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| 1 | Electrical spin injection and accumulation at room temperature in an all-metal mesoscopic spin valve显示文摘 | Filip A T van Wees B J | 2001 | Nature2001，410，： | 1 |
| 2 | Is there a com- promise between nutrient uptake and gas exchange in the gut of Misgurnus anguillicaudatus, an intestinal air-breathing fish?显示文摘 | Goncalves A F Filipe L Cristina C | 2007 | Comparative Biochemistry and Physiology Part D: Genomics and Proteomics2007，2，34： | 1 |
| 3 | Vanadium haloperoxidases from brown algae of the Laminariaceae family显示文摘 | Almeida M Filipe S Humanes M Maia M F Melo R Severino N Da Silva J A L Da Silva J J R F Wever R | 2001 | Phytochemistry2001，57，： | 1 |
| 4 | Modern sports eye injuries显示文摘 | Capao Filipe J A Rocha-Sousa A Falcao-Reis F | 2003 | Bn J Ophthalmol2003，87，11： | 1 |
| 5 | Carbon nanotube field-effect transistor detector associated to gas chromatography for speciation of benzene, toluene, ethylbenzene, ( o-, m- and p-) xylene 显示文摘 | LURDES I B S FILIPE D P F TERESA A P R S | 2009 | Journal of Chromatography A2009，1216，37： | 1 |
| 6 | Contextual factors and the creativity of frontline employee:the mediating effects of role stress and intrinsic motivition显示文摘 | FILIPE C MARIO A LUIS F L | 2011 | Journal of Retailing2011，87，1： | 1 |
| 7 | Electrical spin injection and accumulation at room temperature in an all-metal meso- scopie spin valve 显示文摘 | Jedema F Filip A Van Wees B | 2001 | Nature2001，410，6826： | 1 |
| 8 | Cross-sectional study to determine viral hepatitis knowledge in different urban populations in Brazil显示文摘AIM To evaluate viral hepatitis knowledge among individuals from different resource areas and health conditions to identify possible gaps.METHODS A cross-sectional, descriptive study was carried out among 447 individuals from five distinct populations in Brazil: Southeast Viral Hepatitis Ambulatory(n = 100), South(n = 89) and Northeast(n = 114) Health Center, Southeast(n = 77) and Northeast(n = 67) low resource areas. All individuals answered a questionnaire assessing sociodemographic characteristics and viral hepatitis awareness. The perception was scored based on the average number of correct answers of all participants and categorized as 'low'(0-28 correct answers) or 'desirable'(29-46 correct answers). Associations between sociodemographic characteristics and perception were also evaluated.RESULTS A low level of knowledge was observed in individuals from Northeast Health Center, Northeast and Southeast low resource areas while desirable knowledge was observed in individuals from Viral Hepatitis Ambulatory and South Health Center. According to sociodemographic characteristics, desirable scores were more common among those with secondary education(47.1%), those who declared themselves as white(46.3%), and those who lived in houses with three individuals(25.5%). Multivariate analysis showed an association between viral hepatitis perception and type of population. CONCLUSION The results demonstrated high level of knowledge among study participants from health clinics from the Southeast region of Brazil and the importance of education programs in increasing the level of knowledge in low resource areas. | Helena Medina Cruz Jakeline Ribeiro Barbosa Jeová Keny Baima Colares Antonio Henrique Almeida de Moraes Neto Maria de Fátima Leal Alencar Francisco Inácio Bastos Jurema Corrêa da Mota Filipe Aníbal Carvalho-Costa Claudia Alexandra Pontes Ivantes Lia Laura Lewis-Ximenez Livia Melo Villar | 2018 | World Journal of Hepatology2018，10，11： | 1 |
| 9 | Decision Support for Blend Monitoring in Proce Induries显示文摘 | Filip F G Donciulescu A D Neagu G | 1998 | Computers in Indury1998，36，12： | 1 |
| 10 | Modeling of cyclic shear behavior in rc members 显示文摘 | Angelo D A Filip C F | 1999 | Journal of Structural Engineering ASCE1999，125，10： | 1 |
| 11 | Immunolocalization of bone morphogenetic protein 2 during the early healing events after guided bone regeneration显示文摘 | Andréa Carvalho De Marco Maria Aparecida Neves Jardini Filipe Modolo Fábio Daumas Nunes Luiz Antonio Pugliesi Alves de Lima | 2012 | Oral Surgery Oral Medicine Oral Pathology and Oral Radiology2012，，4： | 1 |
| 12 | Electrical spin injection and accumulation at room temperature in an all-metal mesoscopic spin valve显示文摘 | Jedema F J Filip A T Van Wees B | 2001 | Nature2001，410，： | 1 |
| 13 | Electrical spin injection and accumulation in room temperature in all-metal mesoscopic spin valve显示文摘 | Jedema F J Filip A T Van Wees B | 2001 | Natrue2001，410，： | 1 |
