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| 1 | Liver transplantation for hepatocellular carcinoma:an update显示文摘BACKGROUND: Hepatocellular carcinoma (HCC) is a heterogeneous malignancy with multiple etiologies, high incidence, and high mortality. The standard surgical management for patients with HCC consists of locoregional ablation, surgical resection, or liver transplantation, depending on the background state of the liver. Eighty percent of patients initially presenting with HCC are unresectable, either due to the extent of tumor or the level of underlying hepatic dysfunction. While in patients with no evidence of cirrhosis and good hepatic function resection has been the surgical treatment of choice, it is contraindicated in patients with moderate to severe cirrhosis. Liver transplantation is the optimal surgical treatment. DATA SOURCES: PubMed search of recent articles (from January 2000 to March 2011) was performed looking for relevant articles about hepatocellular carcinoma and its treatment. Additional articles were identified by evaluating references from selected articles. RESULTS: Here we review criteria for transplantation, the types, indications, and role of locoregional therapy in treating the cancer and in downstaging for possible later transplantation. We also summarize the contribution of immunosuppression and adjuvant chemotherapy in the management and prevention of HCC recurrence. Finally we discuss recent advances in imaging, tumor biology, and genomics as we delineate the remaining challenges for the diagnosis and treatment of this disease. CONCLUSIONS: Much can be improved in the diagnosis and treatment of HCC. A great challenge will be to improve patient selection to criteria based on tumor biology. Another will be to incorporate systemic agents post-operatively in patients at high risk for recurrence, paying close attention to efficacy and safety. The future direction of the effort in treating HCC will be to stimulate prospective trials, develop molecular imaging of lymphovascular invasion, to improve recipient selection, and to investigate biomarkers of tumor biology. | Ali Zarrinpar Fady Kaldas Ronald W Busuttil | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 8 |
| 2 | Split-dose menthol-enhanced PEG vs PEG-ascorbic acid for colonoscopy preparation显示文摘AIM:To compare the efficacy and palatability of 4L polyethylene glycol electrolyte(PEG)plus sugar-free menthol candy(PEG+M)vs reduced-volume 2 L ascorbic acid-supplemented PEG(Asc PEG).METHODS:In a randomized controlled trial setting,ambulatory patients scheduled for elective colonoscopy were prospectively enrolled.Patients were randomized to receive either PEG+M or Asc PEG,both splitdosed with minimal dietary restriction.Palatability was assessed on a linear scale of 1 to 5(1=disgusting;5=tasty).Quality of preparation was scored by assignment-blinded endoscopists using the modified Aronchick and Ottawa scales.The main outcomes were the palatability and efficacy of the preparation.Secondary outcomes included patient willingness to retake the same preparation again in the future and completion of the prescribed preparation.RESULTS:Overall,200 patients were enrolled(100patients per arm).PEG+M was more palatable than Asc PEG(76%vs 62%,P=0.03).Completing the preparation was not different between study groups(91%PEG+M vs 86%Asc PEG,P=0.38)but more patients were willing to retake PEG+M(54%vs 40%respectively,P=0.047).There was no significant difference between PEG+M vs Asc PEG in adequate cleansing on both the modified Aronchick(82%vs77%,P=0.31)and the Ottawa scale(85%vs 74%,P=0.054).However,PEG+M was superior in the left colon on the Ottawa subsegmental score(score0-2:94%for PEG+M vs 81%for Asc PEG,P=0.005)and received significantly more excellent ratings than Asc PEG on the modified Aronchick scale(61%vs 43%,P=0.009).Both preparations performed less well in afternoon vs morning examinations(inadequate:29%vs 15.2%,P=0.02).CONCLUSION:4 L PEG plus menthol has better palatability and acceptability than 2 L ascorbic acidPEG and is associated with a higher rate of excellentpreparations;Clinicaltrial.gov identifier:NCT01788709. | Ala I Sharara Ali H Harb Fayez S Sarkis Jean M Chalhoub Rami Badreddine Fadi H Mourad Mahmoud Othman Omar Masri | 2015 | World Journal of Gastroenterology2015，21，6： | 2 |
| 3 | Liver Transplantation for Nonalcoholic Steatohepatitis: The New Epidemic显示文摘 | Vatche G. Agopian Fady M. Kaldas Johnny C. Hong Meredith Whittaker Curtis Holt Abbas Rana Ali Zarrinpar Henrik Petrowsky Douglas Farmer Hasan Yersiz Victor Xia Jonathan R. Hiatt Ronald W. Busuttil | 2012 | Annals of Surgery2012，，4： | 2 |
| 4 | Liver Transplantation for Nonalcoholic Steatohepatitis: The New Epidemic显示文摘 | Vatche G. Agopian Fady M. Kaldas Johnny C. Hong Meredith Whittaker Curtis Holt Abbas Rana Ali Zarrinpar Henrik Petrowsky Douglas Farmer Hasan Yersiz Victor Xia Jonathan R. Hiatt Ronald W. Busuttil | 2012 | Annals of Surgery2012，，4： | 2 |
| 5 | Evaluating transfers of aroma compounds during the concentration of sucrose solutions by osmotic distillation in a batchtype pilot plant显示文摘 | Fadi Ali Manuel Dornier Albert Duquenoy | 2003 | Journal of Food Engineering2003，60，1： | 1 |
