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| 1 | 食道的有鳞的房间癌 - 先锋损害和早诊断显示文摘 Squamous cell carcinoma of the esophagus (SCCE) carries a poor prognosis due to late diagnosis.Early detection is highly desirable,since surgical and endoscopic resection offers the only possible cure for esophageal cancer.Population screening should be undertaken in high risk areas,and in low or moderate risk areas for people with risk factors (alcoholics,smokers,mate drinkers,history of head and neck cancer,achalasia and lye stricture of the esophagus).Esophageal balloon cytology is an easy and inexpensive sampling technique,but the current methods are insufficient for primary screening due to sampling errors.Conventional endoscopy with biopsy remains the standard procedure for the identification of pre-malignant and early malignant changes in esophageal mucosa and endoscopic detection.It may be enhanced by several techniques such as dye and optic chromoendoscopy,magnifying endoscopy,and optical-based spectroscopic and imaging modalities.Since more than 80% of SCCE deaths occur in developing countries,where expensive techniques such as narrow band imaging (NBI) and autofluorescence imaging are unavailable,the most cost-effective tool for targeting biopsies may be Lugol dye chromoendoscopy,since it is easy,accurate,inexpensive and available worldwide.In ideal conditions,or in developed countries,is it reasonable to think that optimal detection will require a combination of techniques,such as the combination of Lugol’s chromoendoscopy and NBI to identify esophageal areas that require further characterization by a high resolution technique.The efficacy and cost-effectiveness will determine whether these modalities will become part of standard endoscopy practice. | Antonio Barros Lopes Renato Borges Fagundes | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，1： | 20 |
| 2 | pRB expression in esophageal mucosa of individuals at high risk for squamous cell carcinoma of the esophagus显示文摘AIM: To investigate the pRb expression in a large group of patients with history of chronic exposure to the main risk factors for development of squamous cell carcinoma of the esophagus. METHODS: One hundred and seventy asymptomatic individuals at high risk for esophageal squamous cell carcinoma (consumption of more than 80 g of ethanol and 10 cigarettes/d for at least 10 years) underwent upper gastrointestinal endoscopy with biopsies of the esophageal mucosa. As a control group, specimens of esophageal mucosa obtained from 20 healthy subjects were also studied. Immunohistochemical assessment of the tissues was performed using a monoclonal antibody anti-pRB protein. RESULTS: Absence of the pRB staining, indicating loss of RB function, was observed in 33 (19.4%) of the individuals at risk for esophageal cancer, but in none of the healthy controls (P < 0.02). Loss of pRb expression increased in a stepwise fashion according to the severity of the histological findings (P < 0.005): normal mucosa (11/97 or 11.3%), chronic esophagitis (17/60 or 28.3%), low-grade dysplasia (3/10 or 30%), high-grade dysplasia 1/2 or 50%) and squamous cell carcinoma (1/1 or 100%). CONCLUSION: Our findings suggest that abnormal expression of the pRB protein may be implicated in the process of esophageal carcinogenesis. Additional studies are warranted to define the role of the pRBprotein as a biomarker for development of esophageal squamous cell carcinoma in individuals at high risk for this malignancy. | Simone S Contu Paulo C Contu Daniel C Damin Renato B Fagundes Fabiano Bevilacqua Aline S Rosa Joo C Prolla Luis F Moreira | 2007 | World Journal of Gastroenterology2007，13，11： | 5 |
| 3 | Contractile effect of tachykinins on rabbit sma intestine显示文摘 | Marta Sofia VALERO Diego Santos FAGUNDES Laura GRASA Maria Pilar ARRUEBO Miguel Angel PLAZA Maria Divina MURILLO | 2011 | Acta Pharmacologica Sinica2011，32，4： | 5 |
| 4 | No evidence of HPV DNA in esophageal squamous cell carcinoma in a population of Southern Brazil显示文摘AIM:To investigate the association between human papillomavirus(HPV)and esophageal squamous cell carcinoma(ESCC)in southern Brazil.METHODS:We studied 189 esophageal samples from125 patients from three different groups:(1)102 biopsies from 51 patients with ESCC,with one sample from the tumor and another from normal esophageal mucosa distant from the tumor;(2)50 esophageal biopsies from 37 patients with a previous diagnosis of head and neck squamous cell carcinoma(HNSCC);and(3)37 biopsies from esophageal mucosa with normal appearance from 37 dyspeptic patients,not exposed to smoking or alcohol