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| 1 | Laparoscopic approach to Meckel's diverticulum显示文摘AIM: To retrospective review the laparoscopic management of Meckel Diverticulum(MD) in two Italian Pediatric Surgery Centers.METHODS: Between January 2002 and December 2012, 19 trans-umbilical laparoscopic-assisted(TULA) procedures were performed for suspected MD. The children were hospitalized for gastrointestinal bleeding and/or recurrent abdominal pain. Median age at diagnosis was 5.4 years(range 6 mo-15 years). The study included 15 boys and 4 girls. All patients underwent clinical examination, routine laboratory tests, abdominal ultrasound and technetium-99m pertechnetate scan, and patients with bleeding underwent gastrointestinal endoscopy. The abdominal exploration was performed with a 10 mm operative laparoscope. Pneumoperitoneum was establishedbased on the body weight. Systematic overview of the peritoneal cavity allowed the ileum to be grasped with an atraumatic instrument. The complete exploration and surgical treatment of MD were performed extracorporeally, after intestinal exteriorization through the umbilicus. All patients' demographics, main clinical features, diagnostic investigations, operative time, histopathology reports, conversion rate, hospital stay and complications were registered and analyzed.RESULTS: MD was identified in 17 patients, while 1 had an ileal duplication and 1 a jejunal hemangioma. Fifteen patients had painless intestinal bleeding, while 4 had recurrent abdominal pain and exhibited cyst like structures in an ultrasound study. Eleven patients had a positive technetium-99m pertechnetate scan. In the patients with bleeding, gastrointestinal endoscopy did not name the source of hemorrhage. All patients were subjected to a TULA surgical procedure. An intestinal resection/anastomosis was performed in 14 patients, while 4 had a wedge resection of the diverticulum and 1 underwent stapling diverticulectomy. All surgical procedures were performed without conversion to open laparotomy. Mean operative time was 75 min(range 40-115 min). No major surgical complications were recorded. The median hospital stay was 5-7 d(range 4-13 d). All patients are asymptomatic at a median follow up of 4, 5 years(range 10 mo-10 years).CONCLUSION: Trans-umbilical laparoscopic-assisted Meckel's diverticulectomy is safe and effective in the treatment of MD, with excellent results. | Alfonso Papparella Fabiano Nino Carmine Noviello Antonio Marte Pio Parmeggiani Ascanio Martino Giovanni Cobellis | 2014 | World Journal of Gastroenterology2014，20，25： | 7 |
| 2 | pRB expression in esophageal mucosa of individuals at high risk for squamous cell carcinoma of the esophagus显示文摘AIM: To investigate the pRb expression in a large group of patients with history of chronic exposure to the main risk factors for development of squamous cell carcinoma of the esophagus. METHODS: One hundred and seventy asymptomatic individuals at high risk for esophageal squamous cell carcinoma (consumption of more than 80 g of ethanol and 10 cigarettes/d for at least 10 years) underwent upper gastrointestinal endoscopy with biopsies of the esophageal mucosa. As a control group, specimens of esophageal mucosa obtained from 20 healthy subjects were also studied. Immunohistochemical assessment of the tissues was performed using a monoclonal antibody anti-pRB protein. RESULTS: Absence of the pRB staining, indicating loss of RB function, was observed in 33 (19.4%) of the individuals at risk for esophageal cancer, but in none of the healthy controls (P < 0.02). Loss of pRb expression increased in a stepwise fashion according to the severity