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| 1 | Tumor necrosis factor-α-G308A polymorphism is associated with liver pathological changes in hepatitis C virus patients显示文摘AIM To investigate the association of tumor necrosis factor alpha(TNFα)-G308 A polymorphism with different liver pathological changes in treatment-na?ve Egyptian patients infected with hepatitis C virus(HCV) genotype 4.METHODS This study included 180 subjects,composed of 120 treatment-na?ve chronic HCV patients with different fibrosis grades(F0-F4) and 60 healthy controls. The TNFα-G308 A region was amplified by PCR and the different genotypes were detected by restriction fragment length polymorphism analysis. The TNFα protein was detected by enzyme-linked immunosorbent assay. The influence of different TNFα-G308 A genotypes on TNFα expression and liver disease progression were statistically analyzed. The OR and 95%CI were calculated to assess the relative risk confidence.RESULTS Current data showed that the TNFα-G308 A SNP frequency was significantly different between controls and HCV infected patients(P = 0.001). Both the AA genotype and A allele were significantly higher in late fibrosis patients(F2-F4,n = 60) than in early fibrosis patients(F0-F1,n = 60)(P = 0.05,0.04 respectively). Moreover,the GA or AA genotypes increased the TNFα serum level greater than the GG genotype(P = 0.002). The results showed a clear association between severe liver pathological conditions(inflammation,steatosis and fibrosis) and(GA + AA) genotypes(P = 0.035,0.03,0.04 respectively). The stepwise logistic regression analysis showed that the TNFα genotypes(GA + AA) were significantly associated with liver inflammation(OR = 3.776,95%CI: 1.399-10.194,P = 0.009),severe steatosis(OR = 4.49,95%CI: 1.441-14.0,P = 0.010) and fibrosis progression(OR = 2.84,95%CI: 1.080-7.472,P = 0.034). Also,the A allele was an independent risk factor for liver inflammation(P = 0.003),steatosis(P = 0.003) and fibrosis(P = 0.014). CONCLUSION TNFα SNP at nucleotide-308 represents an important genetic marker that can be used for the prognosis of different liver pathological changes in HCV infected | Noha G Bader El Din Sally Farouk Reem El-Shenawy Marwa K Ibrahim Reham M Dawood Mostafa M Elhady Ahmed M Salem Naglaa Zayed Ahmed Khairy Mostafa K El Awady | 2016 | World Journal of Gastroenterology2016，22，34： | 3 |
| 2 | Effect of diet and fat content on the func- tional properties of thawed beef显示文摘 | FAROUK M WIELICAKO K | 2003 | Meat Science2003，64，4： | 1 |
| 3 | Extracellular phytase activity of Bacillus amyloliquefaciens FZB45 contributes to its plant-growth-promoting effect 显示文摘 | Idriss EE Makarewicz O Farouk A Rosner K Greiner R Bochow H Richter T Borriss R | 2002 | Microbiology2002，148，7： | 1 |
| 4 | Meta-analysis of randomized eontrolled trials on the safety and effectiveness of day-case laparo- scopic cholecystectomy显示文摘 | Gurusamy K Junnarkar S Farouk M | 2008 | Br J Surg2008，95，2： | 1 |
| 5 | Cooked sausage batter cohesiveness as affected by sarcoplasmic proteins 显示文摘 | Farouk M M Wieliczko K Lira R | 2002 | MeatScience2002，61，1： | 1 |
| 6 | UK guidelines for the mangement of acute panceatitis 显示文摘 | Gurusamy K S Farouk M Tweedie J H | 2005 | Gut2005，54，3： | 1 |
| 7 | Ultra-fast freezing and low storage temperatures are not necessary to maintain the functional properties of manufacturing beef显示文摘 | FAROUK M M WIELICZKO K J MERTS I | 2004 | MeatScience2004，66，1： | 1 |
| 8 | Volatile constituent of glutathione-ribose model system and its antioxidant activity 显示文摘 | EI- massry K Farouk A EI- Ghorab A | 2003 | Amino Acids2003，24，： | 1 |
| 9 | Characterization of nutraceutical compounds in blue green alga Spirulina maxima显示文摘 | HANANA H El-BAKY A FAROUK K | 2008 | Global Journal of Biotechnology and Biochemistry2008，3，2： | 1 |
| 10 | An experimental study of heat transfer in a vertical annulus with a rotat- ing cylinder显示文摘 | BALL K S FAROUK B DIXIT V C | 1989 | Internation Journal of Heat Mass Transfer1989，32，： | 1 |
| 11 | Ultra-fast freezing and low storage temperatures are not necessary to maintain the functional properties of manufacturing beef显示文摘 | Farouk M M Wieliczko K J Merts I | 2003 | Meat Science2003，66，： | 1 |
| 12 | Electrophilic Radioiodinationof Tyrosine Derivatives显示文摘 | Farah K Farouk N | 1998 | J Labelled Compd Ra-diopharm1998，41，4： | 1 |
| 13 | Analysis of material recovery in plasma arc melting of solid wastes: a computational study 显示文摘 | Wenger A K Farouk B | 1999 | Air & Waste Manag Assoc1999，49，： | 1 |
| 14 | Uhra-fast freezing and low storage temperatures are not necessary to maintain the functional properties of manufacturing beef显示文摘 | Farouk M M Wieliczko K J Merts I | 2003 | Meat Science2003，66，： | 1 |
| 15 | Cooked sausage batter cohesiveness as affected by sarcoplasmic proteins显示文摘 | FAROUK M M WIELICZKO K LIM R | 2002 | Meat Science2002，61，1： | 1 |
| 16 | Wound sealing- related complications of 25-gauge vitrectomy in prolifera- tive diabetic retinopathy versus simple macular pathology 显示文摘 | Sayed K M NaitoT Farouk M M | 2011 | J Med Invest2011，58，12： | 1 |
| 17 | Ultra-fast freezing and low storage temperatures are not necessary to maintain the functional properties of manufacturing beef显示文摘 | Farouk M M Wieticzko K J Merts I | 2004 | Meat Science2004，66，1： | 1 |
| 18 | Ultra-fast freezing and low storage temperatures are not necessary to maintain the functional properties of manufacturing beef显示文摘 | M M Farouk K J Wieliczko I Merts | 2003 | Meat Sci2003，66，： | 1 |
| 19 | Ultra-fast freezing and low storage temperatures are not necessary to maintain the functional properties of manufacturing beef 显示文摘 | FAROUK M M WIELICZKO K J MERTS I | 2004 | Meat Science2004，66，1： | 1 |
| 20 | Meta-analysis of randomized controlled trials on the safety and effectiveness of day-case laparoscopic cholecystectomy显示文摘 | Gurusamy K Junnarkar S Farouk M | 2008 | Br J Surg2008，95，2： | 1 |
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