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1Evaluation of inflammatory activity in Crohn's disease and ulcerative colitis显示文摘Crohn's disease and ulcerative colitis evolve with a relapsing and remitting course.Determination of inflammatory state is crucial for the assessment of disease activity and for tailoring therapy.However,no simple diagnostic test for monitoring intestinal inflammation is available.Noninvasive markers give only indirect assessments of disease activity.Histopathological or endoscopical examinations accurately assess inflammatory activity,but they are invasive,time consuming and expensive and therefore are unsuitable for routine use.Imaging procedures are not applicable for ulcerative colitis.The usefulness of ultrasound and Doppler imag-ing in assessing disease activity is still a matter of discussion for Crohn's disease,and an increased interest in computed tomography enterograph (CTE) has been seen,mainly because it can delineate the extent and severity of bowel wall inflammation,besides detecting extraluminal findings.Until now,the available data concerning the accuracy of magnetic resonance enterography in detecting disease activity is less than CTE.Due to this,clinical activity indices are still commonly used for both diseases.Eduardo Garcia Vilela Henrique Osvaldo da Gama Torres Fabiana Paiva Martins Maria de Lourdes de Abreu Ferrari Marcella Menezes Andrade Aloísio Sales da Cunha 2012World Journal of Gastroenterology2012,18,9:23
2Oxidative stress:New insights on the association of nonalcoholic fatty liver disease and atherosclerosis显示文摘Non-alcoholic fatty liver disease(NAFLD) represents the most common and emerging chronic liver disease worldwide. It includes a wide spectrum of liver diseasesranging from simple fatty liver to non-alcoholic steatohepatitis(NASH),which may progress to fibrosis and more severe liver complications such as cirrhosis,hepatocellular carcinoma and liver mortality. NAFLD is strongly associated with obesity,insulin resistance,hypertension,and dyslipidaemia,and is now regarded as the liver manifestation of the metabolic syndrome. The increased mortality of patients with NAFLD is primarily a result of cardiovascular disease and,to a lesser extent,to liver related diseases. Increased oxidative stress has been reported in both patients with NAFLD and patient with cardiovascular risk factors. Thus,oxidative stress represents a shared pathophysiological disorder between the two conditions. Several therapeutic strategies targeting oxidative stress reduction in patients with NAFLD have been proposed,with conflicting results. In particular,vitamin E supplementation has been suggested for the treatment of non-diabetic,non-cirrhotic adults with active NASH,although this recommendation is based only on the results of a single randomized controlled trial. Other antioxidant treatments suggested are resveratrol,silybin,L-carnitine and pentoxiphylline. No trial so far,has evaluated the cardiovascular effects of antioxidant treatment in patients with NAFLD. New,large-scale studies including as end-point also the assessment of the atherosclerosis markers are needed.Licia Polimeni Maria Del Ben Francesco Baratta Ludovica Perri Fabiana Albanese Daniele Pastori Francesco Violi Francesco Angelico 2015World Journal of Hepatology2015,7,10:23
3关于孤立特发性中枢性性腺功能低下(ICH)遗传病因的新发现显示文摘特发性低促性腺激素性性功能减退症(IHH)是一种罕见的疾病,它的病症表现为青春期的推迟或者缺失,以及(或者)不育症。这些病症是由于促性腺激素释放激素(GnRH)的作用未能对正常的垂体.性腺轴产生足够的刺激。由于罹患该病的患者体内的促卯泡激素(FSH)和黄体生成素(LH)的水平偏低或正常,所以采用孤立特发性中枢性性腺功能低下(ICH)这一术语定义该疾病可能更为合适。该疾病应区别于伴有其它垂体缺陷的中枢性性腺功能减退。孤立特发性中枢性性腺功能低下的发病机制比较复杂,且在男性中的发病率比中枢性性腺功能减退多5倍。大部分情况下,该病的患病人群比较分散,但也曾经报道过几例家族病例。这一发现加上其它很多致病基因突变的调查,以及一些基因敲除模型的出现,证明了该疾病的发病可能有一个强大的遗传学因素存在。孤立特发性中枢性性腺功能低下可能与一些包含锇缺乏在内的形态遗传学异常有关联,而锇缺乏与孤立特发性中枢性性腺功能低下构成了卡尔曼氏综合症(KS)的主要病征。在全部的孤立特发性中枢性性腺功能低下病例中,卡尔曼氏综合症约占40%,也被视作一个特殊的患者子群体。然而,经过对患有孤立的锇缺陷或者卡尔曼氏综合症(KS)亦或孤立特发性中枢性性腺功能低下的包含亲戚在内的几个家族谱系内部的病患的调查,证明孤立特发性中枢性性腺功能低下是一种复杂的遗传性疾病,它具有复杂多样的表征以及显性。由此得出,不管是多个基因变异还是环境因素或者核外遗传的变化都有可能导致复杂多样的病征。本文综述了己知的、与孤立特发性中枢性性腺功能低下的发病机制相关的遗传机制,并且对由意大利孤立特发性中枢性性腺功能低下网络合作中心所收集的227例病例作出临床概述。Marco Bonomi Domenico Vladimiro Libri Fabiana Guizzardi Elena Guarducci Elisabetta Maiolo Elisa Pignatti Roberta Asci Luca Persani 2012Asian Journal of Andrology2012,14,1:10
