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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Structural evolution of mechanically alloyed nanocrystalline Fe-28Al powders显示文摘 | FAN R H SUN J T GONG H Y SUN K N WANG W M | 2005 | Powder Technol2005，149，： | 1 |
| 3 | Novel MMC Microstructure with Tailored Distribution of the Reinforcing Phase 显示文摘 | Peng H X Fan Z Evans J R G | 2001 | Journal of Microscopy2001，201，： | 1 |
| 4 | Ionic Liquid-assisted Extraction of Paeonol from Cynanchum Paniculatum显示文摘 | JIN R H FAN L AN X N | 2011 | Chromatographia2011，73，78： | 1 |
| 5 | MODIS enhanced vegetation index predicts tree species richness across forested ecoregions in the contiguous USA显示文摘 | Waring R H Coops N C Fan W | 2006 | Remote Sensing of Environment2006，103，2： | 1 |
| 6 | Decreased expression of miR- 126 correlates with metastatic recurrence of hepatocellular carcinoma显示文摘 | Chen H Miao R Fan J | 2013 | Clin Exp Metastas2013，30，5： | 1 |
| 7 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 8 | Giardia Lamblia,Hapoid genome size determined by pulsed field gel electrophoresis is less than 12Mb显示文摘 | Fan J B S H Korman C R Canter | 1991 | Nucleic Acids Res1991，19，： | 1 |
| 9 | Working set selection using the second order information for training SVM显示文摘 | Fan R E Chen P H Lin C J | 2005 | Journal of Machine Learning Research2005，，6： | 1 |
| 10 | Absorption of dilute SO2 gas stream with conversion to polymeric ferric sulfate for use in water treatment显示文摘 | Butler A D Fan M H Brown R C | | 0，，： | 1 |
| 11 | Finite element meth- od and constitutive modelling and computation for un- saturated soils 显示文摘 | Li X K Thomas H R Fan Y Q | 1999 | Computer Methods in Applied Mechanics and Engineering1999，169，1： | 1 |
| 12 | Numerical simulation of effects of activating flux on flow patterns and weld penetration in ATIG welding显示文摘 | Zhang R H Fan D | 2007 | Science and Technology of Welding and Joining2007，12，1： | 1 |
| 13 | A hydrogen peroxide biosensor based on the bioelectrocatalysis of hemoglobin incorporated in a kieselgubr film 显示文摘 | WANG H GUAN R FAN C | 2002 | Sensors and Actuators B2002，84，23： | 1 |
| 14 | Genetic diversity and disease control in rice显示文摘 | Zhu Y Y Chen H R Fan J H | 2000 | Nature2000，406，6797： | 1 |
| 15 | Aberrantly glycosylated IgA1in IgA nephropathy patients is recognized by IgG antibodies withrestricted heterogeneity显示文摘 | Suzuki H Fan R Zhang Z | 2009 | J Clin Invest2009，119，6： | 1 |
| 16 | Caspase family proteases and apoptosis显示文摘 | Fan T J Han L H Cong R S | 2005 | Acta Biochim Biophys Sin2005，37，11： | 1 |
| 17 | Effect of substrate temperature on the room-temperature ferromagnetism of Cu-doped ZnO films显示文摘 | FAN Y R MASAKI T YASUHIKO H | 2009 | J Cryst Growth2009，311，： | 1 |
| 18 | Hermaphroditic liquid-crystal microlens显示文摘 | REN H W WU J R FAN Y H | 2005 | Optics Letters2005，30，4： | 1 |
| 19 | Multi-laboratory validation of a standard method for quantifying proanthocyanidins in cranberry powders显示文摘 | Prior R L Fan E Ji H P Howell A Nio C Payne M J Reed J | 2010 | Journal of the Science of Food and Agriculture2010，90，9： | 1 |
| 20 | Effect and mechanism of Intermedin1-35 on two-kidney one-clip hypertensive rats显示文摘 | Liang Y Xue L H Fan J R | 2011 | Chin Pharmacol Bull2011，27，1： | 1 |
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