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| 1 | Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver显示文摘AIM: To determine whether Nigella sativa prevents hepatic ischemia-reperfusion injury to the liver. METHODS: Thirty rats were divided into three groups as sham (Group 1), control (Group 2), and Nigella sati-va (NS) treatment group (Group 3). All rats underwent hepatic ischemia for 45 min followed by 60 min period of reperfusion. Rats were intraperitoneally infused with only 0.9% saline solution in group 2. Rats in group 3 received NS (0.2 mL/kg) intraperitoneally, before isch-emia and before reperfusion. Blood samples and liver tissues were harvested from the rats, and then the rats were sacrifi ced. Serum aspartate aminotransfera-se (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels were determined. Total antioxidant capacity (TAC), catalase (CAT), total oxida-tive status (TOS), oxidative stress index (OSI) and my-eloperoxidase (MPO) in hepatic tissue were measured. Also liver tissue histopathology was evaluated by light microscopy. RESULTS: The levels of liver enzymes in group 3 weresignifi cantly lower than those in the group 2. TAC in liver tissue was significantly higher in group 3 than in group 2. TOS, OSI and MPO in hepatic tissue were signifi cantly lower in group 3 than the group 2. Histo-logical tissue damage was milder in the NS treatment group than that in the control group. CONCLUSION: Our results suggest that Nigella sa-tiva treatment protects the rat liver against to hepatic ischemia-reperfusion injury. | Fahrettin Yildiz Sacit Coban Alpaslan Terzi Mustafa Ates Nurten Aksoy Hale Cakir Ali Riza Ocak Muharrem Bitiren | 2008 | World Journal of Gastroenterology2008，14，33： | 8 |
| 2 | Role of insulin and insulin resistance in androgen excess disorders显示文摘Insulin has complex effects on cell growth,metabolism and differentiation,and these effects are mediated by a cell-surface bound receptor and eventually a cascade of intracellular signaling events.Among the several metabolic and growth-promoting effects of insulin,insulin resistance is defined as an attenuated effect of insulin on glucose metabolism,primarily the limited export of blood glucose into skeletal muscle and adipose tissue.On the other hand,not all the signaling pathways and insulin-responsive tissues are equally affected,and some effects other than the metabolic actions of insulin are overexpressed.Ovaries and the adrenal glands are two examples of tissues remaining sensitive to insulin actions where insulin may contribute to increased androgen secretion.Polycystic ovary syndrome(PCOS)is the most common form of androgen excess disorder(AED),and its pathogenesis is closely associated with insulin resistance.Patients with idiopathic hirsutism also exhibit insulin resistance,albeit lower than patients with PCOS.Although it is not as evident as in PCOS,patients with congenital adrenal hyperplasia may have insulin resistance,which may be further exacerbated with glucocorticoid overtreatment and obesity.Among patients with severe insulin resistance syndromes,irrespective of the type of disease,hyperinsulinemia promotes ovarian androgen synthesis independently of gonadotropins.It is highly debated in whom and how insulin resistance should be diagnosed and treated among patients with AEDs,including PCOS.It is not suitable to administer an insulin sensitizer relying on only some mathematical models used for estimating insulin resistance.Instead,the treatment decision should be based on the constellation of the signs,symptoms and presence of obesity;acanthosis nigricans;and some laboratory abnormalities such as impaired glucose tolerance and impaired fasting glucose. | Kursad Unluhizarci Zuleyha Karaca Fahrettin Kelestimur | 2021 | World Journal of Diabetes2021，12，5： | 5 |
