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| 1 | Management of hypertension in primary aldosteronism显示文摘Hypertension causes significant morbidity and mortal-ity worldwide, owing to its deleterious effects on the cardiovascular and renal systems. Primary hyperaldo-steronism(PA) is the most common cause of revers-ible hypertension, affecting 5%-18% of adults with hypertension. PA is estimated to result from bilateral adrenal hyperplasia in two-thirds of patients, and from unilateral aldosterone-secreting adenoma in approxi-mately one-third. Suspected cases are initially screened by measurement of the plasma aldosterone-renin-ratio, and may be confirmed by additional noninvasive tests. Localization of aldostosterone hypersecretion is then determined by computed tomography imaging, and in selective cases with adrenal vein sampling. Solitary adenomas are managed by laparoscopic or robotic re-section, while bilateral hyperplasia is treated with min-eralocorticoid antagonists. Biochemical cure following adrenalectomy occurs in 99% of patients, and hemo-dynamic improvement is seen in over 90%, prompting a reduction in quantity of anti-hypertensive medica-tions in most patients. End-organ damage secondary to hypertension and excess aldosterone is significantly improved by both surgical and medical treatment, asmanifested by decreased left ventricular hypertrophy, arterial stiffness, and proteinuria, highlighting the im-portance of proper diagnosis and treatment of primary hyperaldosteronism. Although numerous independent predictors of resolution of hypertension after adrenalec-tomy for unilateral adenomas have been described, the Aldosteronoma Resolution Score is a validated multifac-torial model convenient for use in daily clinical practice. | Anna Aronova Thomas J Fahey Ⅲ Rasa Zarnegar | 2014 | World Journal of Cardiology2014，6，5： | 11 |
| 2 | Epigenetics of gastroenteropancreatic neuroendocrine tumors:A clinicopathologic perspective显示文摘Gastroenteropancreatic neuroendocrine tumors(GEP-NETs) are a heterogeneous group of rare tumors whose site-specific tumor incidence and clinical behavior vary widely. Genetic alterations associated with familial inherited syndromes have been well defined; however, the genetic profile of sporadic tumors is less clear as their tumorigenesis does not appear to be controlled by classic oncogenes such as P53, RB, or KRAS. Even within GEP-NETs, there are no common oncogenic drivers; for example, DAXX/ATRX mutations are strongly implicated in the tumorigenesis of pancreatic but not small bowel NETs. Accordingly, the dysregulation of epigenetic mechanisms has been hypothesized as a potential regulator of GEPNET tumorigenesis and has become a major focus of recent studies. Despite the heterogeneity of tumor cohorts evaluated in these studies, it is obvious that there are methylation patterns, chromatin remodeling alterations, and microR NA and long non-coding RNA(lncR NA) differential expression profiles that are distinctive of GEPNETs, some of which are correlated with significant differences in clinical outcomes. Several translational studies have provided convincing data identifying potential prognostic biomarkers, and some of these have demonstrated preliminary success as serum biomarkers that can be used clinically. Nevertheless, there are many opportunities to further define the mechanisms by which these epigenetic modifications influence tumorigenesis, and this will provide better insight into their prognostic and therapeutic utility. Furthermore, these findings form the foundation for future studies evaluating the clinical efficacy of epigenetic modifications as prognostic biomarkers, as well as potential therapeutic targets. | Brendan M Finnerty Katherine D Gray Maureen D Moore Rasa Zarnegar Thomas J FaheyⅢ | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 4 |
