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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria显示文摘 | Bruno Dubois Howard H Feldman Claudia Jacova Harald Hampel José Luis Molinuevo Kaj Blennow Steven T DeKosky Serge Gauthier Dennis Selkoe Randall Bateman Stefano Cappa Sebastian Crutch Sebastiaan Engelborghs Giovanni B Frisoni Nick C Fox Douglas Galasko Ma | 2014 | Lancet Neurology2014，，6： | 7 |
| 3 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 4 | Molecular dynamics simulations of a supercooled monatomic liquid and glass显示文摘 | Fox J R Andersen H C | | 0，，18： | 1 |
| 5 | An apparently new transmissible disease of cattle显示文摘 | OLAFSON P MAC C A FOX F H | 1946 | Cornell Vet1946，36，： | 1 |
| 6 | Pa rental atrial fibrillation as a risk factor for atrial fibril lation in offspring显示文摘 | FOX C X PARISE H DAGOSTINO R S | 2004 | JAMA2004，291，： | 1 |
| 7 | Experimental evolution of the genetic load and its implications for the genetic basis of inbreeding depression显示文摘 | Fox C W SCHEIBLY K L REED D H | 2008 | Evolution2008，62，9： | 1 |
| 8 | Hexagonal adaptive filtering on compound ultrasound images 显示文摘 | ORTIZ S H C TSUICHENG C FOX M D | 2011 | Engineering in Medicine and Biology Society2011，，： | 1 |
| 9 | Cell cycle dependent apoptosis and cell cycle blocks induced by hyperthermia in HL-60 cells显示文摘 | Lim C U Zhang Y Fox M H | 2006 | Int Hyperthermia2006，22，1： | 1 |
| 10 | Injection of MK-801 affects ocular dominance shifts more than visual activity显示文摘 | Daw NW Gordon B Fox KD Flavin H J Kirsch JD Beaver C J | 1999 | JNeurophysiol1999，81，1： | 1 |
| 11 | Probiotics in the prevention and treatment of diarrhea显示文摘 | FOX C H DANG G | 2004 | J Ahem Complement Med2004，10，60： | 1 |
| 12 | Probiotics in the prevention and treatment of diarrhea 显示文摘 | FOX C H DANG G | 2004 | J Altern Complement Med2004，10，60： | 1 |
| 13 | Plant-adapted green fluorescent protein is a versatile vital reporter for gene expression, protein localization and mitosis in the filamentous fungus, Aspergillus nidulans 显示文摘 | Fernandez-Abalos J M Fox H Pitt C | 1998 | Mol Microbiol1998，27，1： | 1 |
| 14 | 查看详情显示文摘 | Fox D J Velde H T Preza C O'Sullivan J A Smith W H Woolsey T A | | 0，，： | 1 |
| 15 | Altered kelp (Laminariales) phlorotannins and growth under elevated carbon dioxide and ultraviolet-B treatments can influence associated intertidal food webs显示文摘 | SWANSON A K FOX C H | 2007 | Global Change Biology2007，13，8： | 1 |
| 16 | Lymphoid pneumonitis in 50 adult patients infected with the human immunodeficiency virus: lymphocytic interstitial pneumonitis versus non-specific interstitial pneumonitis显示文摘 | Travis W D Fox C H Devaney K O | 1992 | Hum Pathol1992，23，： | 1 |
| 17 | Characteristic electrophoretic patterns of plasma proteins of orders of Amphibia and Reptilia显示文摘 | Fox W | 1956 | Science1956，124，22： | 1 |
| 18 | Oncologic and functional out-come following sacreetomy for sacral chordoma 显示文摘 | Hulen C A Temple H T Fox W P | 2006 | J Bone Joint Surg(Am)2006，88，7： | 1 |
| 19 | Opioid-receptor mRNA expression in the rat CNS:Anatomical and functional implications显示文摘 | Mansour A Fox C A Akil H | 1995 | Trends in Neurosciences1995，18，1： | 1 |
| 20 | Geographic variations in plasma proteins patterns of snakes显示文摘 | Fox W | 1958 | Proc Soc Exp Biol1958，98，： | 1 |
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