4Identification of four novel DC-SIGN ligands on Mycobacterium bovis BCG显示文摘Dendritic-cell-specific intercellular adhesion molecule-3-grabbing non-integrin(DC-SIGN;CD209)has an important role in mediating adherence of Mycobacteria species,including M.tuberculosis and M.bovis BCG to human dendritic cells and macrophages,in which these bacteria can survive intracellularly.DC-SIGN is a C-type lectin,and interactions with mycobacterial cells are believed to occur via mannosylated structures on the mycobacterial surface.Recent studies suggest more varied modes of binding to multiple mycobacterial ligands.Here we identify,by affinity chromatography and mass-spectrometry,four novel ligands of M.bovis BCG that bind to DC-SIGN.The novel ligands are chaperone protein DnaK,60 kDa chaperonin-1(Cpn60.1),glyceraldehyde-3 phosphate dehydrogenase(GAPDH)and lipoprotein lprG.Other published work strongly suggests that these are on the cell surface.Of these ligands,lprG appears to bind DC-SIGN via typical proteinglycan interactions,but DnaK and Cpn60.1 binding do not show evidence of carbohydrate-dependent interactions.LprG was also identified as a ligand for DC-SIGNR(L-SIGN;CD299)and the M.tuberculosis orthologue of lprG has been found previously to interact with human toll-like receptor 2.Collectively,these findings offer new targets for combating mycobacterial adhesion and within-host survival,and reinforce the role of DCSIGN as an important host ligand in mycobacterial infection.Maria V.Carroll Robert B.Sim Fabiana Bigi Anne Jäkel Robin Antrobus Daniel A.Mitchell 2010Protein & Cell2010,1,9:7
5Hepatitis B and C virus reactivation in immunosuppressed patients with inflammatory bowel disease显示文摘In recent years,a number of case reports and clinical studies have highlighted the risk of hepatitis B and C virus reactivation in patients with inflammatory bowel disease who are treated with immunosuppressive drugs.The cases of viral hepatitis reactivation that have been reported are characterized by a wide range of clinical manifestations,from viremia without clinically relevant manifestations to fulminant life-threatening hepatitis.The development and dissemination of biological immunosuppressive drugs have led to a significant increase in the number of reports of interest to physicians in a variety of clinical settings.On this topic,there have been a number of published guidelines and reviews that have collected the available evidence,providing recommendations on prophylactic and therapeutic strategies and methods for monitoring patients at risk.However,it should be noted that,to date,very few clinical studies have been published,and most of the recommendations have been borrowed from otherclinical settings.The published studies are mostly retrospective and are based on very heterogeneous populations,using different therapeutic and prophylactic regimens and obtaining conflicting results.Thus,it seems clear that it is desirable to concentrate our efforts on prospective studies,not conducting further reviews of the literature in the continued absence of new evidence.Stefano Sansone Maria Guarino Fabiana Castiglione Antonio Rispo Francesco Auriemma Ilaria Loperto Matilde Rea Nicola Caporaso Filomena Morisco 2014World Journal of Gastroenterology2014,20,13:6