of the histological findings (P < 0.005): normal mucosa (11/97 or 11.3%), chronic esophagitis (17/60 or 28.3%), low-grade dysplasia (3/10 or 30%), high-grade dysplasia 1/2 or 50%) and squamous cell carcinoma (1/1 or 100%). CONCLUSION: Our findings suggest that abnormal expression of the pRB protein may be implicated in the process of esophageal carcinogenesis. Additional studies are warranted to define the role of the pRBprotein as a biomarker for development of esophageal squamous cell carcinoma in individuals at high risk for this malignancy. | Simone S Contu Paulo C Contu Daniel C Damin Renato B Fagundes Fabiano Bevilacqua Aline S Rosa Joo C Prolla Luis F Moreira | 2007 | World Journal of Gastroenterology2007，13，11： | 5 |
| 3 | Combined therapy with bevacizumab and photodynamic therapy for myopic choroidal neovascularization: A oneyear follow-up controlled study显示文摘AIM:To evaluate the efficacy and safety of a combined treatment for myopic choroidal neovascularization(CNV)using photodynamic therapy(PDT)and intravitreal bevacizumab and to compare it with intravitreal bevacizumab monotherapy.METHODS:Thirty-four eyes with angiographic evidence of myopic CNV were randomly divided into two groups:17 were treated with one intravitreal bevacizumab injection(1.25 mg)and low-fluence-rate PDT within seven days of the injection(Group A).The other 17 received monotherapy with bevacizumab injections(Group B).Clinical evidence of complications,best corrected visual acuity(BCVA)and fluorescein leakage were evaluated.BCVA and optical coherence tomography(OCT)were evaluated monthly.The timepoints follow-up was established at 6 and 12mo.All patients were retreated following a PRN protocol.RESULTS:A total of 34 eyes of 34 patients(26 women and 8 men)with a mean age of 62.35 years were included.In Group A(17 eyes)the mean BCVA increased from 0.55±0.13 logMAR before the treatment to 0.40±0.09 logMAR at the 12mo follow-up(P<0.01).In Group B(17 eyes)the mean BCVA increased from 0.60±0.11 logMAR before the treatment to 0.55±0.12 logMAR at the 12mo follow-up(P<0.01).There was no statistically significant difference between the two groups in terms of LogMar visual acuity.In Group A the mean number of combined treatments was 1.8±0.11 per patient;in Group B the mean number of intravitreal bevacizumab injections was3.1±0.08 per patient.The number of treatments was significantly fewer in Group A(P<0.01).No local or systemic side effects occurred among any of the patients treated in this study.CONCLUSION:The combination of anti-angiogenic injections and PDT appears to be a safe and effective option for myopic CNV treatment and allows for a significant reduction of intravitreal injections. | Sandro Saviano Rita Piermarocchi Pia E.Leon Alessandro Mangogna Andrea Zanei Fabiano Cavarzeran Sc Daniele Tognetto | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 5 |
| 4 | Green tea polyphenols inhibit testosterone production in rat Leydig cells显示文摘这研究调查了绿茶摘录(GTE ) 和它的多酚的尖锐效果成分,(-)-epigallocatechin-3-gallate (EGCG ) 和(-)-epicatechin (EC ) ,在由在 vitro 的老鼠 Leydig 房间的基础、刺激的睾丸激素生产上。在一个 Percoll 坡度净化的 Leydig 房间与 GTE, EGCG 或 EC 和睾丸激素先锋 androstenedione 为 3 h 被孵化,当面或任何一个蛋白质 kinase A (PKA ) 的缺席或蛋白质 kinase C (PKC ) 使活跃之物。效果的可逆性被 pretreating 房间与 GTE 或 EGCG 为 15 min 学习,允许他们为 1 h 恢复并且为有人的 chorionic 的 2 h 质问他们 gonadotropin (hCG ) , luteinizing 荷尔蒙释放荷尔蒙(LHRH ) , 22 (R)-hydroxycholesterol 或 androstenedione。GTE 和 EGCG,然而并非 EC,禁止了基础、刺激 kinase 的睾丸激素生产。在预告的处理条件下面, hCG/LHRH-stimulated 或 22 (R)-hydroxycholesterol-induced 睾丸激素生产上的 GTE/EGCG 的更高的集中的禁止的效果被维持,而支持 androstenedione 的睾丸激素生产回来了控制层次。在 GTE/EGCG 的更低的集中, 22 (R)-hydroxycholesterol-supported 睾丸激素生产上的这些多酚的禁止的效果被颠倒。GTE 的禁止的效果可以被它一个 gallate 组的主要部件, EGCG,和存在的行动在它的结构解释在禁止睾丸激素生产为它的高功效似乎重要。位于 GTE 和 EGCG 的效果下面的机制包含表明 P450 方面链劈开酶和 17-hydroxysteroid 脱氢酶功能的小径,以及抑制的 PKA/PKC 的抑制。 | Marina S. Figueiroa Juliany S. B. Cesar Vieira Disleide S. Leite Ruben C. O. Andrade Filho Fabiano Ferreira Patricia S. Gouveia Daniel P. Udrisar Maria I. Wanderley | 2009 | Asian Journal of Andrology2009，11，3： | 4 |