| 6 | Contemporary management of subarachnoid hemorrhage and vasospasm: the UIC experience显示文摘 | Luke Corsten Ali Raja Kern Guppy Ben Roitberg Mukesh Misra M.Serdar Alp Fady Charbel Gerard Debrun James Ausman | 2001 | Surgical Neurology2001，，3： | 1 |
| 7 | Liver Transplantation for Nonalcoholic Steatohepatitis: The New Epidemic显示文摘 | Vatche G. Agopian Fady M. Kaldas Johnny C. Hong Meredith Whittaker Curtis Holt Abbas Rana Ali Zarrinpar Henrik Petrowsky Douglas Farmer Hasan Yersiz Victor Xia Jonathan R. Hiatt Ronald W. Busuttil | 2012 | Annals of Surgery2012，，4： | 1 |
| 8 | A Novel Prognostic Nomogram Accurately Predicts Hepatocellular Carcinoma Recurrence after Liver Transplantation: Analysis of 865 Consecutive Liver Transplant Recipients显示文摘 | Vatche G. Agopian Michael Harlander-Locke Ali Zarrinpar Fady M. Kaldas Douglas G. Farmer Hasan Yersiz Richard S. Finn Myron Tong Jonathan R. Hiatt Ronald W. Busuttil | 2014 | Journal of the American College of Surgeons2014，，： | 1 |
| 9 | Contemporary management of subarachnoid hemorrhage and vasospasm: the UIC experience显示文摘 | Luke Corsten Ali Raja Kern Guppy Ben Roitberg Mukesh Misra M.Serdar Alp Fady Charbel Gerard Debrun James Ausman | 2001 | Surgical Neurology2001，，3： | 1 |
| 10 | Preoperative anaemia and postoperative outcomes in non-cardiac surgery: a retrospective cohort study显示文摘 | Khaled M Musallam Hani M Tamim Toby Richards Donat R Spahn Frits R Rosendaal Aida Habbal Mohammad Khreiss Fadi S Dahdaleh Kaivan Khavandi Pierre M Sfeir Assaad Soweid Jamal J Hoballah Ali T Taher Faek R Jamali | 2011 | The Lancet2011，，9800： | 1 |
| 11 | Expression, prognostic and predictive impact of VEGF and bFGF in non-small cell lung cancer显示文摘 | Fadi S. Farhat Arafat Tfayli Najla Fakhruddin Rami Mahfouz Zaher K. Otrock Raafat S. Alameddine Ahmad H. Awada Ali Shamseddine | 2012 | Critical Reviews in Oncology / Hematology2012，，2： | 1 |
| 12 | Expression, prognostic and predictive impact of VEGF and bFGF in non-small cell lung cancer显示文摘 | Fadi S. Farhat Arafat Tfayli Najla Fakhruddin Rami Mahfouz Zaher K. Otrock Raafat S. Alameddine Ahmad H. Awada Ali Shamseddine | 2012 | Critical Reviews in Oncology / Hematology2012，，2： | 1 |
| 13 | Characteristics and Outcomes of Patients With Advanced Chronic Systolic Heart Failure Receiving Care at the Veterans Affairs Versus Other Hospitals: Insights From the Beta-blocker Evaluation of Survival Trial (BEST)显示文摘 | Linda G. Jones Mo-Kyung Sin Fadi G. Hage Raya E. Kheirbek Charity J. Morgan Michael R. Zile Wen-Chih Wu Prakash Deedwania Gregg C. Fonarow Wilbert S. Aronow Sumanth D. Prabhu Ross D. Fletcher Ali Ahmed Richard M. Allman | 2015 | Circulation: Heart Failure2015，，1： | 1 |
| 14 | Effect of Acute Cocaine Use on Vasospasm and Outcome in Aneurysmal Subarachnoid Hemorrhage显示文摘 | Ali Alaraj Adam Wallace Navneet Mander Victor Aletich Fady T. Charbel Sepideh Amin-Hanjani | 2010 | World Neurosurgery2010，，4： | 1 |
| 15 | Repair of an aberrant subclavian arterioesophageal fistula following esophageal stent placement显示文摘A fistula formation between the esophagus and an aberrant right subclavian artery is a rare but fatal com-plication that has been mostly described in the setting of prolonged nasogastric intubation and foreign body erosion. We report a case of a young morbidly obese patient who underwent sleeve gastrectomy that was complicated by a postoperative leak at the level of the gastroesophageal junction. A covered esophageal stent was placed endoscopically to treat the leak. The pa-tient developed massive upper gastrointestinal bleeding secondary to the erosion of the stent into an aberrant retroesophageal right subclavian artery twelve days after stent placement. She was ultimately treated by endovascular stenting of the aberrant right subclavian artery followed by thoracotomy and esophageal repair over a T-tube. This case report highlights the multidis-ciplinary approach needed to diagnose and managesuch a devastating complication. It also emphasizes the need for imaging studies prior to stent deployment to delineate the vascular anatomy and rule out the possi-bility of such an anomaly in view of the growing popu-larity of esophageal stents, especially in the setting of a leak. | Maen Aboul Hosn Fady Haddad Fadi El-Merhi Bassem Safadi Ali Hallal | 2014 | World Journal of Gastrointestinal Surgery2014，6，6： | 0 |
| 16 | Typical atrial flutter from blunt cardiac injury:an atypical cause显示文摘Atrial flutter(AFL)is a detrimental cardiac arrhythmia caused by multiple pathologic conditions.Certain unsuspecting cases,however,may be an inciting factor.Among them is blunt cardiac injury(BCI),characterized by nonpenetrating mediastinal trauma,leading to arrhythmias due to myocardial tissue injury.AFL is a rare sequela of BCI that has seldom been reported.We present a case of a healthy 50-year-old lady who was incidentally diagnosed with AFL in the setting of BCI. | Naji Maaliki Fadi Kandah Aleem Azal Ali James Farah Temitope Akinjogbin Francesco Franchi | 2021 | Journal of Geriatric Cardiology2021，18，2： | 0 |
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