6Transcranial direct current stimulation in psychiatric disorders显示文摘The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally,we provide an overview of t DCS use in cognitive enhancement as well as a discussion regarding its clinical use and regulatory and ethical issues. Although many promising results regarding t DCS efficacy were described, the total number of studies is still low, highlighting the need of further studies aiming to replicate these findings in larger samples as to provide a definite picture regarding t DCS efficacy in psychiatry.Gabriel Tortella Roberta Casati Luana V M Aparicio Antonio Mantovani Natasha Senco Giordano D’Urso Jerome Brunelin Fabiana Guarienti Priscila Mara Lorencini Selingardi Débora Muszkat Bernardo de Sampaio Pereira Junior Leandro Valiengo Adriano H Moffa Marcel Simis Lucas Borrione André R Brunoni 2015World Journal of Psychiatry2015,5,1:6
7Management and control applications in Agriculture domain via a Future Internet Businessto- Business platform显示文摘The Agriculture business domain,as a vital part of the overall supply chain,is expected to highly evolve in the upcoming years via the developments,which are taking place on the side of the Future Internet.This paper presents a novel Business-to-Business collaboration platform from the agri-food sector perspective,which aims to facilitate the collaboration of numerous stakeholders belonging to associated business domains,in an effective and flexible manner.The contemporary B2B collaboration schemes already place the requirements for swift deployment of cloud applications,capable of both integrating diverse legacy systems,as well as developing in a rapid way new services and systems,which will be able to instantly communicate and provide complete,'farm-to-fork'solutions for farmers,agrifood and logistics service providers,ICT companies,end-product producers,etc.To this end,this conceptual paper describes how these requirements are addressed via the FIspace B2B platform,focusing on the Greenhouse Management&Control scenarios.Sokratis Barmpounakis Alexandros Kaloxylos Aggelos Groumas Lampros Katsikas Vasileios Sarris Konstantina Dimtsa Fabiana Fournier Eleni Antoniou Nancy Alonistioti Sjaak Wolfert 2015Information Processing in Agriculture2015,2,1:4
8Bcl-2 down modulation in WEHI-3B/CTRES cells resistant to Cholera Toxin(CT)-induced apoptosis显示文摘细胞生长和增长上的霍乱毒素(CT ) 的不同效果可以在细胞膜和触发的不同信号 transduction 机制取决于 ganglioside 受体的类型,但是其它与药抵抗机制有关工作不能被排除。CT 处理在上的效果“在 vitro ”, clonogenicity,人口双倍工资(太平洋夏季时间) , apoptosis, PKA 激活和 Bax 和 Bcl-2 表示在 WEHI-3B 房间线和它的 CT 抵抗的潜水艇克隆(WEHI-3B/CTRES ) 被评估。在 WEHI-3B 父母房间, CT 导致的营地的戏剧的累积与 PKA 激活相关很好,增加的太平洋夏季时间价值, clonogenicity 和 apoptosis 的抑制。H-89 处理由 CT 禁止了 PKA 激活但是没保护房间免受 apoptosis 和生长抑制的伤害。在 WEHI-3B/CTRES,营地的重要 CT 依赖的累积都没随 PKA 活动和太平洋夏季时间的任何增加发生。在 CT 抵抗房间(WEHI-3B/CTRES ) , Bcl-2 表示低由 CT 或药处理调整了(例如, ciprofloxacin, CPX ) 尽管这些房间被保护免受 CT 依赖的 apoptosis 的伤害然而并非从导致药的 apoptosis。不同地,从另外的房间,模型描述了,在 Bcl-2 的规定下面被证明在营地累积和 PKA 激活上独立。我们的观察在 WEHI-3B 细胞生长的抑制支持营地依赖者 kinase (PKA ) 的含意并且建议在 WEHI-3B/CTRES, Bcl-2 表示能被 CT 当营地累积不在时调制。另外,在许多的考虑,矛盾的数据在文学报导了,我们的房间模型(有到 CT 和 CPX 的不同使不交叉的特定的抵抗的一个敏感父母房间种类和二克隆)为更好调查在 CT 信号 transduction 机制和 Bcl-2 表示和函数之间的关系提供一个新、有趣的工具。Augusto Pessina Cristina Croera Nicoletta Savalli Arianna Bonomi Loredana Cavicchini Elisa Turlizzi Fabiana Guizzardi Lucia Guido Laura Daprai Maria GraziaNeri 2006Cell Research2006,16,3:4
9The expression of efflux and uptake transporters are regulated by statins in Caco-2 and HepG2 cells显示文摘Alice Cristina RODRIGUES Rui CURI Fabiana Dalla Vecchia GENVIGIR Mario Hiroyuki HIRATA Rosario Dominguez Crespo HIRATA 2009Acta Pharmacologica Sinica2009,30,7:4
10Subcellular localization of alpha-synuclein aggregates and their interaction with membranes显示文摘For more than a decade numerous evidence has been reported on the mechanisms of toxicity of α-synuclein(αS) oligomers and aggregates in α-synucleinopathies.These species were thought to form freely in the cytoplasm but recent reports of αS multimer conformations when bound to synaptic vesicles in physiological conditions,have raised the question about where αS aggregation initiates.In this review we focus on recent literature regarding the impact on membrane binding and subcellular localization of αS toxic species to understand how regular cellular function of αS contributes