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| 1 | Right ventricular septal pacing: Safety and efficacy in a long term follow up显示文摘AIM: To evaluate the safety and efficacy of the permanent high interventricular septal pacing in a long term follow up, as alternative to right ventricular apical pacing. METHODS: We retrospectively evaluated:(1) 244 patients(74 ± 8 years; 169 men, 75 women) implanted with a single(132 pts) or dual chamber(112 pts) pacemaker(PM) with ventricular screw-in lead placed at the right ventricular high septal parahisian site(SEPTAL pacing);(2) 22 patients with permanent pacemaker and low percentage of pacing(< 20%)(NO pacing);(3) 33 patients with high percentage(> 80%) right ventricular apical pacing(RVA). All patients had a narrow spontaneous QRS(101 ± 14 ms). We evaluated New York Heart Association(NYHA) class, quality of life(Qo L), 6 min walking test(6MWT) and left ventricular function(end-diastolic volume, LV-EDV; end-systolic volume, LVESV; ejection fraction, LV-EF) with 2D-echocardiography. RESULTS: Pacing parameters were stable duringfollow up(21 mo/patient). In SEPTAL pacing group we observed an improvement in NYHA class, Qo L score and 6MWT. While LV-EDV didn't significantly increase(104 ± 40 m L vs 100 ± 37 m L; P = 0.35), LV-ESV slightly increased(55 ± 31 m L vs 49 ± 27 m L; P = 0.05) and LV-EF slightly decreased(49% ± 11% vs 53% ± 11%; P = 0.001) but never falling < 45%. In the RVA pacing control group we observed a worsening of NYHA class and an important reduction of LV-EF(from 56% ± 6% to 43% ± 9%, P < 0.0001).CONCLUSION: Right ventricular permanent high septal pacing is safe and effective in a long term follow up evaluation; it could be a good alternative to the conventional RVA pacing in order to avoid its deleterious effects. | Eraldo Occhetta Gianluca Quirino Lara Baduena Rosaria Nappo Chiara Cavallino Emanuela Facchini Paolo Pistelli Andrea Magnani Miriam Bortnik Gabriella Francalacci Gabriele Dell’Era Laura Plebani Paolo Marino | 2015 | World Journal of Cardiology2015，7，8： | 5 |
| 2 | Ovarian cancer standard of care: are there real alternatives?显示文摘Ovarian cancer remains a major issue for gynecological oncologists, and most patients are diagnosed when the disease is already advanced with a poor chance of survival. Debulking surgery followed by platinum-taxane chemotherapy is the current standard of care, but based on several different strategies currently under evaluation, some encouraging data have been published in the last 4 to 5 years. This review provides a state-of-the-art overview of the available alternatives to conventional treatment and the most promising new combinations. For example, neoadjuvant chemotherapy does not seem to be inferior to primary debulking. Despite its outcome improvements, intraperitoneal chemotherapy struggles for acceptance due to the heavy toxicity. Dose-dense chemotherapy, after showing an impressive efficacy in Asian populations, has not produced equal results in a European cohort, and the results of alternative platinum doublets are not superior to those of carboplatin and paclitaxel. In this setting, adherence to a maintenance therapy after first-line treatment and multiple(primarily antiangiogenic) agents appears to be effective. Although many questions, including the duration of maintenance treatment and the use of bevacizumab beyond progression, remain unanswered, new biologic agents, such as poly(ADP-ribose) polymerase(PARP) inhibitors, nintedanib, and mitogen-activated protein/extracellular signal-regulated kinase(MEK) inhibitors, have emerged as potential therapeutic options in the very near future. Based on the multiplicity of available strategies, the histological and molecular features of the tumor, in addition to patient's clinical condition and disease state, continue to gain importance in guiding treatment choices. | Chiara Della Pepa Giuseppe Tonini Carmela Pisano Marilena Di Napoli Sabrina Chiara Cecere Rosa Tambaro Gaetano Facchini Sando Pignata | 2015 | Chinese Journal of Cancer2015，34，1： | 5 |