| 5 | Factors that Affect Pellet Quality: A Review显示文摘 | Keysuke Muramatsu Andreia Massuquetto Fabiano Dahlke Alex Maiorka | 2015 | Journal of Agricultural Science and Technology(A)2015，5，9： | 4 |
| 6 | Beneficial effects of adenosine triphosphate-sensitive K^+ channel opener on liver ischemia/reperfusion injury显示文摘AIM:To investigate the effect of diazoxide administration on liver ischemia/reperfusion injury.METHODS:Wistar male rats underwent partial liver ischemia performed by clamping the pedicle from the medium and left anterior lateral segments for 1 h under mechanical ventilation.They were divided into 3 groups:Control Group,rats submitted to liver manipulation,Saline Group,rats received saline,and Diazoxide Group,rats received intravenous injection diazoxide(3.5 mg/kg) 15 min before liver reperfusion.4 h and 24 h after reperfusion,blood was collected for determination of aspartate transaminase(AST),alanine transaminase(ALT),tumor necrosis factor(TNF-α),interleukin-6(IL-6),interleukin-10(IL-10),nitrite/nitrate,creatinine and tumor growth factor-β1(TGF-β1).Liver tissues were assembled for mitochondrial oxidation and phosphorylation,malondialdehyde(MDA) content,and histologic analysis.Pulmonary vascular permeability and myeloperoxidase(MPO) were also determined.RESULTS:Four hours after reperfusion the diazoxide group presented with significant reduction of AST(2009 ± 257 U/L vs 3523 ± 424 U/L,P = 0.005); ALT(1794 ± 295 U/L vs 3316 ± 413 U/L,P = 0.005); TNF-α(17 ± 9 pg/mL vs 152 ± 43 pg/mL,P = 0.013; IL-6(62 ± 18 pg/mL vs 281 ± 92 pg/mL); IL-10(40 ± 9 pg/mL vs 78 ± 10 pg/mL P = 0.03),and nitrite/nitrate(3.8 ± 0.9 μmol/L vs 10.2 ± 2.4 μmol/L,P = 0.025) when compared to the saline group.A significant reduction in liver mitochondrial dysfunction was observed in the diazoxide group compared to the saline group(P < 0.05).No differences in liver MDA content,serum creatinine,pulmonary vascular permeability and MPO activity were observed between groups.Twenty four hours after reperfusion the diazoxide group showed a reduction of AST(495 ± 78 U/L vs 978 ± 192 U/L,P = 0.032); ALT(335 ± 59 U/L vs 742 ± 182 U/L,P = 0.048),and TGF-β1(11 ± 1 ng/mL vs 17 ± 0.5 ng/mL,P = 0.004) serum levels when compared to the saline group.The control group did not present alterations when compared to the diazoxide and saline groups.CONCLUSION:Diazoxide maintains liver mitochondrial function,increases liver tolerance to ischemia/reperfusion injury,and reduces the systemic inflammatory response.These effects require further evaluation for using in a clinical setting. | Mateus Antunes Nogueira Ana Maria Mendona Coelho Sandra Nassa Sampietre Rosely Antunes Patzina Fabiano Pinheiro da Silva Luiz Augusto Carneiro D'Albuquerque Marcel Cerqueira Cesar Machado | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 7 | 牙周炎和院内获得性肺炎之间的关联:观察性研究的系统评价和荟萃分析显示文摘目的:评估重症监护病房(ICU)患者的牙周炎与院内获得性肺炎之间的关联。材料和方法:本研究依据系统评价和荟萃分析的首选报告项目(PRISMA)的指南进行,并已在PROSPERO(国际前瞻性系统评价注册,英国约克大学)注册,注册号为CRD42018105124。本研究在五个数据库中进行了搜索,没有语言或出版日期的限制。在检索的560项研究中,对10篇进行了全文分析,其中五项病例对照研究符合条件,纳入荟萃分析。荟萃分析结果通过敏感性分析和异质性检验进行评价。通过比值比(OR)和95%置信区间计算简要效果量度。结果:在苔萃分析中.牙周炎与院内获得性肺炎之间存在显著相关性(OR 2.55,95%CI:1.68-3.86)。在此荟萃分析中,12=0%。结论:证据表明牙周炎与院内获得性肺炎之间呈正相关。与没有牙周炎的患者相比,入住ICU的牙周炎患者更容易出现院内获得性肺炎。 | Laura Silva Jeronimo Lucas Guimaraes Abreu Fabiano Araujo Cunha Rafael Paschoal Esteves Lima 程梦琳(译) 张珊珊(审) 郑树国(审) | 2020 | 中国口腔医学继续教育杂志2020，23，5： | 2 |