to pathology.Notably αS has been reported to mainly associate with specific membranes in neurons such as those of synaptic vesicles,ER/Golgi and the mitochondria,while toxic species of αS have been shown to inhibit,among others,neurotransmission,protein trafficking and mitochondrial function.Strategies interfering with αS membrane binding have shown to improve αS-driven toxicity in worms and in mice.Thus,a selective membrane binding that would result in a specific subcellular localization could be the key to understand how aggregation and pathology evolves,pointing out to αS functions that are primarily affected before onset of irreversible damage.Fabiana Miraglia Alessio Ricci Lucia Rota Emanuela Colla 2018Neural Regeneration Research2018,13,7:4
11Induced pluripotent stem cells throughout the animal kingdom:Availability and applications显示文摘Up until the mid 2000s, the capacity to generate every cell of an organism was exclusive to embryonic stem cells. In 2006, researchers Takahashi and Yamanaka developed an alternative method of generating embryonic-like stem cells from adult cells, which they coined induced pluripotent stem cells (iPSCs). Such iPSCs possess most of the advantages of embryonic stem cells without the ethical stigma associated with derivation of the latter. The possibility of generating “custom-made” pluripotent cells, ideal for patient-specific disease models, alongside their possible applications in regenerative medicine and reproduction, has drawn a lot of attention to the field with numbers of iPSC studies published growing exponentially. IPSCs have now been generated for a wide variety of species, including but not limited to, mouse, human, primate, wild felines, bovines, equines, birds and rodents, some of which still lack well-established embryonic stem cell lines. The paucity of robust characterization of some of these iPSC lines as well as the residual expression of transgenes involved in the reprogramming process still hampers the use of such cells in species preservation or medical research, underscoring the requirement for further investigations. Here, we provide an extensive overview of iPSC generated from a broad range of animal species including their potential applications and limitations.Lais Vicari de Figueiredo Pessoa Fabiana Fernandes Bressan Kristine Karla Freude 2019World Journal of Stem Cells2019,11,8:4
12Unreliability of aortic size index to predict risk of aortic dissection in a patient with Turner syndrome显示文摘Aortic size index(ASI) has been proposed as a reliable criterion to predict risk for aortic dissection in Turner syndrome with significant thresholds of 20-25 mm/m2. We report a case of aortic arch dissection in a patient with Turner syndrome who, from the ASI thresholds proposed, was deemed to be at low risk of aortic dis-section or rupture and was not eligible for prophylactic surgery. This case report strongly supports careful monitoring and surgical evaluation even when the ASI is < 20 mm/m2 if other significant risk factors are present.Jan Nijs Sandro Gelsomino Fabiana Lucà Orlando Parise Jos G Maessen Mark La Meir 2014World Journal of Cardiology2014,6,5:3
13Colonic duplication in an adult mimicking a tumor of pancreas显示文摘Duplications of the alimentary tract are uncommon congenital malformations that can present diagnostic difficulties. We report a rare case of a cystic colonic duplication in a female adult. Preoperative investigations were suggestive of pancreatic tumor. The diagnosis was established based on the histopathological examination of the resected specimen. We concluded that, though uncommon, intestinal duplication should be considered in differential diagnosis of abdominal mass.Fabiana Pirani Carneiro Maria de Nazareth Sobreira Ana Emília B de Azevedo Andréa Pedrosa Ribeiro Alves Karina Martins Campos 2008World Journal of Gastroenterology2008,14,6:3
