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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | The VIRGO study:nevirapine,didanosine and stavudine combination therapy in antiretroviral-naive HIV-l-infected adults显示文摘 | Raffi F Reliquet V Ferré V | | 0，，： | 1 |
| 3 | Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function 显示文摘 | Ferrada C Ferre S Casado V | 2008 | Neuropharmacology2008，55，： | 1 |
| 4 | Prevalence of psoriasis in Spain (Epiderma Project:phase Ⅰ)显示文摘 | Ferrándiz C Bordas X Garcia-Patos V | 2001 | J Eur Acad Dermatol Venereol2001，15，1： | 1 |
| 5 | Genetic variability of Hepatitis A virus in South America reveals heterogeneity and coeireulation during epidemic outbreaks 显示文摘 | Costa-Mattioli M Ferre V Monpoeho S | 2001 | J Gen Virol2001，82，11： | 1 |
| 6 | Comparison of 7 RNA extraction methods on stool and shellfish samples prior to hepatitis A virus amplification显示文摘 | Annal C Ferre - Aubineau V Besse B Mignotte B Schwartzbrod L Billaudel S | | J Virol Methods0，77，： | 1 |
| 7 | A novel combination of methane fermentation and MBR-Kubota Submerged Anaerobic Membrane Bioreactorprocess显示文摘 | Kanai M Ferre V Wakahara S | 2010 | Desalination2010，250，3： | 1 |
| 8 | Bagged knear est neighbours classification with uncertainty in the variables 显示文摘 | MEDINA J L V BOQUE R FERRE J | 2009 | Analytica Chimica Acta2009，646，1： | 1 |
| 9 | Turpentine-induced inflammation re- duces the hepatic expression of the multiple drug resistance gene, the plasma cholesterol concentration and the development of atherosclerosis in apolipoprotein E deficient mice 显示文摘 | Tous M Ribas V Ferre N | 2005 | Biochim Biophys Acta2005，1733，23： | 1 |
| 10 | A novel combination of methane fermentation and MBR-Kubota Submerged Anaerobic Membrane Bioreactor process显示文摘 | KANAI M FERRE V WAKAHARA S | 2010 | Desalination2010，250，3： | 1 |
| 11 | Phenolic compounds from brazihan propohs with pharmacological activities 显示文摘 | MARCUCCI M C FERRES F GARCIA V | 2001 | Journal of Ethnopharmacology2001，74，： | 1 |
| 12 | Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-lc on glycolytic and lipogenic gene expression显示文摘 | Dentin R P6gorier J P Benhamed F Foufelle F Ferr P Fauve- au V | 2004 | J Biol Chem2004，279，20： | 1 |
| 13 | Generation of llama single- domain antibodies against methotrexate, a prototypical hapten 显示文摘 | ALVAREZ- RUEDA N BEHAR G FERRE V | 2007 | Mol Immunol2007，44，7： | 1 |
| 14 | Preparation ofingredients containing an ACE-inhibitory peptide by tryptic hydroly-sis of whey protein concentrates 显示文摘 | FERR EIRA I PINHO O MOTAOTA M V | 2007 | International Dairy Journal2007，17，5： | 1 |
| 15 | A novel combination of methane fermentation and MBR - Kubota Submerged Anaerobic Membrane Bioreactor process显示文摘 | Kanai M Ferre V Wakahara S | 2010 | Desalination2010，250，3： | 1 |
| 16 | Cloning and molecular characterization of the Acyl-CoA: Diacylglycerol acyltransferase 1 (DGAT1) gene from echium显示文摘 | FERNA A M FERR M V G-CAJ A | 2009 | Lipids2009，44，： | 1 |
| 17 | An atypical presentationof a blastic plasmacytoid dendritic cell tumors 显示文摘 | L o pez V Mart N Ferr a ndez A | 2010 | J Cutan Pathol2010，37，9： | 1 |
| 18 | Nutrient effects on stand structure, resorption efficiency, and secondary compounds in everglades saw grass显示文摘 | Curtis R J Ferre|l G M Panchabi V | 1999 | Ecology1999，80，7： | 1 |
| 19 | Adenosine A2A-dopamine D2 receptor heteromers operate striatal function:impact on Parkinson's disease pharmacotherapeutics显示文摘The basal ganglia(BG)assemble a series of deep gray matter structures forming recurrent loops that include the cortex and thalamus,and that participate in the regulation of a plethora of brain functions,including elicitation and learning of reward-and aversive stimuli-associated behaviors,motor activity control and sensorimotor gating(Bromberg-Martin et al.,2010).The striatum is the main input | víctor fernández-duenas sergi ferré francisco ciruela | 2018 | Neural Regeneration Research2018，13，2： | 1 |
| 20 | Market and design considerations of the 37 larger MBR plants in Europe 显示文摘 | LESJEAN B FERRE V VONGHIA E | 2009 | Desalination and Water Treatment2009，6，123： | 1 |
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