| 3 | Closed-loop bulk air conditioning: A renewable energy-based system for deep mines in arctic regions显示文摘With depletion of shallow deposits,the number of underground mines expected to reach more than 3 km depth during their lifetime is growing.Although surface cooling plants are mostly effective in mine airconditioning,usually secondary cooling units are needed below 2 kmdepth.This need emerges due to the elevated thermal impacts caused by auto-compression of mine air as well as heat emissions from strata and mine machinery.As a result,in cold climates,like Canada,ultra-deep mines need their secondary underground cooling plants running year-round while the intake air must be heated to protect the sensitive machinery and liners from freezing during the winter season.To cool mine air,horizontal bulk-airconditioners with direct spray cooling systems are commonly used due to their high performance.Conventionally,sprayed water in bulk-air-coolers are mechanically circulated and refrigerated in coupled refrigeration plants.This set up can be transformed to a natural cooling/heating process by resurfacing the warm underground bulk-air-cooler spray water for mine air heating on the surface and re-sinking the chilled water for cooling in the underground bulk air coolers.This could significantly cut-down the fossil-fuel consumption in burners for mine air pre-conditioning and refrigeration cost when applicable.This paper presents an anonymous real-life example to study the feasibility of the proposed idea for an ultra-deep Canadian mine. | Ali Fahrettin Kuyuk Seyed Ali Ghoreishi-Madiseh Faramarz P.Hassani | 2020 | International Journal of Mining Science and Technology2020，30，4： | 3 |
| 4 | Comparison of intravitreal anti-vascular endothelial growth factor agents and treatment results in Irvine-Gass syndrome显示文摘AIM:To compare the efficacy of bevacizumab,ranibizumab,and aflibercept in pseudophakic cystoid macular edema(CME)patients with Irvine-Gass syndrome(IGS).METHODS:This study is designed as retrospective consecutive case series.Those who developed postoperative pseudophakic CME that refractory to topical treatment and were treated with anti-vascular endothelial growth factor(VEGF)agents included in the study.Optical coherence tomography(OCT)examination including central macular thickness(CMT),total macular volume(TMV),retinal nerve fiber layer(RNFL),ganglion cell layer(GCL)and choroidal thickness(ChT)measurements at the baseline,1 st,3 rd and 6 th month controls were performed.RESULTS:Fifty-nine eyes of 59 patients with CME and other healthy eyes of the patients(Control group)were evaluated.There were 22 eyes of 22 patients in the bevacizumab group(group 1),19 eyes of 19 patients in the ranibizumab group(group 2),and 18 eyes of 18 patients in the aflibercept group(group 3).There was no difference in terms of age,gender,axial length,IOP,and spherical equivalent values.The baseline subfoveal and mean ChT were higher in the IGS group.The difference between the baseline and sixth month values of subfoveal and mean ChT were compared in the CME groups,thinning was observed in all three groups.GCL was thinner in the patient group at the 6 th month of treatment.The resolution time of CME was observed faster in group 1.CONCLUSION:All three anti-VEGF agents seem to be effective in CME but bevacizumab appears to be slightly more cost-effective than the other two alternatives. | Fahrettin Akay Mehmed Ugur Isιk Berkay Akmaz Yusuf Ziya Güven | 2020 | International Journal of Ophthalmology(English edition)2020，13，10： | 2 |