| 3 | Soybean hull as a dietary fiber source for dogs显示文摘 | Cole J T Fahey G C Merchen N R | 1999 | J Anim Sci1999，77，： | 1 |
| 4 | ln viw~ visualization of abdominal malignancies with acoustic radiation three elastograph显示文摘 | Fahey R J Nelson R C Bradway D P el al | 2008 | Phys MedBiol2008，53，1： | 1 |
| 5 | Selected fructooligosaccharide (l-kestose,nystose,and 1F-β-fructofuranosylnystose) composition of foods and feeds显示文摘 | CAMPBELL J M BAUER L L FAHEY G C | 1997 | Journal of Agricultural and Food Chemistry1997，45，8： | 1 |
| 6 | The effect of loop electrosurgical excision procedure on future pregnancy outcome显示文摘 | Samson S L Bentley I B Fahey T J | 2005 | Obstet Gynecol2005，105，2： | 1 |
| 7 | Effect of fibre source on short-chain fatty acid production and on the growth and toxin production by clostridium difficile显示文摘 | May T Mackie R I Fahey G C Cremin J C Garleb K A | 1994 | Gastroenterol1994，19，： | 1 |
| 8 | Soil freezing alters fine root dynamics in a northern hardwood forest 显示文摘 | Tierney G L Fahey T J Groffman P M | 2001 | Biogeochem- istry2001，56，2： | 1 |
| 9 | N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance显示文摘 | Yap SH Sheen CW Fahey J | 2007 | PLoS Med2007，4，12： | 1 |
| 10 | Fine root dynamics in a northern hardwood forest ecosystem, Hubbard Brook Experimental Forest, NH 显示文摘 | Fahey T J Hughes J W | 1994 | Journal of Ecology1994，82，3： | 1 |
| 11 | Effects of cal-cium salts of fatty acids and calcium salt of methio-nine hydroxy analogue on plasma prostaglandin F2ametabolite and milk fatty acid profiles in late lactationHolstein-Friesian cows 显示文摘 | FAHEY J MEE J F MURPHY J | 2002 | Theriogenology2002，58，8： | 1 |
| 12 | Effects of socioeconomic posi- tion and clinical risk factors on spontaneous and iatrogenic preterm birth 显示文摘 | Joseph KS Fahey J Shankardass K | 2014 | BMC2014，14，： | 1 |
| 13 | The Chemical Diversity and Distribution of Glucosinolates and Isothiocyanates among Plants 显示文摘 | Fahey J W Zalcmann A T Talalay P | 2002 | Phytochemistry2002，59，： | 1 |
| 14 | A conformational immunogen on VP-2 of infectious bursal disease virus that induces virus-neutralizing antibodies that passively protect chickens 显示文摘 | Fahey K J Erny K Crooks J | 1989 | J Gen Virol1989，70，6： | 1 |
| 15 | Deformation of granular materials due to rotation of principal axes显示文摘 | JOER H A LANIER J FAHEY M | 1998 | Geoteehnique1998，48，5： | 1 |
| 16 | Expression in Escherichia coli of cDNA fragments encoding the gene for the host protective antigen of infectious bursal disease virus显示文摘 | AZAD A A FAHEY K J BARRETT S A | 1986 | Virology1986，149，2： | 1 |
| 17 | Fine root turnover in a norlhern hantw(~x| fore~t:a direet comparison of the mdiooarbon and minirtfizotron methtxls 显示文摘 | TIERNEY G L FAHEY T J | 2002 | Canadian Journ'' d of Forest Research2002，32，： | 1 |
| 18 | The chemical diversity and distribution of glucosinolates and isothiocyanates among plants显示文摘 | Fahey J W Zalcmann A T Talalay P | 2001 | Phytochemistry2001，56，1： | 1 |
| 19 | An enteral formula containing fish oil, Iindigestible oligosaccharides, gum arabic and antioxidants affects plasma and colonic phospholipid fatty acid and prostaglandin profiles in pigs显示文摘 | Campbell J M Fahey G C Jr Lichtensteige | 1997 | J Nutr1997，127，1： | 1 |
| 20 | A eonformational immunogen on VP2 of infectious bursal disease virus that induce virus-neutralizing antibodies that passively protect chickens 显示文摘 | Fahey K J Erny K Crooks J | 1989 | J Gen Virol1989，70，： | 1 |
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