consumption.Nested-polymerase chain reaction(PCR)with the MY09/11 and GP5/6 L1primers was used to detect HPV L1 in samples fixed in formalin and stored in paraffin blocks.All PCR reactions were performed with a positive control(cervicovaginal samples),with a negative control(Human Genomic DNA)and with a blank reaction containing all reagents except DNA.We took extreme care to prevent DNA contamination in sample collection,processing,and testing.RESULTS:The histological biopsies confirmed the diagnosis of ESCC in 52 samples(51 from ESCC group and 1 from the HNSCC group)and classified as well differentiated(12/52,23.1%),moderately differentiated(27/52,51.9%)or poorly differentiated(7/52,13.5%).One hundred twenty-eight esophageal biopsies were considered normal(51 from the ESCC group,42 from the HNSCC group and 35 from dyspeptic patients).Nine had esophagitis(7 from the HNSCC and 2 from dyspeptic patients).Of a total of 189 samples,only 6 samples had insufficient material for PCR analysis:1 from mucosa distant from the tumor in a patient with ESCC,3from patients with HNSCC and 2 from patients without cancer.In 183 samples(96.8%)GAPDH,G3PDH and/orβ-globin were amplified,thus indicating the adequacy of the DNA in those samples.HPV DNA was negative in all the 183 samples tested:52 with ESCC,9 with esophagitis and 122 with normal esophageal mucosa.CONCLUSION:There was no evidence of HPV infection in different ESCC from southern Brazil. | Luís Carlos Moreira Antunes Joo Carlos Prolla Antonio de Barros Lopes Marta Pires da Rocha Renato Borges Fagundes | 2013 | World Journal of Gastroenterology2013，19，39： | 4 |
| 5 | Autoimmune hepatitis in childhood: The role of genetic and immune factors显示文摘Autoimmune hepatitis (AIH) is a rare chronic inflammatory disease of the liver, which affects a group of patients who lost their immunological tolerance to antigens of the liver. It is clinically characterized by hypergammaglobulinemia, elevated liver enzymes, presence of autoantibodies and histological changes. Although being rare in children, it represents a serious cause of chronic hepatic disease that can lead to cirrhosis and hepatic failure. Clinical findings, exclusion of more common liver disorders and the detection of antibodies antinuclear antibodies, smooth muscle antibodies and anti-LKM1 are usually enough for diagnosis on clinical practice. The pathogenic mechanisms that lead to AIH remain obscure, but some research findings suggest the participation of immunologic and genetic factors. It is not yet knew the triggering factor or factors that stimulate inflammatory response. Several mechanisms proposed partially explain the immunologic findings of AIH. The knowledge of immune factors evolved might result in better markers of prognosis and response to treatment. In this review, we aim to evaluate the findings of research about genetic and immune markers and their perspectives of application in clinical practice especially in pediatric population. | Priscila Menezes Ferri Liu Débora Marques de Miranda Eleonora Druve Tavares Fagundes Alexandre Rodrigues Ferreira Ana Cristina Simoes e Silva | 2013 | World Journal of Gastroenterology2013，19，28： | 3 |
| 6 | Assessment of disease activity in inflammatory bowel diseases:Non-invasive biomarkers and endoscopic scores显示文摘Inflammatory bowel diseases(IBD)comprise two major forms:Crohn’s disease and ulcerative colitis.The diagnosis of IBD is based on clinical symptoms combined with results found in endoscopic and radiological examinations.In addition,the discovery of biomarkers has significantly improved the diagnosis and management of IBD.Several potential genetic,serological,fecal,microbial,histological and immunological biomarkers have been proposed for IBD,and they have been evaluated for clinical routine and clinical trials.Ileocolonoscopy,especially with biopsy collection,has been considered the standard method to diagnose IBD and to assess clinical activity of the disease,but it is limited to the colon and terminal ileum and is considered invasive.For this reason,non-invasive biomarkers are necessary for this type of chronic inflammatory disease,which affects mostly young individuals,as they are expected to have a long follow-up. | Bruno Lima Rodrigues Marcia Carolina Mazzaro Cristiane Kibune Nagasako Maria de Lourdes SetsukoAyrizono Joao Jose Fagundes Raquel Franco Leal | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，12： | 2 |
