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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | Information Hiding-A Survey显示文摘 | Fabien A P Petitcolas Ross J Anderson Markus G Kuhn | 1999 | Prpceedings of the IEEE1999，87，7： | 1 |
| 3 | Information hiding: a survey显示文摘 | FABIEN A P P ROSS J A MARKUS G K | 1999 | Proceedings of the IEEE Special Issue on Protection of Multimedia Content1999，87，7： | 1 |
| 4 | Information Hiding-A Survey显示文摘 | Fabien A P Petitcolas Ross J Anderson | 1999 | Proceedings of the IEEE1999，87，7： | 1 |
| 5 | Information Hiding-A Survey显示文摘 | Ross J Anderson Markus G Kuhn | 1999 | Proceedings of the IEEE Special Issue on Protection of Multimedia Content1999，87，7： | 1 |
| 6 | On the Limits of Steganography显示文摘 | Fabien A P Petitcolas | 1998 | IEEE Journal of Selected Areas in Communications1998，16，4： | 1 |
| 7 | Watermarking schemes evaluation 显示文摘 | Petitcolas Fabien A P | 2000 | IEEE Signal Processing2000，17，5： | 1 |
| 8 | Synthesis of kdp nanocrystals in micellar solutions of block copolymers of poly ( styrene ) and poly ( oxyethylene ) 显示文摘 | Jung K O Fabien P Matyjaszewski K | 2006 | Polymer Preprints2006，47，： | 1 |
| 9 | Information hiding - a survey 显示文摘 | Petitcolas Fabien A P Anderson Ross J Kuhn Markus G | 1999 | Proceedings of theIEEE1999，87，7： | 1 |
| 10 | Information hiding-A survey显示文摘 | Fabien A P Petitcolas Ross J Anderson Markus G Kohn | 1999 | Proceedings of the IEEE1999，87，7： | 1 |
| 11 | Information hiding-a survey显示文摘 | Fabien Petitcolas A P Ross J Anderson Markus G Kuhn | 1999 | Proceedings of the IEEE1999，87，7： | 1 |
| 12 | Watermarking schemes evaluation显示文摘 | FABIEN A P P | 2000 | IEEE Signal Proceedings2000，17，5： | 1 |
| 13 | Information Hiding-A Survey 显示文摘 | Fabien A P Ross J Petitcalas Anderson Markus G Kuhn | 1987 | Proceedings of the IEEE special issue on protection of multimedia content1987，，7： | 1 |
| 14 | On the limits of steganography 显示文摘 | ROSS J A FABIEN A P P | 1998 | IEEE Journal of Selected Areas in Communications1998，16，4： | 1 |
| 15 | Information Hiding A Survey 显示文摘 | Fabien A P Petit co las Ro ss J Anderson Mar kus G Kuhn | 1999 | Proceedings of the IEEE1999，87，10： | 1 |
| 16 | Information hiding-a survey 显示文摘 | Fabien A P Anderson R J Markus G K | 1999 | Proceedings of the IEEE1999，7，7： | 1 |
| 17 | Growth and irreversible pollution:are emission permits a means of avoiding environmental and poverty traps显示文摘 | Fabien P Alain J M Mabel T | 2013 | Macroeconomic Dynamics2013，17，2： | 1 |
| 18 | High-level secrctory production of recombinant porcine follicle-stimulating hormone by Pichia pastoris显示文摘 | Boze H Laborde C Chemardin P Fabien R Venturin C Combarnous Y Moulin G | | 0，，： | 1 |
| 19 | Piezoelectric vibration energy harvesting by optimized synchronous electric charge extraction显示文摘 | WU Y P ADRIEN B FABIEN F | 2013 | J Intell Mater Syst Struct2013，24，12： | 1 |
| 20 | Information hiding -- a survey显示文摘 | Fabien A P Petitcolas R J Anderson | 1999 | Proceedings of the IEEE1999，87，7： | 1 |
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