| 3 | The gains from duty free zones显示文摘 | Giovanni Facchini Gerald Willmann | 1999 | Journal of International Economics1999，，2： | 2 |
| 4 | Effect of iron depletion in carbohydrate-intolerant patients with clinical evidence of nonalcoholic fatty liver disease显示文摘 | Francesco S. Facchini Nancy W. Hua Riccardo A. Stoohs | 2002 | Gastroenterology2002，，4： | 2 |
| 5 | Possible prognostic role of IL-17R in osteosarcoma 显示文摘 | Honorati MC Cattini L Facchini A | 2007 | Cancer Res Clin Oncol2007，133，12： | 1 |
| 6 | Plant aromatic L-amino acid decarboxylases:evolution,biochemistry,regulation,and metabolic engineering applications显示文摘 | FACCHINI P J HUBER ALLANACH K L TARI L W | 2000 | Phytochemistry2000，54，2： | 1 |
| 7 | Wind response of large roofs of stations and arena显示文摘 | Biagini P Borri C Facchini L | 2007 | Journal of Wind Engineering and Industrial Aerodynamics2007，95，911： | 1 |
| 8 | Effect of central and peripheral body fat distribution on sympathetic and baroreflex function in obese normotensives显示文摘 | Grassi G Dell'Oro R Facchini A | 2004 | J Hypertens2004，22，12： | 1 |
| 9 | Effect of central and peripheral body fat distribution on sympathetic and baroreflex function in obese normotensives显示文摘 | Grassi G Dell'Oro R Facchini A | 2004 | J Hypertens2004，22，12： | 1 |
| 10 | Ductility of a Ti6A14V alloy produced by selective laser melting of prealloyed powders显示文摘 | Facchini L Magalini E Robotti P | 2010 | Rapid Prototyping Journal2010，16，6： | 1 |
| 11 | Study of humic-like substances in fog and interstitial aerosol by size-exclusion chromatography and capillary electrophoresis显示文摘 | Z Krivácsy Gy Kiss B Varga I Galambos Zs Sárvári A Gelencsér á Molnár S Fuzzi M.C Facchini S Zappoli A Andracchio T Alsberg H.C Hansson L Persson | 2000 | Atmospheric Environment2000，，25： | 1 |
| 12 | The molecular role of Myc in growth and transformation:recent discoveries lead to new insights显示文摘 | Facchini LM Penn LZ | 1998 | FASEB J1998，12，9： | 1 |
| 13 | The molecular role of Myc in growth and transformation: recent discoveries lead to new insights 显示文摘 | Facchini LM Penn LZ | 1998 | FASEB J1998，12，9： | 1 |
| 14 | Experimental Investigation on Leakage Loss and Heat Transfer in a Straight through Labyrinth Seal 显示文摘 | Micio M Facchini B Innocenti L | 2011 | Heat Transfer2011，5，： | 1 |
| 15 | Biochemical approach to di- agnosis and differentiation of primary hyperoxalurias: an update 显示文摘 | Petrarulo M Vitale C Facchini P | 1998 | J Nephrol1998，1，1： | 1 |
| 16 | Gene Family for an Elicitor-Induced Sesquiterpene Cyclase in Tobacco显示文摘 | Chappell J | 1992 | PNAS1992，89，11： | 1 |
| 17 | Treatment of recurrent epi-thelial ovarian cancer显示文摘 | Pisano C Bruni GS Facchini G | 2009 | Ther Clin Risk Manag2009，5，4： | 1 |
| 18 | Blade cooling improvement for heavy duty gas turbine: the air coolant temperature reduction and the introduction of steam and mixed steam/air cooling 显示文摘 | FACCHINI B GIOVANNI F INNOCENTI L | 2000 | Int J of Therm Sci2000，39，1： | 1 |
| 19 | Proautophagic drugs: a novel means to combat apoptosis-resistant cancers, with a special emphasis on glioblastornas 显示文摘 | LEFRANC F FACCHINI V KISS R | 2007 | Oncologist2007，12，12： | 1 |
| 20 | IL-17,IL-1beta and TNF-alpha stimulate VEGF production by dedifferentiated chondrocytes显示文摘 | Honorati MC Cattini L Facchini A | 2004 | Osteoarthritis Cartilage2004，12，9： | 1 |
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