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| 1 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 2 | Correction or deafness in shaker-2 mice by anunconventional myosin in a BAC transgene显示文摘 | 9,Frank JP Robert AF Yehoash R | 1998 | Science1998，280，： | 1 |
| 3 | Epidemic profile of Shiga-toxin-producing Escherichia coli O101:H4 outbreak in Germany 显示文摘 | Frank C Werber D Cramer JP | 2011 | N Engl J Med2011，365，： | 1 |
| 4 | Integrated pest management of pest mole crickets with emphasis on the southeastern USA 显示文摘 | Frank JH Parkman JP | 1999 | Integrated Pest Management Reviews1999，4，： | 1 |
| 5 | Failures for disorders of syndromes; anterior cervical fixation deovaic by fixation of morscher screw, a biomechanic study显示文摘 | Frank JR Morges PV | 1994 | J Spine Disorder1994，7，2： | 1 |
| 6 | Cone - beam computed tomography for on -line image guidance of lung stereotactic radiotherapy: Loealisation, verification, and in- trafraction tumor position 显示文摘 | Purdie TG Bisonnette JP Franks K | 2007 | Int J Radiat Oncol Biol Phys2007，68，7： | 1 |
| 7 | Epidemic profile of Shiga-toxin-producing Escherichia coli O104:H4 outbreak in Germany 显示文摘 | Frank C Werber D Cramer JP | 2011 | N Engl J Med2011，365，19： | 1 |
| 8 | Epidemic profile of Shigatoxin-producing Escherichia coli O104:H4 outbreak in Germany显示文摘 | Frank C Werber D Gramer JP | 2011 | N Engl J Med2011，365，19： | 1 |
| 9 | Bad split during bilateral sagittal split osteotomy of the mandible with separators: a retrospec- tive study of 427 patients 显示文摘 | Mensink G Verweij JP Frank MD | 2013 | Br J Oral Maxillofac Surg2013，51，6： | 1 |
| 10 | Epidemic profile of Shiga-toxin-producing Escherichia coli O104:H4 outbreak in Germany显示文摘 | Frank C Werber D Cramer JP | 2011 | N Engl J Med2011，365，19： | 1 |
| 11 | Type III protein secretion is associated with death in lower respiratory and systemic Pseudomonas aeruginosa infections 显示文摘 | Roy-Burman A Savel RH Racine S Swanson BL Revadi- gar NS Fujimoto J Sawa T Frank DW Wiener-Kronish JP | 2001 | J Infect Dis2001，183，12： | 1 |
| 12 | TRPM2:a Calcium Influx Pathway Regulated by Oxidative Stress and the Novel Second Messenger ADP-ribose显示文摘 | FRANK JP KUHN IH ANDREAS L | 2005 | Pflugers Arch -Eur J Physiol(S0031-6768)2005，451，： | 1 |
| 13 | Active and passive immuni- zation with the Pseudomonas V antigen protects against type III intoxication and lung injury 显示文摘 | Sawa T Yahr TL Ohara M Kurahashi K Gropper MA Wiener-Kronish JP Frank DW | 1999 | Nat Med1999，5，4： | 1 |
| 14 | Costs of needle stick inju- ries and subsequent hepatitis and HIV infection 显示文摘 | Leigh JP Gillen M Franks P | 2007 | Curt Meal Res Opin2007，23，9： | 1 |
| 15 | Multiresidue Analysis of β2-Agonists in Human and Calf Urine Using Multimodal Solid-phase Extraction and High-Performance Liquid Chromatography with Electrochemical Detection显示文摘 | Koole A Bosman J Franke JP | 1999 | J Chromatogr B1999，726，1： | 1 |
| 16 | Anode biofilm transcriptomics reveals outer surface components essential for high density current production in Geobacter sulfurreducens fuel cells 显示文摘 | Nevin KP Kim BC Glaven RH Johnson JP Woodard TL Meth6 BA DiDonato Jr RJ Covalla SF Franks AE Liu A | 2009 | PLoS One2009，4，5： | 1 |
| 17 | Epidemic profile of Shiga-toxin-producing Eschierichia coli O104:H4 outbreak in Germany显示文摘 | Frank C Werber D Cramer JP | 2011 | N Engl J Med2011，365，19： | 1 |
| 18 | Sumoylation of the nucleocapsid protein of severe acute respiratory syndrome coronavirus显示文摘 | Li Frank Qisheng Xiao Han Tam JP | 2005 | FEBS Lett2005，579，： | 1 |
| 19 | Epidemic profile of Shiga- toxin-producing Escherichia coli O104 :H4 outbreak in Germany显示文摘 | Frank C Werber D Cramer JP | 2011 | N Engl J Med2011，365，19： | 1 |
| 20 | Amyloid beta protein and tau incerebrospinal fluid and plasma as biomarkers for dementia: a review of recent literature 显示文摘 | Frank fort SV Tulner LR van Campen JP | 2008 | Curr Clin Pharmacol2008，3，2： | 1 |
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