| 5 | Resection and primary anastomosis with or without modified blow-hole colostomy for sigmoid volvulus显示文摘AIM: To evaluate the efficacy of resection and primary anastomosis (RPA) and RPA with modified blow-hole colostomy for sigmoid volvulus. METHODS: From March 2000 to September 2007, 77 patients with acute sigmoid volvulus were treated. A total of 47 patients underwent RPA or RPA with modified blow-hole colostomy. Twenty-five patients received RPA (Group A), and the remaining 22 patients had RPA with modified blow-hole colostomy (Group B). The clinical course and postoperative complications of the two groups were compared. RESULTS: The mean hospital stay, wound infection and mortality did not differ significantly between the groups. Superficial wound infection rate was higher in group A (32% vs 9.1%). Anastomotic leakage was observed only in group A, with a rate of 6.3%. The difference was numerically impressive but was statistically not significant. CONCLUSION: RPA with modified blow-hole colostomy provides satisfactory results. It is easy to perform and may become a method of choice in patients with sigmoid volvulus. Further studies are required to further establish its role in the treatment of sigmoid volvulus. | Sacid Coban Mehmet Yilmaz Alpaslan Terzi Fahrettin Yildiz Dincer Ozgor Cengiz Ara Saim Yologlu Vedat Kirimlioglu | 2008 | World Journal of Gastroenterology2008，14，36： | 2 |
| 6 | Alcoholism-related alterations in spectrum,coherence,and phase synchrony of topical electroencephalogram显示文摘 | Gleb V Tcheslavski Fahrettin F Gonen | 2012 | Computers in Biology and Medicine2012，42，4： | 1 |
| 7 | Sheehan’s Syndrome显示文摘 | Fahrettin Kele?timur | 2003 | Pituitary2003，，4： | 1 |
| 8 | Effect of temperature and pH onnonenzymic browning in minced dried pepper during storage显示文摘 | Fahrettin G Sami E | 1998 | Journal of Engineering and Environmental Science1998，，： | 1 |
| 9 | 显示文摘 | Serkan T Fahrettin O Ilyas K | 2008 | Journal of Materials Processing Technology2008，207，： | 1 |
| 10 | ZnO/p-Si Heterojunction Photodiode by Sol-Gel Deposition of Nanostructure n-ZnO Film on p-Si Substrate显示文摘 | Fahrettin Yakuphanoglu Yasemin Caglar Mujdat Caglar | 2010 | Materials Science in Semiconductor Processing2010，13，3： | 1 |
| 11 | Com-parison of dexmedetomidine and midazolam for monitored anesthesiacare combined with tramadol via patient-controlled analgesia in endo-scopic nasal surgery:A prospective,randomized,double-blind,clini-cal study显示文摘 | Karaaslan KY Fahrettin Gulcu NC Cemil Sereflican MK | 2007 | Current therapeutic research2007，68，2： | 1 |
| 12 | Analy si s of forming limit susing ductile fract ure crit eria显示文摘 | Ozt urk Fahrettin L ee Daeyong | 2004 | Journal of Materials Processing Technology2004，147，3： | 1 |
| 13 | Relation of microvessel density with microvascular invasion, metastasis and progno- sis in renal cell carcinoma 显示文摘 | Esin Y Semih A Fahrettin G | 2008 | BJU International2008，101，6： | 1 |
| 14 | Analysis of sarcoplasmic proteins in natural populations of mountain trout with SDS-PAGE显示文摘 | Orhan Demir Ali Günlü Fahrettin Kücük | 2011 | African Journal of Biotechnology2011，10，11： | 1 |
| 15 | Non-enzymic browning reactions in boiled juiceand it s mod-els during storage 显示文摘 | Huseyin Bozkurt Fahrettin Gogus SamiEren | 1999 | Food Chemist ry1999，，64： | 1 |
| 16 | The Effect of Fluorine on the Structural,Surface Morphology and Optical Properties of Zn O Thin Films显示文摘 | Fahrettin Yakuphanoglu Yasemin Caglar Saliha Ilican | 2007 | Physica B2007，394，1： | 1 |
| 17 | A new methodology for ductile fracture criteria to predict the forming limits 显示文摘 | Fahrettin Ozturk Daeyong Lee | 2007 | Journal of Materials Engineering and Performance2007，16，2： | 1 |
| 18 | Silicosis in manufacture of electric cable: Report of four eases显示文摘 | FAHRETTIN T KAMIL G SAFIYE G | 2007 | J Occud Health2007，49，： | 1 |
| 19 | Invasive Carassius carp in Georgia: Current state of knowledge and future perspectives显示文摘 | Bella JAPOSHVILI Levan MUMLADZE Fahrettin KUCUK | 2013 | Current Zoology2013，59，6： | 1 |
| 20 | Structural characterization and antimicrobial activity of 1,3-bis(2-benzimidazyl)-2-thiapropane ligand and its Pd(II) and Zn(II) halide complexes显示文摘 | Naz M. Agh-Atabay Basaran Dulger Fahrettin Gucin | 2005 | European Journal of Medicinal Chemistry2005，，11： | 1 |
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