| 14 | Spatial model-ling of freshwater fish in semi-arid river systems:a tool for conserva-tion显示文摘 | FILIPE A F' COWX I G COLLARES-PEREIRA M J | 2002 | River Research and Applications2002，18，： | 1 |
| 15 | Modeling of cyclic shear behavior on remembers 显示文摘 | Angelo D A Filip C F | 1999 | Journal of Structural Engineering ASCE1999，125，10： | 1 |
| 16 | Performance of a yeast-me- diated biological fuel cell显示文摘 | GUNAWARDENA A G SANDUN F FILIP T | 2008 | Int J Mol Sci2008，9，： | 1 |
| 17 | Energy efficient building design using sensitivity analysis-A case study显示文摘 | P Filipe A F Tavares A Manuel O G Martins | 2007 | Energy and Buildings2007，39，1： | 1 |
| 18 | Nucleic acid metabolism in proliferating and differentiating colonic coils of man and neoplastic lesions of the colon 显示文摘 | Troncale F Mehta A Filipe M I | 1971 | Cancer Res1971，31，4： | 1 |
| 19 | Densities and viscosities of binary mixtures of babassu biodiesel + cotton seed or soybean biodiesel at different temperatures 显示文摘 | Carlos A N J Filipe X F Fabiano A N F | 2010 | Journal of Chemical & Engineering Data2010，55，11： | 1 |
| 20 | Exosomal glypican-1 is elevated in pancreatic cancer precursors and can signal genetic predisposition in the absence of endoscopic ultrasound abnormalities显示文摘BACKGROUND Individuals within specific risk groups for pancreatic ductal adenocarcinoma(PDAC)[mucinous cystic lesions(MCLs),hereditary risk(HR),and new-late onset diabetes mellitus(NLOD)]represent an opportunity for early cancer detection.Endoscopic ultrasound(EUS)is a premium image modality for PDAC screening and precursor lesion characterization.While no specific biomarker is currently clinically available for this purpose,glypican-1(GPC1)is overexpressed in the circulating exosomes(crExos)of patients with PDAC compared with healthy subjects or those harboring benign pancreatic diseases.AIM To evaluate the capacity of GPC1+crExos to identify individuals at higher risk within these specific groups,all characterized by EUS.METHODS This cross-sectional study with a prospective unicentric cohort included 88 subjects:40 patients with MCL,20 individuals with HR,and 20 patients with NLOD.A control group(CG)was submitted to EUS for other reasons than pancreatic pathology,with normal pancreas and absence of hereditary risk factors(n=8).The inclusion period was between October 2016 and January 2019,and the study was approved by the Ethics Committee of Centro Hospitalar Universitário de São João,Porto,Portugal.All patients provided written informed consent.EUS and blood tests for quantification of GPC1+crExos by flow cytometry and carbohydrate antigen 19-9(CA 19-9)levels by ELISA were performed in all subjects.EUS-guided tissue acquisition was done whenever necessary.For statistical analysis,SPSS®27.0(IBM Corp.,Armonk,NY,United States)version was used.All graphs were created using GraphPad Prism 7.00(GraphPad Software,San Diego,CA,United States).RESULTS Half of MCLs harbored worrisome features(WF)or high-risk stigmata(HRS).Pancreatic abnormalities were detected by EUS in 10.0%and 35.0%in HR and NLOD individuals,respectively,all considered non-malignant and“harmless.”Median levels of GPC1+crExos were statistically different:MCL[99.4%,interquartile range(IQR):94.9%-99.8%],HR(82.0%,IQR:28.9%-98.2%),NLOD(12.6%,IQR:5.2%-63.4%),and CG(16.2%,IQR:6.6%-20.1%)(P<0.0001).Median levels of CA 19-9 were within the normal range in all groups(standard clinical cut-off of 37 U/mL).Within HR,individuals with a positive history of cancer had higher median levels of GPC1+crExos(97.9%;IQR:61.7%-99.5%),compared to those without(59.7%;IQR:26.3%-96.4%),despite no statistical significance(P=0.21).Pancreatic cysts with WF/HRS were statistically associated with higher median levels of GPC1+crExos(99.6%;IQR:97.6%-99.8%)compared to those without(96.5%;IQR:81.3%-99.5%)(P=0.011),presenting an area under the receiver operating characteristic curve value of 0.723(sensitivity 75.0%and specificity 67.7%,using a cutoff of 98.5%;P=0.012).CONCLUSION GPC1+crExos may act as biomarker to support the diagnosis and stratification of PDAC precursor lesions,and in signaling individuals with genetic predisposition in the absence of EUS abnormalities. | Pedro Moutinho-Ribeiro Ines A Batista Sofia T Quintas Bárbara Adem Marco Silva Rui Morais Armando Peixoto Rosa Coelho Pedro Costa-Moreira Renato Medas Susana Lopes Filipe Vilas-Boas Manuela Baptista Diogo Dias-Silva Ana L Esteves Filipa Martins Joanne Lopes Helena Barroca Fátima Carneiro Guilherme Macedo Sonia A Melo | 2022 | World Journal of Gastroenterology2022，28，31： | 0 |
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