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85篇 您的检索式:作者名="FESKE S"
    题名 作者 年代 出处 被引量
1Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed.Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost 2019Stroke & Vascular Neurology2019,4,4:2
2Orail is an essen- tial pore subunit of the CRAC channel 显示文摘PRAKRIYA M FESKE S GWACK Y 2006Nature2006,443,7108:1
3Signalling to transcription: store - operated Ca^2+ entry and NFAT activation in lymphocytes 显示文摘Gwack Y Feske S Srikanth S 2007Cell Calcium2007,42,2:1
4Calcium signalling in lymphocyte activation and disease显示文摘FESKE S 2007Nature Reviews Immunology2007,7,9:1
5A mutation in Orail causes immune deficiency by abrogating CRAC channel function 显示文摘Feske S Gwack Y Prakriya M 2006Nature2006,441,7090:1
6Gene regulation mediated by calcium signals in T lymphocytes 显示文摘Feske S Giltnane J Dolmetsch R 2001Nat Immunol2001,2,:1
7Gene regulation mediated by calcium signals in T lymphocytes 显示文摘Feske S Giltnane J Dolmetsch R 2001Nat Immunol2001,2,4:1
8A severe defect in CRAC Ca^2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients 显示文摘Feske S Prakriya M Rao A 2005J Exp Med2005,202,5:1
9Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis显示文摘Keefe D Shi L Feske S 0,,03:1
10A mutation in Orail causesimmune deficiency by abrogating CRAC channel function显示文摘Feske SY Gwack M Prakriya S 2006Nature2006,441,:1
11Calcium signalling in lymphocyte activation and disease 显示文摘Feske S 2007Nat Rev Immunol2007,7,9:1
12Biochemical and functional characterization of Orai proteins显示文摘Gwack Y Srikanth S Feske S 2007Biological Chemistry2007,282,16:1
13A minimal regulatory domain in the C terminus of STIM1 binds to and activates Orai1 CRAC channels显示文摘Kawasaki T Lange I Feske S 0,,:1
14Signalling to transcription: store-operated Ca^2+ entry and NFAT activation in lymphocytes 显示文摘GWACK Y FESKE S SRIKANTH S 2007Cell Calcium2007,42,2:1
15Signalling to transcription: store-operated Ca2 + entry and NF AT activation in lymphocytes 显示文摘Gwack Y Feske S Srikanth S 2007Cell Calcium2007,42,2:1
16Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis显示文摘Keefe D Shi L Feske S et a| 2005Immunity2005,23,3:1
17Preeclampsla and eclampsia: clinical and neroradiographic correlate and insights into the pathogenesis of hypertensive encephalopathy 显示文摘Schwartz R B Feske S K Polak J F 2000Radiology2000,217,2:1
18Biochemical and functional characterization of Orai proteins 显示文摘Gwack Y Srikanth S Feske S 2007J Biol Chem2007,282,16:1
19Conformational dynamics of STIM1 activa-tion显示文摘Feske S Prakriya M 0,,:1
20Gene regulation mediated by calcium signals in T lymphocytes 显示文摘Feske S Giltnane J Dolmetsch R 2001Nat Immunol2001,2,4:1
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