| 8 | Therapeutic and biological activities of Calotropis procera(Ait.) R.Br.显示文摘Medicinal plants have been used to treat various ailments of the poor population around the world;hence the interest among researchers to know the active ingredients of certain plants has being increased.The Calotropis procera(C.procera) is a plant original from Africa,commonly found in northeastern Brazil.It is well known for their pharmacological properties,since it produces large amounts of latex.The important role that medicinal plants play in folk medicine has led us to develop this article in order to review the major pharmacological activities of C. procera. | Marcia Calheiros Chaves Silva Antonio Batista da Silva Fabiano Moura Teixeira Paulo Cesar Pereira de Sousa Regina Maria Macedo Rondon Jose Eduardo Ribeiro Honorio Junior Luiz Rafael Leite Sampaio Samanda Lima Oliveira Angela Nadyla Martins Holonda Silvania Maria Mendes de Vasconcelos | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，4： | 2 |
| 9 | MRI findings in the diag- nosis and monitoring of Rasmussen's encephalitis 显示文摘 | Andr6ia V Fabiano R Guilherme C | 2009 | Arq Neurop- siquiatr2009，67，3： | 1 |
| 10 | Assessment of corrosion resistance of Nd-Fe-B magnets by silanization for orthodontic applications显示文摘 | Fabiano F Celegato F Giordano A | 2014 | Physica B: Condensed Matter2014，435，： | 1 |
| 11 | Emergy required for the complete treatment of municipal wsstewater显示文摘 | Vassallo P Paoli C Fabiano M | | 0，，05： | 1 |
| 12 | A network flow based heuristic approach for optimising AGV movements 显示文摘 | CONFESSORE G FABIANO M LIOT'FA G | 2011 | Journal of Intelligent Manufacturing2011，24，2： | 1 |
| 13 | Distillation of radioactive liquid organic waste for subsequent wet oxidation显示文摘 | Fabiano B Pastorino R Ferrando M | 1998 | Journal of Hazardous Materials1998，57，： | 1 |
| 14 | Expression of hMSH2 and hMLH1 proteins of the human mismatch repair system in salivary gland tumors显示文摘 | Castrilli G Fabiano A La Torre G | 2002 | J Oral Pathol Med2002，31，4： | 1 |
| 15 | Bioavailability of organic matter in the sediments of the Porcupine Abyssal Plain, northeastern At- lantic显示文摘 | DANOVARO R DELL ANNO A FABIANO M | 2001 | Mar Ecol Progr Ser2001，220，： | 1 |
| 16 | Photocatalytic activity of nanoneedles, nanospheres, and polyhedral shaped ZnO powders in organic dye degradation processes显示文摘 | Felipe Antonio Lucca Sánchez Antonio Shigueaki Takimi Fabiano Severo Rodembusch Carlos Pérez Bergmann | 2013 | Journal of Alloys and Compounds2013，，： | 1 |
| 17 | High resolution multicontrast-weighted MR imaging from human carotid endarterectomy specimens to assess carotid plaque components显示文摘 | Fabiano S Mancino S Stefanini M | 2008 | Eur Radiol2008，18，： | 1 |
| 18 | A liquid - liquid extraction procedure followed by a low temperature purification step for the analysis of macrocyclic lac- tones in milk by liquid chromatography - tandem mass spectrom- etry and fluorescence detection 显示文摘 | Gabriel Riibensam Fabiano Barreto Rodrigo Barcellos Hoff | 2011 | Analytica Chimica Acta2011，705，12： | 1 |
| 19 | A framework for risk assessment and decision-making strategies in dangerous good transportation显示文摘 | Fabiano B Curr6 F Palazzi E | 2002 | Journal of Hazardous Materials2002，93，1： | 1 |
| 20 | Coal dust emissions: From environmental control to risk minimization by underground transport. An applicative case-study显示文摘 | B. Fabiano F. Currò A.P. Reverberi E. Palazzi | 2013 | Process Safety and Environmental Protection2013，，： | 1 |
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