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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells显示文摘 | De Falco E Porcelli D Torella AR Straino S Iachininoto MG Orlandi A | 2004 | Blood2004，104，12： | 1 |
| 3 | Genetic divergence of a sym-patric lake-resident-anadromous three-spined stickleback Gasterosteusaculeatus species pair显示文摘 | Drevecky C J Falco R Aguirre W E | 2013 | Journal of Fish Biology2013，83，1： | 1 |
| 4 | Simple method for low colorectal anastomosis with the double stapling technique显示文摘 | Falco E Celoria G Nardini A | 1995 | Br J Surg1995，82，： | 1 |
| 5 | Severe nucleoside-associated lac tic acidosis in human immunodeficiency virus infected patients:report of 12 cases and review of the literature 显示文摘 | Falco V Rodriguez D Ribera E | 2002 | Clin Infect Dis2002，34，6： | 1 |
| 6 | Lipoprotein(a) in young individuals as a marker of the presence of ischemich eart disease and the severity of coronary lesions显示文摘 | Zorio E Falco C Arnau M A | 2006 | Haemato logica2006，91，4： | 1 |
| 7 | SDF-1 involvement in endothelial phenotype and ischemia induced recruitment of bone marrow progenitor cells显示文摘 | De Falco E Porcelli D Torella AR | 2004 | Blood2004，104，12： | 1 |
| 8 | Biological role and potential therapeutic targeting of the chemokine receptor CXCR4 in undifferentiated thyroid cancer 显示文摘 | De Falco V Guarino V Avilla E | 2007 | Cancer Res2007，67，11： | 1 |
| 9 | Echinococcus granulosus-specific T-cell lines derived from patients at various clinical stages of cystic echinococcosis显示文摘 | Rigano R Buttari B De Falco E | 2004 | Parasit Immunol2004，26，： | 1 |
| 10 | Fa- cing classification problems with particle swarm optimi- zation 显示文摘 | De FALCO I Della CIOPPA A TARANTINO E | 2007 | Applied Soft Computing2007，7，3： | 1 |
| 11 | Facing classification problems with particle swarm optimization 显示文摘 | FALCO D CIOPPA A D TARANTINO E | 2007 | Applied Soft Computing2007，，7： | 1 |
| 12 | SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells 显示文摘 | De Falco E Porcelli D Torella AR | 2004 | Blood2004，104，12： | 1 |
| 13 | Early expression of triggering receptors and regulatory role of 2B4 in human nat ural killer cell precursors undergoing in vitro differentiation显示文摘 | Sivori S Falco M Marcenaro E | 2002 | ProcNatlAcadSciUSA2002，99，： | 1 |
| 14 | Facing classification problems with Particle Swarm Optimization 显示文摘 | I De Falco A Della Cioppa E Tarantino | 2007 | Applied Sott Computing (S1568-4946)2007，7，3： | 1 |
| 15 | SDF-1 involvement in endot-helial phenotype and ischemia-induced recruitment of bone marrow p-rogenitor cells显示文摘 | De Falco E Porcelli D Torella AR | 2004 | Blood2004，104，： | 1 |
| 16 | Severe nucleoside-associated lactic acidosis in human immunodeficiency virus-infected patients :report of 12 cases and review of literature显示文摘 | Falco V Rodriguez D Ribera E | 2002 | Clin infect Dis2002，34，6： | 1 |
| 17 | SDF-1 involvement in endothelial phenotype and isehemia-induced recruitment of bone marrow progenitor cells 显示文摘 | De Falco E Poreelli D Torella AR | 2004 | Blood2004，104，12： | 1 |
| 18 | SDF-1 involve- ment in endothelial phenotype and ischemia-induced recruit- ment of bone marrow progenitor cells显示文摘 | Falco E D Poreelli D Torella A R | 2004 | Blood2004，104，2： | 1 |
| 19 | SDF-1 involvement in endothelial pheno type and ischemia-induced recruitment of bone marrow progenitor cells 显示文摘 | De Falco E Porcelli D Torella AR | 2004 | Blood2004，104，12： | 1 |
| 20 | SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells显示文摘 | De Falco E Porcelli D Torella AR | 2004 | Blood2004，104，： | 1 |
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