14Celiac disease: Alternatives to a gluten free diet显示文摘Celiac disease is a chronic inflammatory disorder of the small intestine caused by the ingestion of gluten or related rye and barley proteins. At present, the only available treatment is a strict gluten-exclusion diet. However, recent understanding of the molecular basis for this disorder has improved and enabled the identif ication of targets for new therapies. This article aims to critically summarize these recent studies.Fabiana Zingone Pietro Capone Carolina Ciacci 2010World Journal of Gastrointestinal Pharmacology and Therapeutics2010,1,1:3
15Physiological Effect of Kinetin on the Photosynthetic Apparatus and Antioxidant Enzymes Activities During Production of Anthurium显示文摘The results observed in the literature raise the hypothesis according to which cytokinin plays important roles in photosynthetic metabolisms and antioxidant enzymes. Thus, the study aimed to evaluate the effect of foliar application of the isolated cytokinin kinetin at the production cycle, seeking to analyze its effects on enzyme activity and photosynthetic parameters. The plants treated with CK presented reduction of leaf CO_2 assimilation rate(Pn) and stomatal conductance(Gs), while that transpiration rate(Tr) was unaffected. The internal CO_2 concentrations decreased with the increase in cytokinin levels, but were maintained under CK 50 mg·L^(-1). The plants treated with CK 75 mg·L^(-1) was verified higher carboxylation efficiency(Pn/Ci), which was associated to values of CO_2 assimilation and transpiration unaltered. Apparent electron transport rate showed variations in the concentration of 25 mg·L^(-1). Considering the study of enzyme activity, on the other hand, it cannot be stated that kinetin has an effective action in delaying oxidative damage. It presents mixed results, since an efficiency in the application of cytokinin was not observed, presenting induction levels of ascorbate peroxidase activity. Thus, further research is needed to determine more precisely the effects of kinetin on gas exchange and antioxidant enzymes in anthurium plants.de MOURA Fabiana B. VIEIRA Marcos R. da S. SIMOES Adriano do N. FERREIRA-SILVA Sérgio L. de SOUZA Carlos A.V. de SOUZA Eduardo S. da ROCHA Alexandre T. da SILVA Luzia F. JUNIOR Miguel A. 2018Horticultural Plant Journal2018,4,5:3
16Association between thrombomodulin and high mobility group box 1 in sepsis patients显示文摘BACKGROUND High mobility group box 1(HMGB1)has been studied as a molecule associated with severe outcomes in sepsis and thrombomodulin(TM)seems to decrease HMGB1 activity.AIM To investigate the role of the thrombomodulin/high mobility group box 1(T/H)ratio in patients with sepsis and their association with their clinic,testing the hypothesis that higher ratios are associated with better outcomes.METHODS Twenty patients diagnosed with sepsis or septic shock,according to the 2016 criteria sepsis and septic shock(Sepsis-3),were studied.Patients were followed until they left the intensive care unit or until they achieved 28 d of hospitalization(D28).The following clinical outcomes were observed:Sequential Organ Failure Assessment(SOFA)score;Need for mechanical pulmonary ventilation;Presence of septic shock;Occurrence of sepsis-induced coagulopathy;Need for renal replacement therapy(RRT);and Death.RESULTS The results showed that patients with SOFA scores greater than or equal to 12 points had higher serum levels of TM:76.41±29.21 pg/mL vs 37.41±22.55 pg/mL among those whose SOFA scores were less than 12 points,P=0.003.The T/H ratio was also higher in patients whose SOFA scores were greater than or equal to 12 points,P=0.001.The T/H ratio was,on average,three times higher in patients in need of RRT(0.38±0.14 vs 0.11±0.09),P<0.001.CONCLUSION Higher serum levels of TM and,therefore,higher T/H ratio in the first 24 h after the diagnosis of sepsis were associated with more severe disease and the need for renal replacement therapy,while those with better clinical outcomes and those who were discharged before D28 showed a tendency for lower T/H ratio values.Adriana Teixeira Rodrigues Julia Teixeira Rodrigues Carolina Teixeira Rodrigues Caroline Maria de Oliveira Volpe Fabiana Rocha-Silva Jose Augusto Nogueira-Machado Luiz Ronaldo Alberti 2020World Journal of Critical Care Medicine2020,9,4:3
