL intermediate level studentsat English language institutes 显示文摘 | Ghobadi A Fahim M | 2009 | System2009，37，3： | 1 |
| 15 | Low-power direct digital frequency synthesis for wireless communications显示文摘 | BELLAOURA A MICHAEL S FAHIM A M | 2000 | IEEE Journal of Solid-State Circuits2000，35，3： | 1 |
| 16 | Low-power direct digital frequency synthesis for wireless communications 显示文摘 | BELLAOUAR A O'BRECHT M S FAHIM A M | 2000 | IEEE J Sol Sta Circ2000，35，3： | 1 |
| 17 | Effect of aflatoxicosis on the kinetic behaviour of ceftiofur in chickens显示文摘 | Amer A M Fahim E M Ibrahim R K | 1998 | Research in Veteri- nary Science1998，65，2： | 1 |
| 18 | Low-power direct digital frequency synthesis for wireless communications显示文摘 | Bellaouar A O'brecht M S Fahim A M | 2000 | IEEE Journal of Solid-State Circuits2000，35，3： | 1 |
| 19 | Lowpower direct-digital frequency synthesis for wireless communication显示文摘 | BELLAOUAR A OBRECHT M S FAHIM A M | 2000 | IEEE Journal of Solid-Stated Circuits2000，35，3： | 1 |
| 20 | A fuzzy heuristic approach for predicting asphaltene precipitation potential 显示文摘 | Haitham M S Lababidi Ali A Garrouch Mohammed A Fahim | 2001 | Energy & Fuels2001，18，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员