| 7 | Urinary neutrophil gelatinase-associated lipocalin as biomarker in the differential diagnosis of impairment of kidney function in cirrhosis显示文摘 | Claudia Fagundes Marie-No?lle Pépin Mónica Guevara Rogelio Barreto Gregori Casals Elsa Solà Gustavo Pereira Ezequiel Rodríguez Elisabet Garcia Verónica Prado Esteban Poch Wladimiro Jiménez Javier Fernández Vicente Arroyo Pere Ginès | 2012 | Journal of Hepatology2012，，2： | 2 |
| 8 | Esophageal involvement and interstitial lung disease in mixed connective tissue disease 显示文摘 | Fagundes MN Caleiro MT Navarro-Rodriguez T | 2009 | Respir Med2009，103，6： | 1 |
| 9 | Brain-blood barrier breakdown and pro-inflammatory mediators in neonate rats submitted meningitis by Streptococcus pneumonia 显示文摘 | Barichello T Fagundes GD Generoso JS | 2012 | Brain Res2012，1471，： | 1 |
| 10 | Direct contact with particulate matter increases oxidative stress in differ- ent brain structures 显示文摘 | Fagundes LS Fleck Ada S Zanchi AC | 2015 | Inhalation Toxicology2015，27，10： | 1 |
| 11 | Continuous positive airway pressure acutely increases exercise duration in children with severe therapy-resistant asthma:a randomized crossover trial显示文摘Background Lower exercise tolerance is an important component of asthma and the possible effects of non-invasive ven-tilation on exercise capacity in individuals with severe therapy-resistant asthma(STRA)are unknown.This study aimed to evaluate the immediate effect of continuous positive airway pressure(CPAP)on exercise tolerance in children with STRA.Methods We performed a controlled,randomized,crossover clinical trial including subjects aged 6 to 18 years old diagnosed with STRA.Clinical,anthropometric and lung function data were collected.The participants in the intervention group(IG)used CPAP(PEEP 10cmH2O and FiO20.21)for a period of 40 min.Subjects in the control group(CG)used CPAP with mini-mum PEEP at 1 cmH20 also for 40 min.Afterwards,subjects from both groups underwent cardiopulmonary exercise testing(CPET).After a 15-day washout period,on a subsequent visit,subjects participated in the opposite group to the initial one.Results Thirteen subjects with a mean age of 12.30±1.7 years were included.The variables of peak expiratory flow(PEF)and forced expiratory volume in the first second(FEV1)before using CPAP and after performing CPET did not show sig-nificant differences.Regarding CPET results,there was no significant difference(P=0.59)between groups at peak exercise for oxygen consumption—VO2(CG:33.4±6.3 and IG:34.5±5.9,mL kg^(-1)min^(-1)).However,the IG(12.4±2.1)presented a total test time(min)significantly(P=0.01)longer than the CG(11.5±1.3).Conclusion The results suggest that the use of CPAP before physical exercise increases exercise duration in children and adolescents with STRA. | Claudia Silva Schindel Daniele Schiwe Joao Paulo Heinzmann-Filho Natalia Evangelista Campos Paulo Marcio Pitrez Marcio Vinicius Fagundes Donadio | 2021 | World Journal of Pediatrics2021，17，2： | 1 |
| 12 | Identification of polymorphisms in the 5'- untranslated region of the TAFI gene: relationship with plasma TAFI levels and risk of venous thrombosis显示文摘 | Fagundes MG Meijers JC | 2001 | Haematologica2001，86，5： | 1 |
| 13 | The effect of root canalpreparation on microleakage within endodontically treated teeth:an in vitro study 显示文摘 | Von Fraunhofer JA Fagundes DK McDonald NJ | 2000 | Int Endod J2000，33，4： | 1 |
| 14 | Short atrioventricular Mahaim fibers:observations on their clinical,electrocardiographic,and electrophysiologic profile显示文摘 | Sternick EB Fagundes ML Cruz FE | 2005 | J Cardiovasc Electrophysiol2005，16，： | 1 |
| 15 | Signal-aver aged P wave in patients with Wolff Parkinson-White syn drome after successful radiofrequency catheter ablation 显示文摘 | Maia IG Cruz Filho FE Fagundes ML | 1995 | J Am Coil Cardiol1995，26，5： | 1 |
| 16 | The effect of root canal preparation on microleakage within endodonti- cally treated teeth: an in vitro study显示文摘 | Von Fraunhofer JA Fagundes DK Mcdonald N J | 2000 | Int Endod J2000，33，4： | 1 |
| 17 | Ultrasonographic fea-tures of papillary thyroid carcinoma显示文摘 | do Rosdrio PW Fagundes TA Maia FF | 2004 | J Ultrasound Med2004，23，： | 1 |
| 18 | The use of resorcine adhesive in repairing osteochondral\'s defect in knees of rabbits显示文摘 | Sakihama AK Fagundes DJ Inouye CM | 2006 | Acta Cir Bras2006，21，4： | 1 |
| 19 | Model of extensive and severe tracheal stenosis in dogs显示文摘 | Vaidergom J Fagundes D J Machado A L | 2008 | Acta Cir Bras2008，23，6： | 1 |
| 20 | The role of macrophage migration inhibitory factor in the cas- cade of events leading to reperfusion-induced inflam- matory injury and lethality 显示文摘 | Amaral FA Fagundes CT Guabiraba R | 2007 | Am J Pathol2007，171，6： | 1 |
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