17Fluoroquinolone-based protocols for eradication of Helicobacter pylori显示文摘Helicobacter pylori(H. pylori) is a widespread pathogen infecting about 40% of people living in urban areas and over 90% of people living in the developing regions of the world. H. pylori is well-documented as the main factor in the pathogenesis of peptic ulcer disease, chronic gastritis, and gastric malignancies such as cancer and mucosa-associated lymphoid tissuelymphoma; hence, its eradication is strongly recommended. the Maastricht Ⅳ consensus, which focused on the management of H. pylori infection, set important new strategies in terms of treatment approaches, particularly with regards to first- and second-line treatment protocols and led to improved knowledge and understanding of H. pylori resistance to antibiotics. In recent years, various fluoroquinolone-based protocols, mainly including levofloxacin, have been proposed and effectively tested at all therapeutic lines for H. pylori eradication. the aim of the present paper is to review the scientific literature focused on the use of fluoroquinolones in eradicating H. pylori.Antonio Rispo Pietro Capone fabiana Castiglione Luigi Pasquale Matilde Rea Nicola Caporaso 2014World Journal of Gastroenterology2014,20,27:3
18Occult neural foraminal stenosis caused by association between disc degeneration and facet joint osteoarthritis: demonstration with dedicated upright MRI system显示文摘Alessandra Splendiani Fabiana Ferrari Antonio Barile Carlo Masciocchi Massimo Gallucci 2014La radiologia medica2014,,3:2
19Extramedullary plasmocytoma associated with a massive deposit of amyloid in the duodenum显示文摘We report a rare case of extramedullary plasmocytoma associated with a massive deposit of amyloid in the duodenum.A 72-year-old Japanese man was admitted to our hospital presenting with a 3-mo history of epigastric pain, vomiting and weight loss.On computed tomography(CT) a wall thickening of the fourth part of the duodenum was observed.Multiple biopsies obtained from the lesion showed inflltration of plasma cells and lymphocytes, but they were not conclusive.The patient underwent resection of the lesion and, on histopathological examination, the lesion consisted of a dense and diffuse inflltrate of plasma cells and a few admixed lymphocytes with reactive follicles extending to the muscular propria.An extensive deposition of amyloid was also observed.Immunohistochemical stains revealed that a few plasmacytoid cells showed λ light chain staining, though most were κ light chain positive.These cells also were positive for CD138 and CD56 but negative for CD20 and CD79.The flndings were consistent with extramedullary plasmocytomaassociated with a massive deposit of amyloid in duodenum.A subsequent workup for multiple myeloma was completely negative.The patient showed no signs of local recurrence or dissemination of the disease after 12 mo follow-up.Because of the association of plasmocytoma and amyloidosis, the patient must be followed up because of the possible systemic involvement of the neoplasm and amyloidosis in future.Fabiana Pirani Carneiro Maria de Nazareth Machado Sobreira Lívia Bravo Maia Alesso Cervantes Sartorelli Luiz Eduardo de Almeida Prado Franceschi Mauro Brito Brando Bárbara Wosnjuk Calaca Fernando Silva Lustosa Joo Vieira Lopes 2009World Journal of Gastroenterology2009,15,28:2
20"Malignant" right coronary artery presenting as an ST-segment elevation myocardial infarction -a case report显示文摘Cherisse Baldeo Karan Seegobin Dmitry Yaranov Fabiana Rollini 2018Journal of Geriatric Cardiology2018,15,6:2
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