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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria显示文摘 | Bruno Dubois Howard H Feldman Claudia Jacova Harald Hampel José Luis Molinuevo Kaj Blennow Steven T DeKosky Serge Gauthier Dennis Selkoe Randall Bateman Stefano Cappa Sebastian Crutch Sebastiaan Engelborghs Giovanni B Frisoni Nick C Fox Douglas Galasko Ma | 2014 | Lancet Neurology2014，，6： | 7 |
| 3 | 快速眼动睡眠行为疾病是神经系统变性疾病的早期标志:一项描述性研究显示文摘快速眼动睡眠行为疾病是一种深眠状态,其特点是存在恶梦内容相关的行为举动及快速眼动睡眠时肌肉的失张力状态。快速眼动睡眠行为疾病可以是原发性或与某神经疾病相关,有资料显示部分患者的快速眼动睡眠行为疾病可能是神经变性疾病的首发症状。本文研究了原发性快速眼动睡眠行为疾病患者发生神经系统变性疾病的的频率和特点。 | Iranzo A Molinuevo JL Santamaria J | 2006 | 国际内科双语杂志(中英文)2006，6，8： | 2 |
| 4 | Early diagnosis of Alzheimer's disease : the prodromal and preclinical phase显示文摘 | Valls-Pedret C Molinuevo JL Rami L | 2010 | Rev Neurol2010，51，8： | 1 |
| 5 | Anam- mox for ammonia removal from pig manure effluents: Effect of organic matter content on process performance 显示文摘 | Molinuevo B Garcla M C Karakashev D | 2009 | Bioresource Technology2009，100，7： | 1 |
| 6 | Rapid -eye -move-ment Sleep behaviour disorder as an early marker for a neurode-generative disorder:a descriptive study 显示文摘 | Iranzo A Molinuevo JL Santamaria J | 2006 | Lancet Neurol2006，5，： | 1 |
| 7 | Anammox for ammonia removal from pig manure effluents: effect of organic matter content on process performance 显示文摘 | Molinuevo B Garcia M C Karakashev D | 2009 | Bioresource Technology2009，100，7： | 1 |
| 8 | Electroencephalographic slowing heralds mild cognitive impairment in idiopathic REM sleep behavior disorder显示文摘 | Iranzo A Isetta V Molinuevo JL | 2010 | Sleep Med2010，11，6： | 1 |
| 9 | Insulin-deficient diabetes-induced bone microarchitecture alterations are associated with a decrease in the osteogenic potential of bone marrow progenitor cells: Preventive effects of metformin显示文摘 | María José Tolosa Sara Rocío Chuguransky Claudia Sedlinsky León Schurman Antonio Desmond McCarthy María Silvina Molinuevo Ana María Cortizo | 2013 | Diabetes Research and Clinical Practice2013，，2： | 1 |
| 10 | Impact of lower urinarytract symptoms on quality of life using Functional Assessment CancerTherapy Scale显示文摘 | Batista-Miranda JE Molinuevo B Pardo Y | 2007 | Urology2007，69，2： | 1 |
| 11 | Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder:a descriptive study显示文摘 | Iranzo A Molinuevo JL Santamaria J | | 0，，07： | 1 |
| 12 | EFNS ‐ ENS / EAN Guideline on concomitant use of cholinesterase inhibitors and memantine in moderate to severe Alzheimer’s disease显示文摘 | R. Schmidt E. Hofer F. H. Bouwman K. Buerger C. Cordonnier T. Fladby D. Galimberti J. Georges M. T. Heneka J. Hort J. Laczó J. L Molinuevo J. T. O’Brien D. Religa P. Scheltens J. M. Schott S. Sorbi | 2015 | Eur J Neurol2015，，： | 1 |
| 13 | Metformin prevents anti-osteogenic in vivo and ex vivo effects of rosiglitazone in rats显示文摘 | Claudia Sedlinsky María Silvina Molinuevo Ana María Cortizo María José Tolosa Juan Ignacio Felice María Laura Sbaraglini Leon Schurman Antonio Desmond McCarthy | 2011 | European Journal of Pharmacology2011，，3： | 1 |
| 14 | Saxagliptin affects long-bone microarchitecture and decreases the osteogenic potential of bone marrow stromal cells显示文摘 | Sbaraglini ML Molinuevo MS Sedlinsky C | 2014 | Eur J Pharmacol2014，727，： | 1 |
| 15 | Rapid-eyemovement sleep behavior disorder as an early marker for a neurodegenerative disorder: a descriptive study显示文摘 | Iranzo A Molinuevo JL Santamaria J | 2006 | Lancet Neurol2006，5，7： | 1 |
| 16 | Rapid eye movement sleep behavior disorder as an early marker for a neurodegenerative disorder:a descriptive study显示文摘 | Iranzo A Molinuevo JL Santamaria J | | 0，，07： | 1 |
| 17 | Inter- operator reliability of live football match statistics from OPTA Sportsdata显示文摘 | LIU H HOPKINS W GOMEZ M A MOLINUEVO J S | 2013 | Int J Perfor Analy Sport2013，13，： | 1 |
| 18 | Rapid-eye-movement sleep behaviour disorder early in maker for a neurodegenerative disorder : a de- scriptive study显示文摘 | Iranzo A Molinuevo JL Santamaria J | 2006 | Lancet Neuro12006，5，7： | 1 |
| 19 | Central motor conduction time in patients with multifocal motor conduction block 显示文摘 | Molinuevo JL Cruz-Martinez A Graus F | 1999 | Muscle Nerve1999，22，7： | 1 |
| 20 | Central motor conduction time in patients with multifocal motor conduction block显示文摘 | Molinuevo JL Cruz-Martinez A Graus F | 1999 | Muscle Nerve1999，22，7： | 1 |
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